Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid
Por:
Bostrom, G, Freyhult, E, Virhammar, J, Alcolea, D, Tumani, H, Otto, M, Brundin, RM, Kilander, L, Lowenmark, M, Giedraitis, V, Lleo, A, von Arnim, CAF, Kultima, K, Ingelsson, M
Publicada:
1 ene 2021
Resumen:
Background: Neuroinflammatory processes are common in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but current knowledge is limited as to whether cerebrospinal fluid (CSF) levels of neuroinflammatory proteins are altered in these diseases.
Objective: To identify and characterize neuroinflammatory signatures in CSF from patients with AD, mild cognitive impairment (MCI), and FTD.
Methods: We used proximity extension assay and ANOVA to measure and compare levels of 92 inflammatory proteins in CSF from 42 patients with AD, 29 with MCI due to AD (MCI/AD), 22 with stable MCI, 42 with FTD, and 49 control subjects, correcting for age, gender, collection unit, and multiple testing.
Results: Levels of matrix metalloproteinase-10 (MMP-10) were increased in AD, MCI/AD, and FTD compared with controls (AD: fold change [FC] = 1.32, 95% confidence interval [CI] 1.14-1.53, q = 0.018; MCI/AD: FC = 1.53, 95% CI 1.20-1.94, q = 0.045; and FTD: FC = 1.42, 95% CI 1.10-1.83, q = 0.020). MMP-10 and eleven additional proteins were increased in MCI/AD, compared with MCI (q < 0.05). In FTD, 36 proteins were decreased, while none was decreased in AD or MCI/AD, compared with controls (q < 0.05).
Conclusion: In this cross-sectional multi-center study, we found distinct patterns of CSF inflammatory marker levels in FTD and in both early and established AD, suggesting differing neuroinflammatory processes in the two disorders.
Filiaciones:
Bostrom, G:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Geriatr, Box 564, SE-75122 Uppsala, Sweden
Freyhult, E:
Uppsala Univ, Dept Med Sci, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Uppsala, Sweden
Virhammar, J:
Uppsala Univ Hosp, Dept Neurosci, Neurol, Uppsala, Sweden
Alcolea, D:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Tumani, H:
Ulm Univ Hosp, Dept Neurol, Ulm, Germany
Otto, M:
Ulm Univ Hosp, Dept Neurol, Ulm, Germany
Brundin, RM:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Geriatr, Box 564, SE-75122 Uppsala, Sweden
Kilander, L:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Geriatr, Box 564, SE-75122 Uppsala, Sweden
Lowenmark, M:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Geriatr, Box 564, SE-75122 Uppsala, Sweden
Giedraitis, V:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Geriatr, Box 564, SE-75122 Uppsala, Sweden
Lleo, A:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
von Arnim, CAF:
Ulm Univ Hosp, Dept Neurol, Ulm, Germany
Georg August Univ, Univ Med Ctr Gottingen, Dept Geriatr Med, Gottingen, Germany
Kultima, K:
Uppsala Univ, Dept Med Sci, Clin Chem, Uppsala, Sweden
Ingelsson, M:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Geriatr, Box 564, SE-75122 Uppsala, Sweden
Green Published
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