Epigenetic loss of m(1)A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome

Por: Esteve-Puig, R, Climent, F, Pineyro, D, Domingo-Domenech, E, Davalos, V, Encuentra, M, Rea, A, Espejo-Herrera, N, Soler, M, Lopez, M, Ortiz-Barahona, V, Tapia, G, Navarro, JT, Cid, J, Farre, L, Villanueva, A, Casanova, I, Mangues, R, Santamarina-Ojeda, P, Fernandez, AF, Fraga, MF, Piris, MA, Kol, N, Avrahami, C, Moshitch-Moshkovitz, S, Rechavi, G, Sureda, A, Esteller, M

---

Publicada: 18 feb 2021

---

---

Filiaciones:
Esteve-Puig, R:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

Climent, F:
 Univ Barcelona, Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Dept Pathol, Barcelona, Spain

Pineyro, D:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

 Ctr Invest Biomed Red CIBER Canc CIBERONC, Madrid, Spain

Domingo-Domenech, E:
 Hosp Duran & Reynals, Catalan Inst Oncol ICO, Clin Hematol Dept, Ave Gran Via Hosp 199-203, Barcelona 08909, Catalonia, Spain

Davalos, V:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

Encuentra, M:
 Hosp Duran & Reynals, Catalan Inst Oncol ICO, Clin Hematol Dept, Ave Gran Via Hosp 199-203, Barcelona 08909, Catalonia, Spain

Rea, A:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

Espejo-Herrera, N:
 Univ Barcelona, Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Dept Pathol, Barcelona, Spain

Soler, M:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

Lopez, M:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

Ortiz-Barahona, V:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

Tapia, G:
 Univ Autonoma Barcelona, Dept Pathol, Inst Invest Ciencies Salut Germans Trias & Pujol, Barcelona, Spain

Navarro, JT:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

 Univ Autonoma Barcelona, Catalan Inst Oncol ICO, Dept Hematol, Hosp Univ Germans Trias & Pujol, Barcelona, Spain

Cid, J:
 Univ Barcelona, Apheresis & Cellular Therapy Unit, Dept Hemotherapy & Hemostasis ICMHO, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Hos, Barcelona, Spain

Farre, L:
 Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Program Canc Therapeut Resistance ProCURE, Barcelona, Spain

 Oswaldo Cruz Fdn CPQGM FIOCRUZ, Goncalo Moniz Res Ctr, Lab Expt Pathol LAPEX, Salvador, BA, Brazil

Villanueva, A:
 Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Program Canc Therapeut Resistance ProCURE, Barcelona, Spain

Casanova, I:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

 CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid, Spain

 Hosp Santa Creu & Sant Pau, Biomed Res Inst Sant Pau IIB St Pau, Barcelona, Spain

Mangues, R:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

 CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid, Spain

 Hosp Santa Creu & Sant Pau, Biomed Res Inst Sant Pau IIB St Pau, Barcelona, Spain

Santamarina-Ojeda, P:
 Univ Oviedo, Nanomat & Nanotechnol Res Ctr, Spanish Natl Res Council CINN CSIC, Oviedo, Spain

 Univ Oviedo, Hlth Res Inst Asturias ISPA, Oviedo, Spain

 Univ Oviedo, Inst Oncol Asturias IUOPA, Oviedo, Spain

 Univ Oviedo, Dept Organisms & Syst Biol BOS, Oviedo, Spain

Fernandez, AF:
 Univ Oviedo, Nanomat & Nanotechnol Res Ctr, Spanish Natl Res Council CINN CSIC, Oviedo, Spain

 Univ Oviedo, Hlth Res Inst Asturias ISPA, Oviedo, Spain

 Univ Oviedo, Inst Oncol Asturias IUOPA, Oviedo, Spain

 Univ Oviedo, Dept Organisms & Syst Biol BOS, Oviedo, Spain

Fraga, MF:
 Univ Oviedo, Nanomat & Nanotechnol Res Ctr, Spanish Natl Res Council CINN CSIC, Oviedo, Spain

 Univ Oviedo, Hlth Res Inst Asturias ISPA, Oviedo, Spain

 Univ Oviedo, Inst Oncol Asturias IUOPA, Oviedo, Spain

 Univ Oviedo, Dept Organisms & Syst Biol BOS, Oviedo, Spain

Piris, MA:
 Ctr Invest Biomed Red CIBER Canc CIBERONC, Madrid, Spain

 Fdn Jimenez Diaz Univ Hosp, Serv Pathol, Madrid, Spain

Kol, N:
 Chaim Sheba Med Ctr, Canc Res Ctr, Tel Hashomer, Israel

 Chaim Sheba Med Ctr, Wohl Inst Translat Med, Tel Hashomer, Israel

 Tel Aviv Univ, Dept Human Genet & Biochem, Sackler Fac Med, Tel Aviv, Israel

Avrahami, C:
 Chaim Sheba Med Ctr, Canc Res Ctr, Tel Hashomer, Israel

 Chaim Sheba Med Ctr, Wohl Inst Translat Med, Tel Hashomer, Israel

 Tel Aviv Univ, Dept Human Genet & Biochem, Sackler Fac Med, Tel Aviv, Israel

Moshitch-Moshkovitz, S:
 Chaim Sheba Med Ctr, Canc Res Ctr, Tel Hashomer, Israel

 Chaim Sheba Med Ctr, Wohl Inst Translat Med, Tel Hashomer, Israel

 Tel Aviv Univ, Dept Human Genet & Biochem, Sackler Fac Med, Tel Aviv, Israel

Rechavi, G:
 Chaim Sheba Med Ctr, Canc Res Ctr, Tel Hashomer, Israel

 Chaim Sheba Med Ctr, Wohl Inst Translat Med, Tel Hashomer, Israel

 Tel Aviv Univ, Dept Human Genet & Biochem, Sackler Fac Med, Tel Aviv, Israel

Sureda, A:
 Hosp Duran & Reynals, Catalan Inst Oncol ICO, Clin Hematol Dept, Ave Gran Via Hosp 199-203, Barcelona 08909, Catalonia, Spain

Esteller, M:
 Josep Carreras Leukaemia Res Inst IJC, Carretera Can Ruti,Cami Escoles S-N, Barcelona 08916, Catalonia, Spain

 Ctr Invest Biomed Red CIBER Canc CIBERONC, Madrid, Spain

 Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

 Univ Barcelona, Sch Med & Hlth Sci, Physiol Sci Dept, Barcelona, Spain