Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature
Por:
Nieto-Benito, LM, Ciudad-Blanco, C, Sanmartin-Jimenez, O, Garces, JR, Rodriguez-Prieto, MA, Vilarrasa, E, de Eusebio-Murillo, E, Minano-Medrano, R, Escutia-Munoz, B, Gonzalez-Sixto, B, Artola-Igarza, JL, Rubio, AA, Redondo, P, Delgado-Jimenez, Y, Sanchez-Schmidt, JM, Allende-Markixana, I, Alonso-Pacheco, ML, Garcia-Bracamonte, B, Dobao, PD, Navarro-Tejedor, R, Suarez-Fernandez, R, Carnero-Gonzalez, L, Vazquez-Veiga, H, Barchino-Ortiz, L, Ruiz-Salas, V, Sanchez-Sambucety, P, Lopez-Estebaranz, JL, Botella-Estrada, R, Feal-Cortizas, C, Calatayud, AM, Gil, P, Morales-Gordillo, V, Toll-Abello, A, Ocerin-Guerra, I, Mayor-Arenal, M, Garcia-Donoso, C, Cano-Martinez, N, Sainz-Gaspar, L, Descalzo, MA, Garcia-Doval, I
Publicada:
1 may 2021
Ahead of Print:
1 feb 2021
Resumen:
Characterization of patients, surgery procedures and the risk factors for dermatofibrosarcoma protuberans (DFSP) recurrences is poorly defined. In this study, we aimed to describe the demographics, tumor characteristics and interventions of DFSP treated with Mohs micrographic surgery (MSS) to determine the rate and risk factors for recurrence. Data were collected from REGESMOHS, a nationwide prospective cohort study of patients treated with MMS in Spain. From July 2013 to February 2020, 163 patients with DFSP who underwent MMS were included. DFSP was mostly located on trunk and extremities. Recurrent tumors had deeper tumor invasion and required higher number of MMS stages. Paraffin MMS was the most frequently used technique. Overall recurrence rate was 0.97 cases/100 person-years (95% IC = 0.36-2.57). No differences were found in epidemiological, tumor, surgery characteristics or surgical technique (frozen or paraffin MMS [p = 0.6641]) in terms of recurrence. Median follow-up time was 28.6 months with 414 patient-years of follow-up. In conclusion, we found an overall low recurrence rate of DFSP treated with MMS. None of the studied risk factors, including MMS techniques, was associated with higher risk for recurrence.
Filiaciones:
Nieto-Benito, LM:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Ciudad-Blanco, C:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Hosp La Zarzuela, Madrid, Spain
Sanmartin-Jimenez, O:
Inst Valenciano Oncol, Valencia, Spain
Garces, JR:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Ctr Med Teknon, Barcelona, Spain
Rodriguez-Prieto, MA:
Complejo Asistencial Univ Leon, Leon, Spain
Vilarrasa, E:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Ctr Med Teknon, Barcelona, Spain
de Eusebio-Murillo, E:
Complejo Hosp Univ Guadalajara, Guadalajara, Spain
Minano-Medrano, R:
Hosp Univ Fdn Alcorcon, Madrid, Spain
Escutia-Munoz, B:
Hosp Univ La Fe, Valencia, Spain
Gonzalez-Sixto, B:
Complexo Univ Hosp Pontevedra, Pontevedra, Spain
Artola-Igarza, JL:
Hosp Galdakao, Galdakao, Spain
Rubio, AA:
Hosp Manises, Valencia, Spain
Redondo, P:
Clin Univ Navarra, Pamplona, Spain
Delgado-Jimenez, Y:
Hosp Univ Quiron Salud, Madrid, Spain
Hosp Univ La Princesa, Madrid, Spain
Sanchez-Schmidt, JM:
Hosp Mar, Barcelona, Spain
Allende-Markixana, I:
Hosp Univ Cruces, Baracaldo, Spain
Alonso-Pacheco, ML:
Hosp La Paz, Madrid, Spain
Garcia-Bracamonte, B:
Hosp Univ Doce Octubre, Madrid, Spain
Dobao, PD:
Hosp Infanta Leonor, Madrid, Spain
Navarro-Tejedor, R:
Hosp Univ La Princesa, Madrid, Spain
Suarez-Fernandez, R:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Carnero-Gonzalez, L:
Hosp Univ Araba, Vitoria, Spain
Vazquez-Veiga, H:
Complexo Hosp Univ Santiago, Santiago de Compostela, Spain
Barchino-Ortiz, L:
Hosp La Zarzuela, Madrid, Spain
Ruiz-Salas, V:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Sanchez-Sambucety, P:
Complejo Asistencial Univ Leon, Leon, Spain
Lopez-Estebaranz, JL:
Hosp Univ Fdn Alcorcon, Madrid, Spain
Botella-Estrada, R:
Hosp Univ La Fe, Valencia, Spain
Feal-Cortizas, C:
Complexo Univ Hosp Pontevedra, Pontevedra, Spain
Calatayud, AM:
Hosp Manises, Valencia, Spain
Gil, P:
Clin Univ Navarra, Pamplona, Spain
Morales-Gordillo, V:
Hosp Univ Quiron Salud, Madrid, Spain
Toll-Abello, A:
Hosp Mar, Barcelona, Spain
Ocerin-Guerra, I:
Hosp Univ Cruces, Baracaldo, Spain
Mayor-Arenal, M:
Hosp La Paz, Madrid, Spain
Garcia-Donoso, C:
Hosp Univ Doce Octubre, Madrid, Spain
Cano-Martinez, N:
Hosp La Zarzuela, Madrid, Spain
Hosp Infanta Leonor, Madrid, Spain
Sainz-Gaspar, L:
Complexo Hosp Univ Santiago, Santiago de Compostela, Spain
Descalzo, MA:
Fdn Piel Sana Acad Espanola Dermatol, Madrid, Spain
Garcia-Doval, I:
Fdn Piel Sana Acad Espanola Dermatol, Madrid, Spain
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