The power of genetic diversity in genome-wide association studies of lipids


Por: Graham, SE, Clarke, SL, Wu, KHH, Kanoni, S, Zajac, GJM, Ramdas, S, Surakka, I, Ntalla, I, Vedantam, S, Winkler, TW, Locke, AE, Marouli, E, Hwang, MY, Han, S, Narita, A, Choudhury, A, Bentley, AR, Ekoru, K, Verma, A, Trivedi, B, Martin, HC, Hunt, KA, Hui, Q, Klarin, D, Zhu, X, Thorleifsson, G, Helgadottir, A, Gudbjartsson, DF, Holm, H, Olafsson, I, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, B, Rasheed, H, Ruotsalainen, SE, Havulinna, AS, Veturi, Y, Feng, QP, Rosenthal, EA, Lingren, T, Pacheco, JA, Pendergrass, SA, Haessler, J, Giulianini, F, Bradford, Y, Miller, JE, Campbell, A, Lin, K, Millwood, IY, Hindy, G, Rasheed, A, Faul, JD, Zhao, W, Weir, DR, Turman, C, Huang, HY, Graff, M, Mahajan, A, Brown, MR, Zhang, WH, Yu, KT, Schmidt, EM, Pandit, A, Gustafsson, S, Yin, XY, Luan, JA, Zhao, JH, Matsuda, F, Jang, HM, Yoon, K, Medina-Gomez, C, Pitsillides, A, Hottenga, JJ, Willemsen, G, Wood, AR, Ji, YJ, Gao, ZS, Haworth, S, Mitchell, RE, Chai, JF, Aadahl, M, Yao, J, Manichaikul, A, Warren, HR, Ramirez, J, Bork-Jensen, J, Karhus, LL, Goel, A, Sabater-Lleal, M, Noordam, R, Sidore, C, Fiorillo, E, McDaid, AF, Marques-Vidal, P, Wielscher, M, Trompet, S, Sattar, N, Mollehave, LT, Thuesen, BH, Munz, M, Zeng, LY, Huang, JF, Yang, B, Poveda, A, Kurbasic, A, Lamina, C, Forer, L, Scholz, M, Galesloot, TE, Bradfield, JP, Daw, EW, Zmuda, JM, Mitchell, JS, Fuchsberger, C, Christensen, H, Brody, JA, Feitosa, MF, Wojczynski, MK, Preuss, M, Mangino, M, Christofidou, P, Verweij, N, Benjamins, JW, Engmann, J, Kember, RL, Slieker, RC, Lo, KS, Zilhao, NR, Le, P, Kleber, ME, Delgado, GE, Huo, S, Ikeda, DD, Iha, H, Yang, J, Liu, J, Leonard, HL, Marten, J, Schmidt, B, Arendt, M, Smyth, LJ, Canadas-Garre, M, Wang, CL, Nakatochi, M, Wong, A, Hutri-Kahonen, N, Sim, XL, Xia, R, Huerta-Chagoya, A, Fernandez-Lopez, JC, Lyssenko, V, Ahmed, M, Jackson, AU, Irvin, MR, Oldmeadow, C, Kim, HN, Ryu, S, Timmers, PRHJ, Arbeeva, L, Dorajoo, R, Lange, LA, Chai, XR, Prasad, G, Lores-Motta, L, Pauper, M, Long, JR, Li, XH, Theusch, E, Takeuchi, F, Spracklen, CN, Loukola, A, Bollepalli, S, Warner, SC, Wang, YX, Wei, WB, Nutile, T, Ruggiero, D, Sung, YJ, Hung, YJ, Chen, SF, Liu, FC, Yang, JY, Kentistou, KA, Gorski, M, Brumat, M, Meidtner, K, Bielak, LF, Smith, JA, Hebbar, P, Farmaki, AE, Hofer, E, Lin, MX, Xue, C, Zhang, JF, Concas, MP, Vaccargiu, S, van der Most, PJ, Pitkanen, N, Cade, BE, Lee, J, van der Laan, SW, Chitrala, KN, Weiss, S, Zimmermann, ME, Lee, JY, Choi, HS, Nethander, M, Freitag-Wolf, S, Southam, L, Rayner, NW, Wang, CA, Lin, SY, Wang, JS, Couture, C, Lyytikainen, LP, Nikus, K, Cuellar-Partida, G, Vestergaard, H, Hildalgo, B, Giannakopoulou, O, Cai, QY, Obura, MO, van Setten, J, Li, XY, Schwander, K, Terzikhan, N, Shin, JH, Jackson, RD, Reiner, AP, Martin, LW, Chen, ZM, Li, LM, Highland, HM, Young, KL, Kawaguchi, T, Thiery, J, Bis, JC, Nadkarni, GN, Launer, LJ, Li, HX, Nalls, MA, Raitakari, OT, Ichihara, S, Wild, SH, Nelson, CP, Campbell, H, Jager, S, Nabika, T, Al-Mulla, F, Niinikoski, H, Braund, PS, Kolcic, I, Kovacs, P, Giardoglou, T, Katsuya, T, Bhatti, F, de Kleijn, D, de Borst, GJ, Kim, EK, Adams, HHH, Ikram, MA, Zhu, XF, Asselbergs, FW, Kraaijeveld, AO, Beulens, JWJ, Shu, XO, Rallidis, LS, Pedersen, O, Hansen, T, Mitchell, P, Hewitt, AW, Kahonen, M, Perusse, L, Bouchard, C, Tonjes, A, Chen, YDI, Pennell, CE, Mori, TA, Lieb, W, Franke, A, Ohlsson, C, Mellstrom, D, Cho, YS, Lee, H, Yuan, JM, Koh, WP, Rhee, SY, Woo, JT, Heid, IM, Stark, KJ, Volzke, H, Homuth, G, Evans, MK, Zonderman, AB, Polasek, O, Pasterkamp, G, Hoefer, IE, Redline, S, Pahkala, K, Oldehinkel, AJ, Snieder, H, Biino, G, Schmidt, R, Schmidt, H, Chen, YE, Bandinelli, S, Dedoussis, G, Thanaraj, TA, Kardia, SLR, Kato, N, Schulze, MB, Girotto, G, Jung, B, Boger, CA, Joshi, PK, Bennett, DA, De Jager, PL, Lu, XF, Mamakou, V, Brown, M, Caulfield, MJ, Munroe, PB, Guo, XQ, Ciullo, M, Jonas, JB, Samani, NJ, Kaprio, J, Pajukanta, P, Adair, LS, Bechayda, SA, de Silva, HJ, Wickremasinghe, AR, Krauss, RM, Wu, JY, Zheng, W, den Hollander, AI, Bharadwaj, D, Correa, A, Wilson, JG, Lind, L, Heng, CK, Nelson, AE, Golightly, YM, Wilson, JF, Penninx, B, Kim, HL, Attia, J, Scott, RJ, Rao, DC, Arnett, DK, Walker, M, Koistinen, HA, Chandak, GR, Yajnik, CS, Mercader, JM, Tusie-Luna, T, Aguilar-Salinas, CA, Villalpando, CG, Orozco, L, Fornage, M, Tai, ES, van Dam, RM, Lehtimaki, T, Chaturvedi, N, Yokota, M, Liu, J, Reilly, DF, McKnight, AJ, Kee, F, Jockel, KH, McCarthy, MI, Palmer, CNA, Vitart, V, Hayward, C, Simonsick, E, van Duijn, CM, Lu, F, Qu, J, Hishigaki, H, Lin, X, Marz, W, Parra, EJ, Cruz, M, Gudnason, V, Tardif, JC, Lettre, G, 't Hart, LM, Elders, PJM, Damrauer, SM, Kumari, M, Kivimaki, M, van der Harst, P, Spector, TD, Loos, RJF, Province, MA, Psaty, BM, Brandslund, I, Pramstaller, PP, Christensen, K, Ripatti, S, Widen, E, Hakonarson, H, Grant, SFA, Kiemeney, LALM, de Graaf, J, Loeffler, M, Kronenberg, F, Gu, DF, Erdmann, J, Schunkert, H, Franks, PW, Linneberg, A, Jukema, JW, Khera, AV, Mannikko, M, Jarvelin, MR, Kutalik, Z, Cucca, F, Mook-Kanamori, DO, van Dijk, KW, Watkins, H, Strachan, DP, Grarup, N, Sever, P, Poulter, N, Rotter, JI, Dantoft, TM, Karpe, F, Neville, MJ, Timpson, NJ, Cheng, CY, Wong, TY, Khor, CC, Sabanayagam, C, Peters, A, Gieger, C, Hattersley, AT, Pedersen, NL, Magnusson, PKE, Boomsma, DI, de Geus, EJC, Cupples, LA, van Meurs, JBJ, Ghanbari, M, Rsen, PGL, Huang, W, Kim, YJ, Tabara, Y, Wareham, NJ, Langenberg, C, Zeggini, E, Kuusisto, J, Laakso, M, Ingelsson, E, Abecasis, G, Chambers, JC, Kooner, JS, de Vries, PS, Morrison, AC, North, KE, Daviglus, M, Kraft, P, Martin, NG, Whitfield, JB, Abbas, S, Saleheen, D, Walters, RG, Holmes, MV, Black, C, Smith, BH, Justice, AE, Baras, A, Buring, JE, Ridker, PM, Chasman, DI, Kooperberg, C, Wei, WQ, Jarvik, GP, Namjou, B, Hayes, MG, Ritchie, MD, Jousilahti, P, Salomaa, V, Hveem, K, Asvold, BO, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Thorsteinsdottir, U, Stefansson, K, Ho, YL, Lynch, JA, Rader, DJ, Tsao, PS, Chang, KM, Cho, K, O'Donnell, CJ, Gaziano, JM, Wilson, P, Rotimi, CN, Hazelhurst, S, Ramsay, M, Trembath, RC, van Heel, DA, Tamiya, G, Yamamoto, M, Kim, BJ, Mohlke, KL, Frayling, TM, Hirschhorn, JN, Kathiresan, S, Boehnke, M, Natarajan, P, Peloso, GM, Brown, CD, Morris, AP, Assimes, TL, Deloukas, P, Sun, YV, Willer, CJ

Publicada: 23 dic 2021 Ahead of Print: 1 dic 2021
Resumen:
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use(1). Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels(2), heart disease remains the leading cause of death worldwide(3). Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS(4-23) have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele frequencies, effect sizes and linkage-disequilibrium patterns(24). Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes. We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). Modest gains in the number of discovered loci and ancestry-specific variants were also achieved. As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine(25), we anticipate that increased diversity of participants will lead to more accurate and equitable(26) application of polygenic scores in clinical practice.

Filiaciones:
Graham, SE:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA

Clarke, SL:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

 Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

Wu, KHH:
 Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

Kanoni, S:
 Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

Zajac, GJM:
 Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

 Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Ramdas, S:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

Surakka, I:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA

Ntalla, I:
 Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Clin Pharmacol, London, England

Vedantam, S:
 Boston Childrens Hosp, Endocrinol, Boston, MA USA

 Broad Inst, Med & Populat Genet, Cambridge, MA USA

Winkler, TW:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany

Locke, AE:
 Washington Univ, McDonnell Genome Inst, St Louis, MO 63110 USA

 Washington Univ, Dept Med, St Louis, MO USA

Marouli, E:
 Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

Hwang, MY:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea

Han, S:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea

Narita, A:
 Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi, Japan

Choudhury, A:
 Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa

Bentley, AR:
 NHGRI, Ctr Res Genom & GLobal Hearth, NIH, Bethesda, MD 20892 USA

Ekoru, K:
 NHGRI, Ctr Res Genom & GLobal Hearth, NIH, Bethesda, MD 20892 USA

Verma, A:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

Trivedi, B:
 Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England

Martin, HC:
 Wellcome Sanger Inst, Hinxton, England

Hunt, KA:
 Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England

Hui, Q:
 Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

 Atlanta VA Hlth Care Syst, Decatur, GA USA

Klarin, D:
 Malcolm Randall VA Med Ctr, Gainesville, FL USA

 Univ Florida, Coll Med, Div Vasc Surg & Endovasc Therapy, Gainesville, FL USA

 Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA

Zhu, X:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

 Penn State Univ, Dept Stat, University Pk, PA 16802 USA

 Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA

 Stanford Univ, Dept Stat, Stanford, CA 94305 USA

 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

Thorleifsson, G:
 Amgen Inc, deCODE Genet, Reykjavik, Iceland

Helgadottir, A:
 Amgen Inc, deCODE Genet, Reykjavik, Iceland

Gudbjartsson, DF:
 Amgen Inc, deCODE Genet, Reykjavik, Iceland

 Univ Iceland, Sch Engn & Nat Sci, Reykjavik, Iceland

Holm, H:
 Amgen Inc, deCODE Genet, Reykjavik, Iceland

Olafsson, I:
 Natl Univ Hosp Iceland, Dept Clin Biochem, Landspitali, Reykjavik, Iceland

Akiyama, M:
 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

 Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan

Sakaue, S:
 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

 Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan

 Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan

Terao, C:
 RIKEN, Lab Stat & Translat Genet, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

Kanai, M:
 Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA

 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

 Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA

Zhou, W:
 Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

 Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA

 Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA

Brumpton, B:
 Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway

 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England

 Trondheim Reg & Univ Hosp, Dept Thorac Med, St Olavs Hosp, Trondheim, Norway

Rasheed, H:
 Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway

 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England

Ruotsalainen, SE:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland

Havulinna, AS:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland

 Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

Veturi, Y:
 Univ Penn, Inst Biomed Informat, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA

Feng, QP:
 Vanderbilt Univ Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN USA

Rosenthal, EA:
 Univ Washington, Dept Med Med Genet, Seattle, WA 98195 USA

Lingren, T:
 Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA

Pacheco, JA:
 Northwestern Univ, Ctr Genet Med, Evanston, IL USA

Pendergrass, SA:
 Genentech Inc, San Francisco, CA 94080 USA

Haessler, J:
 Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

Giulianini, F:
 Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA

Bradford, Y:
 Univ Penn, Inst Biomed Informat, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA

Miller, JE:
 Univ Penn, Inst Biomed Informat, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA

Campbell, A:
 Univ Edinburgh, Western Gen Hosp, Ctr Genom & Expt Med, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland

 Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland

Lin, K:
 Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

 Univ Oxford, Nuffield Dept Populat Hearth, Epidemiol Studies Unit, Oxford, England

Millwood, IY:
 Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

 Univ Oxford, Nuffield Dept Populat Hearth, Epidemiol Studies Unit, Oxford, England

 Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford, England

Hindy, G:
 Qatar Univ, Dept Populat Med, QU Hlth, Coll Med, Doha, Qatar

Rasheed, A:
 Ctr Noncommunicable Dis, Karachi, Pakistan

Faul, JD:
 Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA

Zhao, W:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Weir, DR:
 Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA

Turman, C:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA USA

Huang, HY:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA USA

Graff, M:
 Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

Mahajan, A:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford, England

Brown, MR:
 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Dept Epidemiol, Sch Publ Hlth, Houston, TX 77030 USA

Zhang, WH:
 Imperial Coll London, Dept Epidemiol & Biostat, London, England

 London North West Univ Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Southall, Middx, England

 Imperial Coll Healthcare NHS Trust, London, England

Yu, KT:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Schmidt, EM:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Pandit, A:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Gustafsson, S:
 Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden

Yin, XY:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Luan, JA:
 Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England

Zhao, JH:
 Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Strangeways Res Lab, Cambridge, England

Matsuda, F:
 Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan

Jang, HM:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea

Yoon, K:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea

Medina-Gomez, C:
 Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands

 Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

Pitsillides, A:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

Hottenga, JJ:
 Vrije Univ Amsterdam, Dept Biol Psychol Behav & Movement Sci, Amsterdam, Netherlands

 VU Med Ctr Amsterdam, Amsterdam Publ Hlth, Amsterdam, Netherlands

Willemsen, G:
 Vrije Univ Amsterdam, Dept Biol Psychol Behav & Movement Sci, Amsterdam, Netherlands

 VU Med Ctr Amsterdam, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

Wood, AR:
 Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter, Devon, England

Ji, YJ:
 Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter, Devon, England

Gao, ZS:
 Nanjing Univ Chinese Med, Dept Clin Acupuncture & Moxibust, Nanjing, Peoples R China

 Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

 Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

Haworth, S:
 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England

 Univ Bristol, Bristol Dent Sch, Bristol, Avon, England

Mitchell, RE:
 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England

 Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England

Chai, JF:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

 Natl Univ Hlth Syst, Singapore, Singapore

Aadahl, M:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

Yao, J:
 Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, LABioMed, Inst Translat Genom & Populat Sci,Dept Pediat, Torrance, CA 90509 USA

Manichaikul, A:
 Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA

Warren, HR:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London, England

Ramirez, J:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

Bork-Jensen, J:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

Karhus, LL:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

Goel, A:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford, England

 Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England

Sabater-Lleal, M:
 Hosp Santa Creu & St Pau IIB St Pau, Grp Genom Complex Dis, Res Inst, Barcelona, Spain

 Karolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Med,Cardiovasc Med Unit, Stockholm, Sweden

Noordam, R:
 Leiden Univ Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands

Sidore, C:
 Italian Natl Council Res IRGB CNR, Inst Genet & Biomed Res, Cagliari, Italy

Fiorillo, E:
 Italian Natl Council Res IRGB CNR, Inst Genet & Biomed Res, Lanusei, Italy

McDaid, AF:
 Univ Lausanne, Univ Ctr Primary Care & Publ Hlth, Lausanne, Switzerland

 Swiss Inst Bioinformat, Lausanne, Switzerland

Marques-Vidal, P:
 Lausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland

 Univ Lausanne, Lausanne, Switzerland

Wielscher, M:
 Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

Trompet, S:
 Leiden Univ Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands

 Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands

Sattar, N:
 BHF Glasgow Cardiovasc Res Ctr, Fac Med, Glasgow, Lanark, Scotland

Mollehave, LT:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

Thuesen, BH:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

Munz, M:
 Univ Lubeck, Univ Heart Ctr Lubeck, DZHK German Res Ctr Cardiovasc Res, Inst Cardiogenet,Partner Site Hamburg Lubeck Kiel, Lubeck, Germany

 Charite Univ Med Berlin, Berlin, Germany

 Free Univ Berlin, Berlin, Germany

 Humboldt Univ, Berlin, Germany

 Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany

 Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany

Zeng, LY:
 Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany

 Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany

 Deutsch Zentrum Herz Kreislauf Forsch DZHK, Partner Site Munich Heart Alliance, Munich, Germany

Huang, JF:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis,Dept Epidemiol, Beijing, Peoples R China

Yang, B:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis,Dept Epidemiol, Beijing, Peoples R China

Poveda, A:
 Lund Univ, Diabet Ctr, Malmo, Sweden

Kurbasic, A:
 Lund Univ, Diabet Ctr, Malmo, Sweden

Lamina, C:
 Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria

 German Chron Kidney Dis Study, Innsbruck, Austria

Forer, L:
 Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria

 German Chron Kidney Dis Study, Innsbruck, Austria

Scholz, M:
 Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany

 Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany

Galesloot, TE:
 Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands

Bradfield, JP:
 Quantinuum Res, Wayne, PA USA

Daw, EW:
 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA

Zmuda, JM:
 Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA

Mitchell, JS:
 Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, Bolzano, Italy

Fuchsberger, C:
 Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, Bolzano, Italy

Christensen, H:
 Lillebaelt Hosp, Dept Clin Biochem, Vejle, Denmark

Brody, JA:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

Feitosa, MF:
 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA

Wojczynski, MK:
 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA

Preuss, M:
 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

Mangino, M:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

 Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London, England

Christofidou, P:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

Verweij, N:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

Benjamins, JW:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

Engmann, J:
 UCL, Inst Cardiovasc Sci, London, England

 UCL, Dept Epidemiol & Publ Hlth, London, England

Kember, RL:
 Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

Slieker, RC:
 Amsterdam UMC, Dept Epidemiol & Biostat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

 Leiden Univ Med Ctr, Dept Cell & Chem Biol, Leiden, Netherlands

Lo, KS:
 Montreal Heart Inst, Montreal, PQ, Canada

Zilhao, NR:
 Iceland Heart Assoc, Reykjavik, Iceland

Le, P:
 Univ Toronto Mississauga, Dept Anthropol, Mississauga, ON, Canada

Kleber, ME:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany

 Synlab MVZ Humangenet Mannheim, Mannheim, Germany

Delgado, GE:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany

Huo, S:
 Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China

Ikeda, DD:
 Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Biomed Technol Res Ctr, Tokushima, Japan

Iha, H:
 Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Biomed Technol Res Ctr, Tokushima, Japan

Yang, J:
 Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

 Wenzhou Med Univ, Inst Adv Res, Wenzhou, Peoples R China

 Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA

 Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL USA

Liu, J:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

Leonard, HL:
 NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA

 Data Tecn Int, Glen Echo, MD USA

Marten, J:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

Schmidt, B:
 Univ Duisburg Essen, Inst Med Informat Biometrie & Epidemiol, Essen, Germany

Arendt, M:
 Univ Duisburg Essen, Inst Med Informat Biometrie & Epidemiol, Essen, Germany

 Univ Appl Sci & Arts Dortmund, Dept Comp Sci, Dortmund, Germany

Smyth, LJ:
 Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

Canadas-Garre, M:
 Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

Wang, CL:
 Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China

 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

Nakatochi, M:
 Nagoya Univ, Dept Integrated Hlth Sci, Publ Hlth Informat Unit, Grad Sch Med, Nagoya, Aichi, Japan

Wong, A:
 UCL, MRC Unit Lifelong Hlth & Ageing, London, England

Hutri-Kahonen, N:
 Tampere Univ Hosp, Dept Pediat, Tampere, Finland

 Tampere Univ, Fac Med & Hlth Technol, Dept Pediat, Tampere, Finland

Sim, XL:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

 Natl Univ Hlth Syst, Singapore, Singapore

Xia, R:
 Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Brown Fdn Inst Mol Med, Houston, TX 77030 USA

Huerta-Chagoya, A:
 UNAM, Dept Med Genom & Toxicol Ambiental, Inst Invest Biomed, Ciudad De Mexico, Mexico

Fernandez-Lopez, JC:
 Inst Nacl Med Genom, Dept Genom Computac, Ciudad De Mexico, Mexico

Lyssenko, V:
 Lund Univ, Diabet Ctr, Malmo, Sweden

 Univ Bergen, Ctr Diabet Res, Bergen, Norway

Ahmed, M:
 CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad, India

Jackson, AU:
 Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

 Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Irvin, MR:
 Univ Alabama Birmingham, Sch Publ Hlth, Epidemiol, Birmingham, AL 35294 USA

Oldmeadow, C:
 Hunter Med Res Inst, Newcastle, NSW, Australia

Kim, HN:
 Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul, South Korea

 Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea

Ryu, S:
 Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul, South Korea

 Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul, South Korea

Timmers, PRHJ:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Edinburgh, Midlothian, Scotland

Arbeeva, L:
 Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA

Dorajoo, R:
 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

Lange, LA:
 Univ Colorado, Dept Med, Div Biomed Informat & Personalized Med, Anschutz Med Campus, Aurora, CO USA

Chai, XR:
 Natl Univ Hlth Syst, Singapore, Singapore

 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Ocular Epidemiol, Singapore, Singapore

 Natl Univ Singapore, Dept Ophthalmol, Singapore, Singapore

Prasad, G:
 CSIR, Genom & Mol Med Unit, Inst Genom & Integrat Biol, New Delhi, India

 Acad Sci & Innovat Res, CSIR Inst Genom & Integrat Biol Campus, New Delhi, India

Lores-Motta, L:
 Radboud Univ Nijmegen, Dept Ophthalmol, Med Ctr, Nijmegen, Netherlands

Pauper, M:
 Radboud Univ Nijmegen, Dept Ophthalmol, Med Ctr, Nijmegen, Netherlands

Long, JR:
 Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA

Li, XH:
 Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, LABioMed, Inst Translat Genom & Populat Sci,Dept Pediat, Torrance, CA 90509 USA

Theusch, E:
 Univ Calif San Francisco, Dept Pediat, Oakland, CA USA

Takeuchi, F:
 Natl Ctr Global Hlth & Med, Tokyo, Japan

Spracklen, CN:
 Univ N Carolina, Dept Genet, Chapel Hill, NC USA

 Univ Massachusetts, Dept Biostat & Epidemiol, Amherst, MA 01003 USA

Loukola, A:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland

Bollepalli, S:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland

Warner, SC:
 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

 Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England

Wang, YX:
 Beijing Inst Ophthalmol, Beijing Key Lab Ophthalmol & Visual Sci, Beijing, Peoples R China

 Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China

Wei, WB:
 Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China

Nutile, T:
 CNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy

Ruggiero, D:
 CNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy

 IRCCS Neuromed, Pozzilli, Isernia, Italy

Sung, YJ:
 Washington Univ, Dept Psychiat, St Louis, MO 63110 USA

Hung, YJ:
 Triserv Gen Hosp, Div Endocrinol & Metab, Songshan Branch, Taipei, Taiwan

Chen, SF:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis,Dept Epidemiol, Beijing, Peoples R China

Liu, FC:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis,Dept Epidemiol, Beijing, Peoples R China

Yang, JY:
 Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA

 Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL USA

Kentistou, KA:
 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Edinburgh, Midlothian, Scotland

Gorski, M:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany

 Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany

Brumat, M:
 Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

Meidtner, K:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

 German Ctr Diabet Res DZD, Neuherberg, Germany

Bielak, LF:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Smith, JA:
 Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA

 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Hebbar, P:
 Dasman Diabet Inst, Dept Genet & Bioinformat, Kuwait, Kuwait

Farmaki, AE:
 Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece

 UCL, Dept Populat Sci & Expt Med, London, England

Hofer, E:
 Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria

 Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria

Lin, MX:
 Univ N Carolina, Dept Bioinformat & Genom, Charlotte, NC USA

Xue, C:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA

Zhang, JF:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA

Concas, MP:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

Vaccargiu, S:
 UOS Sassari, Natl Res Council Italy, Inst Genet & Biomed Res, Sassari, Italy

van der Most, PJ:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

Pitkanen, N:
 Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

 Univ Turku, Ctr Populat Hlth Res, Turku, Finland

 Turku Univ Hosp, Turku, Finland

Cade, BE:
 Brigham & Womens Hosp, Sleep Med & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA

 Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA

Lee, J:
 Brigham & Womens Hosp, Sleep Med & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA

 Oneomics, Bucheon, South Korea

van der Laan, SW:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs Pharm & Biomed Genet, Cent Diagnost Lab, Utrecht, Netherlands

Chitrala, KN:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH,Biomed Res Ctr, Baltimore, MD 21224 USA

Weiss, S:
 Univ Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany

Zimmermann, ME:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany

Lee, JY:
 Oneomics, Bucheon, South Korea

Choi, HS:
 Hallym Univ, Dept Biomed Sci, Chunchon, South Korea

Nethander, M:
 Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med, Gothenburg, Sweden

 Univ Gothenburg, Sahlgrenska Acad, Bioinformat Core Facil, Gothenburg, Sweden

Freitag-Wolf, S:
 Univ Kiel, Inst Med Informat & Stat, Kiel, Germany

Southam, L:
 Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm Hlth, Neuherberg, Germany

 Wellcome Trust Sanger Inst, Hinxton, England

Rayner, NW:
 Wellcome Sanger Inst, Hinxton, England

 Univ Oxford, Wellcome Ctr Human Genet, Oxford, England

 Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm Hlth, Neuherberg, Germany

 Oxford Ctr Diabet Endocrinol & Metab, Oxford, England

Wang, CA:
 Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Med & Publ Hlth, Newcastle, NSW, Australia

Lin, SY:
 Taichung Vet Gen Hosp, Ctr Geriatr & Gerontol, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

 Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

 Natl Def Med Ctr, Sch Med, Taipei, Taiwan

Wang, JS:
 Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

 Natl Yang Ming Univ, Sch Med, Dept Med, Taipei, Taiwan

Couture, C:
 Univ Laval, Dept Kinesiol, Laval, PQ, Canada

Lyytikainen, LP:
 Fimlab Labs, Dept Clin Chem, Tampere, Finland

 Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland

Nikus, K:
 Tampere Univ Hosp, Heart Ctr, Dept Cardiol, Tampere, Finland

 Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiol, Tampere, Finland

Cuellar-Partida, G:
 Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia

Vestergaard, H:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

 Bornholms Hosp, Dept Med, Ronne, Denmark

Hildalgo, B:
 Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA

Giannakopoulou, O:
 Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

Cai, QY:
 Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA

Obura, MO:
 Amsterdam UMC, Dept Epidemiol & Biostat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

van Setten, J:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Cardiol, Utrecht, Netherlands

Li, XY:
 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

Schwander, K:
 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA

Terzikhan, N:
 Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

Shin, JH:
 Hallym Univ, Dept Biomed Sci, Chunchon, South Korea

Jackson, RD:
 Ohio State Univ, Div Endocrinol, Columbus, OH 43210 USA

Reiner, AP:
 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

Martin, LW:
 George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA

Chen, ZM:
 Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

 Univ Oxford, Nuffield Dept Populat Hearth, Epidemiol Studies Unit, Oxford, England

 Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford, England

Li, LM:
 Peking Univ, Sch Publ Hlth, Dept Epidemiol, Hlth Sci Ctr, Beijing, Peoples R China

Highland, HM:
 Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

Young, KL:
 Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

Kawaguchi, T:
 Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan

Thiery, J:
 Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany

 Univ Hosp Leipzig, Inst Lab Med, Leipzig, Germany

Bis, JC:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

Nadkarni, GN:
 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

Launer, LJ:
 NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA

Li, HX:
 Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China

Nalls, MA:
 NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA

 Data Tecn Int, Glen Echo, MD USA

Raitakari, OT:
 Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

 Univ Turku, Ctr Populat Hlth Res, Turku, Finland

 Turku Univ Hosp, Turku, Finland

 Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland

Ichihara, S:
 Jichi Med Univ, Dept Environm & Prevent Med, Sch Med, Shimotsuke, Tochigi, Japan

Wild, SH:
 Univ Edinburgh, Ctr Populat Hlth Sci, Usher Inst, Edinburgh, Midlothian, Scotland

Nelson, CP:
 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

 Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England

Campbell, H:
 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Edinburgh, Midlothian, Scotland

Jager, S:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

 German Ctr Diabet Res DZD, Neuherberg, Germany

Nabika, T:
 Shimane Univ, Dept Funct Pathol, Sch Med, Izumo, Shimane, Japan

Al-Mulla, F:
 Dasman Diabet Inst, Dept Genet & Bioinformat, Kuwait, Kuwait

Niinikoski, H:
 Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland

 Univ Turku, Turku, Finland

 Univ Turku, Dept Physiol, Turku, Finland

Braund, PS:
 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

 Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England

Kolcic, I:
 Univ Split, Fac Med, Split, Croatia

Kovacs, P:
 Univ Leipzig Med Ctr, Med Dept Endocrinol Nephrol Rheumatol 3, Leipzig, Germany

Giardoglou, T:
 Harokopio Univ, Dept Nutr Dietet, Athens, Greece

Katsuya, T:
 Osaka Univ, Dept Clin Gene Therapy, Grad Sch Med, Suita, Osaka, Japan

 Osaka Univ, Dept Geriatr & Gen Med, Grad Sch Med, Suita, Osaka, Japan

Bhatti, F:
 Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

de Kleijn, D:
 Univ Utrecht, Univ Med Ctr Utrecht, Dept Vasc Surg, Div Surg Specialties, Utrecht, Netherlands

de Borst, GJ:
 Univ Utrecht, Univ Med Ctr Utrecht, Dept Vasc Surg, Div Surg Specialties, Utrecht, Netherlands

Kim, EK:
 Yonsei Univ, Corneal Dystrophy Res Inst, Dept Ophthalmol, Coll Med, Seoul, South Korea

Adams, HHH:
 Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

 Univ Med Ctr Rotterdam, Dept Radiol & Nucl Med, Erasmus MC, Rotterdam, Netherlands

Ikram, MA:
 Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

Zhu, XF:
 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

Asselbergs, FW:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Cardiol, Utrecht, Netherlands

Kraaijeveld, AO:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Cardiol, Utrecht, Netherlands

Beulens, JWJ:
 Amsterdam UMC, Dept Epidemiol & Biostat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

 Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

Shu, XO:
 Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA

Rallidis, LS:
 Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Dept Cardiol 2, Athens, Greece

Pedersen, O:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

Hansen, T:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

Mitchell, P:
 Univ Sydney, Ctr Vis Res, Dept Ophthalmol, Sydney, NSW, Australia

 Univ Sydney, Westmead Inst, Sydney, NSW, Australia

Hewitt, AW:
 Univ Tasmania, Sch Med, Menzies Inst Med Res, Hobart, Tas, Australia

 Univ Melbourne, Ctr Eye Res Australia, Sydney, NSW, Australia

Kahonen, M:
 Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland

 Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland

Perusse, L:
 Univ Laval, Dept Kinesiol, Laval, PQ, Canada

 Univ Laval, Inst Nutr & Funct Foods INAF, Quebec City, PQ, Canada

Bouchard, C:
 Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA

Tonjes, A:
 Univ Leipzig Med Ctr, Med Dept Endocrinol Nephrol Rheumatol 3, Leipzig, Germany

Chen, YDI:
 Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, LABioMed, Inst Translat Genom & Populat Sci,Dept Pediat, Torrance, CA 90509 USA

Pennell, CE:
 Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Med & Publ Hlth, Newcastle, NSW, Australia

Mori, TA:
 Univ Western Australia, Fac Hlth & Med Sci, Med Sch, Perth, WA, Australia

Lieb, W:
 Univ Kiel, Inst Epidemiol, Kiel, Germany

Franke, A:
 Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

Ohlsson, C:
 Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med, Gothenburg, Sweden

 Sahlgrens Univ Hosp, Dept Drug Treatment, Gothenburg, Sweden

Mellstrom, D:
 Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Inst Med, Gothenburg, Sweden

 Univ Gothenburg, Sahlgrenska Acad, Inst Med, Geriatr Med, Gothenburg, Sweden

Cho, YS:
 Hallym Univ, Dept Biomed Sci, Chunchon, South Korea

Lee, H:
 Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea

Yuan, JM:
 Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, Pittsburgh, PA USA

 Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

Koh, WP:
 Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Programme, Singapore, Singapore

 ASTAR, Singapore Inst Clin Sci, Singapore, Singapore

Rhee, SY:
 Kyung Hee Univ, Dept Endocrinol & Metab, Sch Med, Seoul, South Korea

Woo, JT:
 Kyung Hee Univ, Dept Endocrinol & Metab, Sch Med, Seoul, South Korea

Heid, IM:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany

Stark, KJ:
 Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany

Volzke, H:
 Univ Med Greifswald, Inst Community Med, Greifswald, Germany

Homuth, G:
 Univ Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany

Evans, MK:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH,Biomed Res Ctr, Baltimore, MD 21224 USA

Zonderman, AB:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH,Biomed Res Ctr, Baltimore, MD 21224 USA

Polasek, O:
 Univ Split, Fac Med, Split, Croatia

Pasterkamp, G:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs Pharm & Biomed Genet, Cent Diagnost Lab, Utrecht, Netherlands

Hoefer, IE:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs Pharm & Biomed Genet, Cent Diagnost Lab, Utrecht, Netherlands

Redline, S:
 Brigham & Womens Hosp, Sleep Med & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA

 Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA

Pahkala, K:
 Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

 Univ Turku, Ctr Populat Hlth Res, Turku, Finland

 Turku Univ Hosp, Turku, Finland

 Univ Turku, Paavo Nurmi Ctr, Dept Phys Act & Hlth, Sports & Exercise Med Unit, Turku, Finland

Oldehinkel, AJ:
 Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands

Snieder, H:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

Biino, G:
 Natl Res Council Italy, Inst Mol Genet, Pavia, Italy

Schmidt, R:
 Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria

Schmidt, H:
 Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Graz, Austria

Chen, YE:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA

Bandinelli, S:
 Toscana Ctr, Local Hlth Unit, Florence, Italy

Dedoussis, G:
 Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece

Thanaraj, TA:
 Dasman Diabet Inst, Dept Genet & Bioinformat, Kuwait, Kuwait

Kardia, SLR:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Kato, N:
 Natl Ctr Global Hlth & Med, Tokyo, Japan

Schulze, MB:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

 German Ctr Diabet Res DZD, Neuherberg, Germany

 Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany

Girotto, G:
 Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy

Jung, B:
 Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany

Boger, CA:
 Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany

 Traunstein Hosp, Dept Nephrol Diabetol Rheumatol, Traunstein, Germany

 KfH Kidney Ctr Traunstein, Traunstein, Germany

Joshi, PK:
 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Edinburgh, Midlothian, Scotland

Bennett, DA:
 Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA

 Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL USA

De Jager, PL:
 Columbia Univ, Ctr Translat & Syst Neuroimmunol, Dept Neurol, Med Ctr, New York, NY USA

 Broad Inst, Program Med & Populat Genet, Cambridge, MA USA

Lu, XF:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis,Dept Epidemiol, Beijing, Peoples R China

Mamakou, V:
 Natl & Kapodistrian Univ Athens, Med Sch, Athens, Greece

 Dromokaiteio Psychiat Hosp, Athens, Greece

Brown, M:
 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Dept Epidemiol, Sch Publ Hlth, Houston, TX 77030 USA

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London, England

 Queen Mary Univ London, William Harvey Res Inst, Clin Pharmacol, London, England

Caulfield, MJ:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London, England

Munroe, PB:
 Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London, England

Guo, XQ:
 Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, LABioMed, Inst Translat Genom & Populat Sci,Dept Pediat, Torrance, CA 90509 USA

Ciullo, M:
 CNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy

 IRCCS Neuromed, Pozzilli, Isernia, Italy

Jonas, JB:
 Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany

 Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing, Peoples R China

 Inst Mol & Clin Ophthalmol Basel, Basel, Switzerland

Samani, NJ:
 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

 Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England

Kaprio, J:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland

Pajukanta, P:
 Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

Adair, LS:
 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA

 Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA

Bechayda, SA:
 Univ San Carlos, USC Off Populat Studies Fdn, Cebu, Philippines

 Univ San Carlos, Dept Anthropol Sociol & Hist, Cebu, Philippines

de Silva, HJ:
 Univ Kelaniya, Fac Med, Dept Med, Ragama, Sri Lanka

Wickremasinghe, AR:
 Univ Kelaniya, Fac Med, Dept Publ Hlth, Ragama, Sri Lanka

Krauss, RM:
 Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA

 Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

Wu, JY:
 Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

Zheng, W:
 Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA

den Hollander, AI:
 Radboud Univ Nijmegen, Dept Ophthalmol, Med Ctr, Nijmegen, Netherlands

Bharadwaj, D:
 Acad Sci & Innovat Res, CSIR Inst Genom & Integrat Biol Campus, New Delhi, India

 Jawaharlal Nehru Univ, Sch Biotechnol, Syst Genom Lab, New Delhi, India

Correa, A:
 Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA

Wilson, JG:
 Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA

Lind, L:
 Uppsala Univ, Dept Med Sci, Uppsala, Sweden

Heng, CK:
 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore

 Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore, Singapore

Nelson, AE:
 Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA

 Univ N Carolina, Dept Med, Chapel Hill, NC USA

Golightly, YM:
 Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA

 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA

 Univ N Carolina, Injury Prevent Res Ctr, Chapel Hill, NC USA

 Univ N Carolina, Div Phys Therapy, Chapel Hill, NC USA

Wilson, JF:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

 Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Edinburgh, Midlothian, Scotland

Penninx, B:
 VU Med Ctr Amsterdam, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

 Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands

Kim, HL:
 Ewha Womans Univ, Coll Med, Dept Biochem, Seoul, South Korea

Attia, J:
 Hunter Med Res Inst, Newcastle, NSW, Australia

 Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia

Scott, RJ:
 Hunter Med Res Inst, Newcastle, NSW, Australia

 Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia

Rao, DC:
 Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA

Arnett, DK:
 Univ Kentucky, Coll Publ Hlth, Lexington, KY USA

Walker, M:
 Newcastle Univ, Med Sch, Inst Cellular Med Diabet, Newcastle Upon Tyne, Tyne & Wear, England

Koistinen, HA:
 Finnish Inst Hlth & Welf, Dept Populat Hlth, Helsinki, Finland

 Univ Helsinki, Helsinki, Finland

 Helsinki Univ Hosp, Dept Med, Helsinki, Finland

 Minerva Fdn, Helsinki, Finland

Chandak, GR:
 CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad, India

 Acad Sci & Innovat Res AcSIR, New Delhi, India

Yajnik, CS:
 KEM Hosp & Res Ctr, Diabetol Res Ctr, Pune, Maharashtra, India

Mercader, JM:
 Harvard Med Sch, Boston, MA 02115 USA

 Broad Inst MIT & Harvard, Program Metab & Med, Cambridge, MA 02142 USA

 Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

Tusie-Luna, T:
 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City, DF, Mexico

 UNAM, Inst Invest Biomed, Ciudad De Mexico, Mexico

 Inst Invest Bimed UNAM, Unidad Biol Mol & Med Genom, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico

Aguilar-Salinas, CA:
 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metabol, Mexico City, DF, Mexico

 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Direcc Nutr, Mexico City, DF, Mexico

 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Estudios Enfermedades Metab, Mexico City, DF, Mexico

Villalpando, CG:
 Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico

 Ctr Estudios Diabet, Cuernavaca, Morelos, Mexico

Orozco, L:
 Inst Nacl Med Genom, Mexico City, DF, Mexico

Fornage, M:
 Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Brown Fdn Inst Mol Med, Houston, TX 77030 USA

 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA

Tai, ES:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

 Natl Univ Hlth Syst, Singapore, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

van Dam, RM:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

 Natl Univ Hlth Syst, Singapore, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

Lehtimaki, T:
 Fimlab Labs, Dept Clin Chem, Tampere, Finland

 Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland

Chaturvedi, N:
 UCL, MRC Unit Lifelong Hlth & Ageing, London, England

Yokota, M:
 Kurume Univ, Sch Med, Kurume, Fukuoka, Japan

Liu, J:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

Reilly, DF:
 Merck Sharp & Dohme Ltd, Kenilworth, NJ USA

McKnight, AJ:
 Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

Kee, F:
 Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

Jockel, KH:
 Univ Duisburg Essen, Inst Med Informat Biometrie & Epidemiol, Essen, Germany

McCarthy, MI:
 Genentech Inc, San Francisco, CA 94080 USA

 Univ Oxford, Wellcome Ctr Human Genet, Oxford, England

 Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England

Palmer, CNA:
 Univ Dundee, Ninwells Hosp & Med Sch, Populat Hlth & Genom, Dundee, Scotland

Vitart, V:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

Hayward, C:
 Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

Simonsick, E:
 NIA, Intramural Res Program, Baltimore, MD 21224 USA

van Duijn, CM:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

Lu, F:
 Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Wenzhou, Peoples R China

Qu, J:
 Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Wenzhou, Peoples R China

Hishigaki, H:
 Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Biomed Technol Res Ctr, Tokushima, Japan

Lin, X:
 Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China

Marz, W:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany

 Synlab Acad, Synlab, Mannheim, Germany

 Med Univ Graz, Clin Inst, Med & Chem Lab Diagnost, Graz, Austria

Parra, EJ:
 Univ Toronto Mississauga, Dept Anthropol, Mississauga, ON, Canada

Cruz, M:
 Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Hosp Especialidades, Unidad Invest Med Bioquim, Mexico City, DF, Mexico

Gudnason, V:
 Iceland Heart Assoc, Reykjavik, Iceland

 Univ Iceland, Fac Med, Reykjavik, Iceland

Tardif, JC:
 Montreal Heart Inst, Montreal, PQ, Canada

 Univ Montreal, Dept Med, Fac Med, Quebec City, PQ, Canada

Lettre, G:
 Montreal Heart Inst, Montreal, PQ, Canada

 Univ Montreal, Dept Med, Fac Med, Montreal, PQ, Canada

't Hart, LM:
 Amsterdam UMC, Dept Epidemiol & Biostat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

 Leiden Univ Med Ctr, Dept Cell & Chem Biol, Leiden, Netherlands

 Leiden Univ Med Ctr, Dept Biomed Data Sci, Sect Mol Epidemiol, Leiden, Netherlands

Elders, PJM:
 Amsterdam UMC, Dept Gen Practice & Elderly Care, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

Damrauer, SM:
 Univ Penn, Dept Surg, Philadelphia, PA 19104 USA

 Corporal Michael Crescenz VA Med Ctr, Philadelphia, PA USA

Kumari, M:
 Univ Essex, Inst Social & Econ Res, Colchester, Essex, England

Kivimaki, M:
 UCL, Dept Epidemiol & Publ Hlth, London, England

van der Harst, P:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

Spector, TD:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

Loos, RJF:
 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA

Province, MA:
 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA

Psaty, BM:
 Univ Washington, Dept Med Epidemiol & Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA USA

 Kaiser Permanent Washington Hlth Res Inst, Seattle, WA USA

Brandslund, I:
 Lillebaelt Hosp, Dept Clin Biochem, Vejle, Denmark

 Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark

Pramstaller, PP:
 Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, Bolzano, Italy

Christensen, K:
 Univ Southern Denmark, Danish Aging Res Ctr, Odense, Denmark

Ripatti, S:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland

 Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria

 Univ Helsinki, Fac Med, Publ Hlth, Helsinki, Finland

 Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

Widen, E:
 Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland

Hakonarson, H:
 Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

 Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

Grant, SFA:
 Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

 Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

 Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA

Kiemeney, LALM:
 Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands

de Graaf, J:
 Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands

Loeffler, M:
 Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany

 Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany

Kronenberg, F:
 Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria

 German Chron Kidney Dis Study, Innsbruck, Austria

Gu, DF:
 Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing, Peoples R China

 Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis,Dept Epidemiol, Beijing, Peoples R China

 Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China

Erdmann, J:
 Univ Lubeck, DZHK German Res Ctr Cardiovasc Res, Inst Cardiogenet, Partner Site Hamburg Lubeck Kiel, Lubeck, Germany

 Univ Heart Ctr Lubeck, Lubeck, Germany

Schunkert, H:
 Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany

 Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany

Franks, PW:
 Lund Univ, Diabet Ctr, Malmo, Sweden

Linneberg, A:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

 Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

Jukema, JW:
 Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands

 Netherlands Heart Inst, Utrecht, Netherlands

Khera, AV:
 Italian Natl Council Res IRGB CNR, Inst Genet & Biomed Res, Cagliari, Italy

 Broad Inst, Program Med & Populat Genet, Cambridge, MA USA

 Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

 Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA USA

 Harvard Med Sch, Dept Med, Boston, MA 02115 USA

Mannikko, M:
 Univ Oulu, Fac Med, Infrastruct Populat Studies, Northern Finland Birth Cohorts, Oulu, Finland

Jarvelin, MR:
 Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

 Univ Oulu, Fac Med, Ctr Life Course Hlth Res, Oulu, Finland

 Univ Oulu, Bioctr Oulu, Oulu, Finland

Kutalik, Z:
 Swiss Inst Bioinformat, Lausanne, Switzerland

 Univ Ctr Primary Care & Publ Hlth, Lausanne, Switzerland

Cucca, F:
 Italian Natl Council Res IRGB CNR, Inst Genet & Biomed Res, Cagliari, Italy

 Univ Sassari, Sassari, Italy

Mook-Kanamori, DO:
 Leiden Univ Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands

 Leiden Univ Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands

van Dijk, KW:
 Leiden Univ Med Ctr, Dept Internal Med, Div Endocrinol, Leiden, Netherlands

 Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands

 Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands

Watkins, H:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford, England

 Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Div OfCardiovasc Med, Oxford, England

Strachan, DP:
 St Georges Univ London, Populat Hlth Res Inst, London, England

Grarup, N:
 Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

Sever, P:
 Imperial Coll London, Natl Heart & Lung Inst, London, England

Poulter, N:
 Imperial Coll London, Sch Publ Hlth, London, England

Rotter, JI:
 Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, LABioMed, Inst Translat Genom & Populat Sci,Dept Pediat, Torrance, CA 90509 USA

Dantoft, TM:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark

Karpe, F:
 Univ Oxford, Churchill Hosp, OCDEM, Oxford, England

 Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford, England

Neville, MJ:
 Univ Oxford, Churchill Hosp, OCDEM, Oxford, England

 Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford, England

Timpson, NJ:
 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England

 Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England

Cheng, CY:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Ocular Epidemiol, Singapore, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore

Wong, TY:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Ocular Epidemiol, Singapore, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore

Khor, CC:
 Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

Sabanayagam, C:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Ocular Epidemiol, Singapore, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore

Peters, A:
 Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

 German Ctr Diabet Res DZD, Neuherberg, Germany

 DZHK German Ctr Cardiovasc Res, Munich Heart Alliance Partner Site, Munich, Germany

Gieger, C:
 Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

 Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

 German Ctr Diabet Res DZD, Neuherberg, Germany

Hattersley, AT:
 Univ Exeter, Univ Exeter Med Sch, Exeter, Devon, England

Pedersen, NL:
 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

Magnusson, PKE:
 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

Boomsma, DI:
 Vrije Univ Amsterdam, Dept Biol Psychol Behav & Movement Sci, Amsterdam, Netherlands

 VU Med Ctr Amsterdam, Amsterdam Publ Hlth, Amsterdam, Netherlands

 VU Med Ctr Amsterdam, Amsterdam Reprod & Dev Res Inst, Amsterdam, Netherlands

de Geus, EJC:
 Vrije Univ Amsterdam, Dept Biol Psychol Behav & Movement Sci, Amsterdam, Netherlands

 VU Med Ctr Amsterdam, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

Cupples, LA:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

 NHLBI, Framingham Heart Study, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA

van Meurs, JBJ:
 Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands

 Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

Ghanbari, M:
 Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

 Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Iran

Rsen, PGL:
 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA

 Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA

Huang, W:
 Chinese Natl Human Genome Ctr Shanghai, Dept Genet, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai, Peoples R China

Kim, YJ:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea

Tabara, Y:
 Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan

Wareham, NJ:
 Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England

Langenberg, C:
 Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England

Zeggini, E:
 Helmholtz Zentrum Munchen, Inst Translat Genom, German Res Ctr Environm Hlth, Neuherberg, Germany

 Wellcome Trust Sanger Inst, Hinxton, England

 Tech Univ Munich TUM, TUM Sch Med, Munich, Germany

 Klinikum Rechts Der Isar, Munich, Germany

Kuusisto, J:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

 Kuopio Univ Hosp, Kuopio, Finland

Laakso, M:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

 Kuopio Univ Hosp, Kuopio, Finland

Ingelsson, E:
 Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

 Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden

 Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

 Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA USA

Abecasis, G:
 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

 Regeneron Pharmaceut, Tarrytown, NY USA

Chambers, JC:
 Imperial Coll London, Dept Epidemiol & Biostat, London, England

 London North West Univ Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Southall, Middx, England

 Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore

 Imperial Coll Healthcare NHS Trust, Imperial Coll London, London, England

Kooner, JS:
 London North West Univ Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Southall, Middx, England

 Imperial Coll Healthcare NHS Trust, London, England

 Imperial Coll London, Natl Heart & Lung Inst, London, England

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England

de Vries, PS:
 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Dept Epidemiol, Sch Publ Hlth, Houston, TX 77030 USA

Morrison, AC:
 Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Dept Epidemiol, Sch Publ Hlth, Houston, TX 77030 USA

North, KE:
 Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

Daviglus, M:
 Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA

Kraft, P:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA USA

 Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA

Martin, NG:
 QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia

Whitfield, JB:
 QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia

Abbas, S:
 Ctr Noncommunicable Dis, Karachi, Pakistan

 Faisalabad Inst Cardiol, Faislabad, Pakistan

Saleheen, D:
 Ctr Noncommunicable Dis, Karachi, Pakistan

 Columbia Univ, Dept Med, Irving Med Ctr, New York, NY USA

 Columbia Univ, Dept Cardiol, Irving Med Ctr, New York, NY USA

Walters, RG:
 Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

 Univ Oxford, Nuffield Dept Populat Hearth, Epidemiol Studies Unit, Oxford, England

 Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford, England

 Univ Oxford, Big Data Inst, Oxford, England

Holmes, MV:
 Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

 Univ Oxford, Nuffield Dept Populat Hearth, Epidemiol Studies Unit, Oxford, England

 Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford, England

 Oxford Univ Hosp, Natl Inst Hlth Res, Oxford Biomed Res Ctr, Oxford, England

Black, C:
 Univ Aberdeen, Aberdeen Ctr Hlth Data Sci, Sch Med, Aberdeen, Scotland

Smith, BH:
 Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth & Genom, Dundee, Scotland

Justice, AE:
 Geisinger Hlth, Biomed & Translat Informat, Danville, PA USA

Baras, A:
 Regeneron Pharmaceut, Tarrytown, NY USA

Buring, JE:
 Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA

 Harvard Med Sch, Boston, MA 02115 USA

Ridker, PM:
 Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA

 Harvard Med Sch, Boston, MA 02115 USA

Chasman, DI:
 Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA

 Harvard Med Sch, Boston, MA 02115 USA

Kooperberg, C:
 Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

Wei, WQ:
 Vanderbilt Univ Sch Med, Dept Biomed Informat, Nashville, TN USA

Jarvik, GP:
 Univ Washington, Med Ctr, Dept Med Med Genet, Seattle, WA USA

Namjou, B:
 Cincinnati Childrens Hosp Med Ctr CCHMC, Ctr Autoimmune Genom & Etiol, Cincinnati, OH USA

Hayes, MG:
 Northwestern Univ, Dept Med, Div Endocrinol, Feinberg Sch Med, Chicago, IL 60611 USA

 Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA

 Northwestern Univ, Feinberg Sch Med, Ctr Genet Med, Chicago, IL 60611 USA

Ritchie, MD:
 Univ Penn, Inst Biomed Informat, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA

Jousilahti, P:
 Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

Salomaa, V:
 Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

Hveem, K:
 Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway

 Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Nursing, NTNU, Levanger, Norway

 Levanger Hosp, Nord Trondelag Hosp Trust, Dept Med, Levanger, Norway

Asvold, BO:
 Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway

 Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Nursing, NTNU, Levanger, Norway

 Trondheim Reg & Univ Hosp, Dept Endocrinol, St Olavs Hosp, Trondheim, Norway

Kubo, M:
 RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

Kamatani, Y:
 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

 Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Complex Trait Genom, Tokyo, Japan

Okada, Y:
 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

 Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan

 Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Stat Immunol, Osaka, Japan

 Osaka Univ, Inst Open & Transdisciplinary Res Initiat, Integrated Frontier Res Med Sci Div, Osaka, Japan

Murakami, Y:
 Univ Tokyo, Inst Med Sci, Div Mol Pathol, Tokyo, Japan

Thorsteinsdottir, U:
 Amgen Inc, deCODE Genet, Reykjavik, Iceland

 Univ Iceland, Fac Med, Reykjavik, Iceland

Stefansson, K:
 Amgen Inc, deCODE Genet, Reykjavik, Iceland

 Univ Iceland, Fac Med, Reykjavik, Iceland

Ho, YL:
 VA Boston Healthcare Syst, Boston, MA USA

Lynch, JA:
 VA Salt Lake City Hlth Care Syst, VA Informat & Comp Infrastruct, Salt Lake City, UT USA

 Univ Massachusetts, Boston, MA 02125 USA

Rader, DJ:
 Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

 Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Tsao, PS:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

 Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

 Stanford Univ, Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA

Chang, KM:
 Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA

 Corporal Michael J Crescenz VA Med Ctr, Philadelphia, PA USA

Cho, K:
 VA Boston Healthcare Syst, Boston, MA USA

 Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

O'Donnell, CJ:
 VA Boston Healthcare Syst, Boston, MA USA

 Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

Gaziano, JM:
 VA Boston Healthcare Syst, Boston, MA USA

 Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

Wilson, P:
 Atlanta VA Med Ctr, Atlanta, GA USA

 Emory Univ, Sch Med, Div Cardiol, Atlanta, GA USA

Rotimi, CN:
 NHGRI, Ctr Res Genom & GLobal Hearth, NIH, Bethesda, MD 20892 USA

Hazelhurst, S:
 Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa

 Univ Witwatersrand, Sch Elect & Informat Engn, Johannesburg, South Africa

Ramsay, M:
 Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa

 Univ Witwatersrand, Fac Hlth Sci, Natl Hlth Lab Serv, Div Human Genet, Johannesburg, South Africa

 Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa

Trembath, RC:
 Kings Coll London, Fac Life Sci & Med, Sch Basic & Med Biosci, London, England

van Heel, DA:
 Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England

Tamiya, G:
 Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi, Japan

Yamamoto, M:
 Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi, Japan

Kim, BJ:
 Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Cheongju, South Korea

Mohlke, KL:
 Univ N Carolina, Dept Genet, Chapel Hill, NC USA

Frayling, TM:
 Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter, Devon, England

Hirschhorn, JN:
 Boston Childrens Hosp, Endocrinol, Boston, MA USA

 Broad Inst, Med & Populat Genet, Cambridge, MA USA

 Harvard Med Sch, Dept Pediat, Boston, MA USA

 Harvard Med Sch, Dept Genet, Boston, MA USA

Kathiresan, S:
 Broad Inst, Program Med & Populat Genet, Cambridge, MA USA

 Harvard Med Sch, Dept Med, Boston, MA 02115 USA

 Massachusetts Gen Hosp, Dept Med, Ctr Genom Med, Boston, MA 02114 USA

Boehnke, M:
 Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

 Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Natarajan, P:
 Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA

 Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

 Massachusetts Gen Hosp, Harvard Med Sch, Cardiol Div, Boston, MA USA

 Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA

 Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA

Peloso, GM:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

Brown, CD:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

Morris, AP:
 Univ Manchester, Ctr Genet & Genom Versus Arthrit, Ctr Musculoskeletal Res, Div Musculoskeletal & Dermatol Sci, Manchester, Lancs, England

Assimes, TL:
 VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

 Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

 Stanford Univ, Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA

Deloukas, P:
 Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England

 Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London, England

 King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia

Sun, YV:
 Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

 Atlanta VA Hlth Care Syst, Decatur, GA USA

Willer, CJ:
 Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA

 Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

 Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
ISSN: 00280836
Editorial
NATURE PORTFOLIO, HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY, Reino Unido
Tipo de documento: Article
Volumen: 600 Número: 7890
Páginas: 675
WOS Id: 000728504500001
ID de PubMed: 34887591
imagen Green Submitted, Green Accepted

MÉTRICAS