Sex differences in the behavioral variant of frontotemporal dementia: A new window to executive and behavioral reserve
Por:
Illan-Gala, I, Casaletto, KB, Borrego-Ecija, S, Arenaza-Urquijo, EM, Wolf, A, Cobigo, Y, Goh, SYM, Staffaroni, AM, Alcolea, D, Fortea, J, Blesa, R, Clarimon, J, Iulita, MF, Brugulat-Serrat, A, Llado, A, Grinberg, LT, Possin, K, Rankin, KP, Kramer, JH, Rabinovici, GD, Boxer, A, Seeley, WW, Sturm, VE, Gorno-Tempini, ML, Miller, BL, Sanchez-Valle, R, Perry, DC, Lleo, A, Rosen, HJ
Publicada:
1 ago 2021
Ahead of Print:
1 feb 2021
Resumen:
Introduction: Biological sex is an increasingly recognized factor driving clinical and structural heterogeneity in Alzheimer's disease, but its role in the behavioral variant of frontotemporal dementia (bvFTD) is unknown.
Methods: We included 216 patients with bvFTD and 235 controls with magnetic resonance imaging (MRI) from a large multicenter cohort. We compared the clinical characteristics and cortical thickness between men and women with bvFTD and controls. We followed the residuals approach to study behavioral and cognitive reserve.
Results: At diagnosis, women with bvFTD showed greater atrophy burden in the frontotemporal regions compared to men despite similar clinical characteristics. For a similar amount of atrophy, women demonstrated better-than-expected scores on executive function and fewer changes in apathy, sleep, and appetite than men.
Discussion: Our findings suggest that women might have greater behavioral and executive reserve than men, and neurodegeneration must be more severe in women to produce symptoms similar in severity to those in men.
Filiaciones:
Illan-Gala, I:
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Biomed Res Inst St Pau,Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Calif San Francisco, Equ Brain Hlth, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Casaletto, KB:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Borrego-Ecija, S:
Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain
Arenaza-Urquijo, EM:
Pasqual Maragall Fdn, Barcelona Eta Brain Res Ctr BBRC, Barcelona, Spain
Wolf, A:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Cobigo, Y:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Goh, SYM:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Staffaroni, AM:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Alcolea, D:
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Biomed Res Inst St Pau,Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Fortea, J:
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Biomed Res Inst St Pau,Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Blesa, R:
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Biomed Res Inst St Pau,Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Clarimon, J:
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Biomed Res Inst St Pau,Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Iulita, MF:
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Biomed Res Inst St Pau,Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Womens Brain Project, Guntershausen, Switzerland
Brugulat-Serrat, A:
Univ Calif San Francisco, Equ Brain Hlth, San Francisco, CA 94143 USA
Pasqual Maragall Fdn, Barcelona Eta Brain Res Ctr BBRC, Barcelona, Spain
Llado, A:
Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain
Grinberg, LT:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Univ Calif San Francisco, Memory & Aging Ctr, Dept Pathol, San Francisco, CA 94143 USA
Possin, K:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Rankin, KP:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Kramer, JH:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Rabinovici, GD:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Boxer, A:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Seeley, WW:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Univ Calif San Francisco, Memory & Aging Ctr, Dept Pathol, San Francisco, CA 94143 USA
Sturm, VE:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Gorno-Tempini, ML:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Miller, BL:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Sanchez-Valle, R:
Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain
Perry, DC:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Lleo, A:
Univ Autonoma Barcelona, Dept Neurol, St Pau Memory Unit, Biomed Res Inst St Pau,Hosp Santa Creu & St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Rosen, HJ:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Green Published, hybrid
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