Correlation between PlateletWorks(R) and PFA-100(R) for Measuring Platelet Function before Urgent Surgery in Patients with Chronic Antiplatelet Therapy
Por:
Anaya, R, Rodriguez, M, Gil, JM, Vilalta, N, Merchan-Galvis, A, Moral, V, Mateo, J, Martinez-Zapata, MJ
Publicada:
1 ene 2021
Resumen:
Hemostasis is crucial for reducing bleeding during surgical procedures. The points-of-care based on the platelet function test could be useful to minimize the complications related to chronic antiplatelet therapy during surgery. The present study is aimed at comparing two point-of-care platelet function devices-Platelet Function Analyzer PFA-100(R) (Siemens Canada, Mississauga, ON, Canada) and Plateletworks(R)(Helena Laboratories, Beaumont, TX, USA). Our objective is to evaluate if they provide comparable and useful information to manage anti-aggregate patients before surgery. We included patients with a femoral fracture receiving chronic antiplatelet therapy and a median age of 89 years (range from 70 to 98). A platelet function evaluation was performed on all patients before surgery using both devices-Plateletworks(R) and PFA-100(R). The correlation between Plateletworks(R) and PFA-100(R) was performed using Cohen's Kappa coefficient. Twenty consecutive patients participated in the trial; 16 patients were under treatment with 75 mg/day of clopidogrel, three with >300 mg/day of acetylsalicylic acid (ASA), and only one was in treatment with both antiplatelet agents. Cohen's Kappa coefficient was 0.327 comparing PFA-100(R)-ADP (adenosine diphosphate) and Plateletworks(R) and, 0.200 comparing PFA-100(R)-EPI (epinephrine) and Plateletworks(R). In conclusion, we found a weak concordance comparing PFA-100(R) and Plateletworks(R). This could partially be due to the advanced age of the included patients. However, given the limited sample size, more studies are necessary to confirm these results.
Filiaciones:
Anaya, R:
Hosp Santa Creu & Sant Pau, Anesthesiol Serv, Barcelona 08041, Spain
Rodriguez, M:
Hosp Santa Creu & Sant Pau, Anesthesiol Serv, Barcelona 08041, Spain
Gil, JM:
Hosp Santa Creu & Sant Pau, Anesthesiol Serv, Barcelona 08041, Spain
Vilalta, N:
Hosp Santa Creu & Sant Pau, Anesthesiol Serv, Barcelona 08041, Spain
Merchan-Galvis, A:
IIBSt Pau, Iberoamer Cochrane Ctr Publ Hlth & Clin Epidemiol, Barcelona 08025, Spain
Univ Cauca, Dept Med Social & Salud Familiar, Popayan 190003, Colombia
Moral, V:
Hosp Santa Creu & Sant Pau, Anesthesiol Serv, Barcelona 08041, Spain
Mateo, J:
Hosp Santa Creu & Sant Pau, Hematol Dept, Thrombosis & Hemostasis Unit, Barcelona 08041, Spain
Martinez-Zapata, MJ:
IIBSt Pau, Iberoamer Cochrane Ctr Publ Hlth & Clin Epidemiol, Barcelona 08025, Spain
Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Barcelona 08025, Spain
Green Published, gold
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