Position statement for a pragmatic approach to immunotherapeutics in patients with inflammatory skin diseases during the coronavirus disease 2019 pandemic and beyond
Por:
Beecker, J, Papp, KA, Dutz, J, Vender, RB, Gniadecki, R, Cooper, C, Gisondi, P, Gooderham, M, Hong, CH, Kirchhof, MG, Lynde, CW, Maari, C, Poulin, Y, Puig, L
Publicada:
1 abr 2021
Ahead of Print:
1 feb 2021
Resumen:
Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, a novel RNA virus that was declared a global pandemic on 11 March 2020. The efficiency of infection with SARS-CoV-2 is reflected by its rapid global spread. The SARS-CoV-2 pandemic has implications for patients with inflammatory skin diseases on systemic immunotherapy who may be at increased risk of infection or more severe infection. This position paper is a focused examination of current evidence considering the mechanisms of action of immunotherapeutic drugs in relation to immune response to SARS-CoV-2. We aim to provide practical guidance for dermatologists managing patients with inflammatory skin conditions on systemic therapies during the current pandemic and beyond. Considering the limited and rapidly evolving evidence, mechanisms of action of therapies, and current knowledge of SARS-CoV-2 infection, we propose that systemic immunotherapy can be continued, with special considerations for at risk patients or those presenting with symptoms.
Filiaciones:
Beecker, J:
Univ Ottawa, Ottawa, ON, Canada
Ottawa Hosp, Div Dermatol, Ottawa, ON, Canada
Ottawa Hosp Res Inst, Ottawa, ON, Canada
Prob Med Res Inc, Waterloo, ON, Canada
Papp, KA:
Prob Med Res Inc, Waterloo, ON, Canada
K Papp Clin Res, Waterloo, ON, Canada
Dutz, J:
Skin Care Ctr, Vancouver, BC, Canada
Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC, Canada
BC Childrens Hosp Res Inst, Skin Sci, Vancouver, BC, Canada
Vender, RB:
Dermatrials Res Inc, Hamilton, ON, Canada
McMaster Univ, Dept Med, Hamilton, ON, Canada
Gniadecki, R:
Prob Med Res Inc, Waterloo, ON, Canada
Univ Alberta, Fac Med & Dent, Dept Med, Div Dermatol, Edmonton, AB, Canada
Cooper, C:
Univ Ottawa, Ottawa, ON, Canada
Ottawa Hosp Res Inst, Ottawa, ON, Canada
Ottawa Hosp, Ottawa, ON, Canada
Reg Hepatitis Program, Ottawa, ON, Canada
Gisondi, P:
Univ Verona, Dept Med, Sect Dermatol & Venereol, Verona, Italy
Gooderham, M:
Prob Med Res Inc, Waterloo, ON, Canada
SKiN Centre Dermatol, Peterborough, ON, Canada
Hong, CH:
Prob Med Res Inc, Waterloo, ON, Canada
Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC, Canada
Dr Chih Ho Hong Med Inc, Surrey, BC, Canada
Kirchhof, MG:
Univ Ottawa, Ottawa, ON, Canada
Ottawa Hosp, Div Dermatol, Ottawa, ON, Canada
Lynde, CW:
Prob Med Res Inc, Waterloo, ON, Canada
Lynde Inst Dermatol, Markham, ON, Canada
Maari, C:
Innovaderm Res Inc, Montreal, PQ, Canada
Poulin, Y:
Ctr Rech Dermatol Quebec Metropolitain, Quebec City, PQ, Canada
Univ Laval, Dept Med, Hop Hotel Dieu Quebec, Quebec City, PQ, Canada
Puig, L:
Hosp Santa Creu & Sant Pau, Dept Dermatol, Barcelona, Spain
Bronze, Green Published
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