Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia
Por:
Zhu, N, Santos-Santos, M, Illan-Gala, I, Montal, V, Estelles, T, Barroeta, I, Altuna, M, Arranz, J, Munoz, L, Belbin, O, Sala, I, Sanchez-Saudinos, MB, Subirana, A, Videla, L, Pegueroles, J, Blesa, R, Clarimon, J, Carmona-Iragui, M, Fortea, J, Lleo, A, Alcolea, D
Publicada:
10 dic 2021
Resumen:
Background: Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. Studies of glial fibrillary acidic protein (GFAP), an astrocytic damage marker, may help advance our understanding of different neurodegenerative diseases. In this study, we investigated the diagnostic performance of plasma GFAP (pGFAP), plasma neurofilament light chain (pNfL) and their combination for frontotemporal dementia (FTD) and Alzheimer's disease (AD) and their clinical utility in predicting disease progression.
Methods: pGFAP and pNfL concentrations were measured in 72 FTD, 56 AD and 83 cognitively normal (CN) participants using the Single Molecule Array technology. Of the 211 participants, 199 underwent cerebrospinal (CSF) analysis and 122 had magnetic resonance imaging. We compared cross-sectional biomarker levels between groups, studied their diagnostic performance and assessed correlation between CSF biomarkers, cognitive performance and cortical thickness. The prognostic performance was investigated, analyzing cognitive decline through group comparisons by tertile.
Results: Unlike pNfL, which was increased similarly in both clinical groups, pGFAP was increased in FTD but lower than in AD (all P < 0.01). Combination of both plasma markers improved the diagnostic performance to discriminate FTD from AD (area under the curve [AUC]: combination 0.78; pGFAP 0.7; pNfL 0.61, all P < 0.05). In FTD, pGFAP correlated with cognition, CSF and plasma NfL, and cortical thickness (all P < 0.05). The higher tertile of pGFAP was associated with greater change in MMSE score and poor cognitive outcome during follow-up both in FTD (1.40 points annually, hazard ratio [HR] 3.82, P < 0.005) and in AD (1.20 points annually, HR 2.26, P < 0.005).
Conclusions: pGFAP and pNfL levels differ in FTD and AD, and their combination is useful for distinguishing between the two diseases. pGFAP could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.
Filiaciones:
Zhu, N:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Santos-Santos, M:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Illan-Gala, I:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Montal, V:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Estelles, T:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Barroeta, I:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Altuna, M:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Arranz, J:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Munoz, L:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Belbin, O:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Sala, I:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Sanchez-Saudinos, MB:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Subirana, A:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Videla, L:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Fdn Catalana Sindrome, Ctr Med Down, Barcelona 08029, Spain
Pegueroles, J:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Blesa, R:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Clarimon, J:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Carmona-Iragui, M:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Fdn Catalana Sindrome, Ctr Med Down, Barcelona 08029, Spain
Fortea, J:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Fdn Catalana Sindrome, Ctr Med Down, Barcelona 08029, Spain
Lleo, A:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Autonomous Univ Barcelona, Barcelona 08913, Spain
Alcolea, D:
Univ Autonoma Barcelona, Inst Invest Biomed, Dept Neurol, St Pau Memory Unit,St Pau Hosp St Pau, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Neurodenerat C, Madrid 28031, Spain
Autonomous Univ Barcelona, Barcelona 08913, Spain
Green Published, gold
|