Hepatitis A Outbreak Characteristics: A Comparison of Regions with Different Vaccination Strategies, Spain 2010-2018
Por:
Dominguez, A, Varela, C, Soldevila, N, Izquierdo, C, Guerrero, M, Penuelas, M, Martinez, A, Godoy, P, Borras, E, Rius, C, Torner, N, Avellon, AM, Castilla, J
Publicada:
1 nov 2021
Resumen:
We compared the cumulative incidence and characteristics of hepatitis A outbreaks in two groups of Spanish autonomous regions according to whether a universal or risk group vaccination strategy was followed. Outbreaks between 2010 and 2018 were analyzed. The cumulative incidence rate of outbreaks was estimated and compared by estimating the rate ratio (RR). The characteristics of the outbreaks and those of the first cases were compared. Adjusted OR (aOR) were calculated using a multivariate logistic regression model. Outbreak incidence was 16.04 per million persons in regions with universal vaccination and 20.76 in those with risk-group vaccination (RR 0.77; 95%CI 0.62-0.94). Imported outbreaks accounted for 65% in regions with universal vaccination and 28.7% in regions with risk-group vaccination (aOR 3.88; 95%CI 2.13-7.09). Adolescents and young adults aged 15-44 years and men who have sex with men were less frequently the first case of the outbreak in regions with a universal vaccination strategy (aOR 0.54; 95%CI 0.32-0.92 and 0.23; 95%CI 0.07-0.82, respectively). The cumulative incidence rate of outbreaks was lower in regions with universal vaccination. In all regions, independently of the vaccination strategy, activities to vaccinate persons belonging to high-risk groups for infection should be emphasized.
Filiaciones:
Dominguez, A:
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Varela, C:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Inst Salud Carlos III, Ctr Nacl Epidemiol, Madrid 28029, Spain
Soldevila, N:
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Izquierdo, C:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Guerrero, M:
Inst Salud Carlos III, Ctr Nacl Epidemiol, Madrid 28029, Spain
Penuelas, M:
Inst Salud Carlos III, Ctr Nacl Epidemiol, Madrid 28029, Spain
Martinez, A:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Godoy, P:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Borras, E:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Rius, C:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Agencia Salut Publ Barcelona, Barcelona 08023, Spain
Torner, N:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Avellon, AM:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid 28222, Spain
Castilla, J:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Inst Salud Publ Navarra IdiSNA, Pamplona 31003, Spain
Green Published, gold
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