Clinical Usefulness of Anthropometric Indices to Predict the Presence of Prediabetes. Data from the ILERVAS Cohort
Por:
Sanchez, M, Sanchez, E, Bermudez-Lopez, M, Torres, G, Farras-Salles, C, Pamplona, R, Castro-Boque, E, Valdivielso, JM, Purroy, F, Martinez-Alonso, M, Godoy, P, Mauricio, D, Fernandez, E, Hernandez, M, Rius, F, Lecube, A
Publicada:
1 mar 2021
Resumen:
Prediabetes is closely related to excess body weight and adipose distribution. For this reason, we aimed to assess and compare the diagnostic usefulness of ten anthropometric adiposity indices to predict prediabetes. Cross-sectional study with 8188 overweight subjects free of type 2 diabetes from the ILERVAS project (NCT03228459). Prediabetes was diagnosed by levels of glycated hemoglobin (HbA1c). Total body adiposity indices [BMI, Clinica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) and Deurenberg's formula] and abdominal adiposity (waist and neck circumferences, conicity index, waist to height ratio, Bonora's equation, A body shape index, and body roundness index) were calculated. The area under the receiver-operating characteristic (ROC) curve, the best cutoff and the prevalence of prediabetes around this value were calculated for every anthropometric index. All anthropometric indices other than the A body adiposity were higher in men and women with prediabetes compared with controls (p < 0.001 for all). In addition, a slightly positive correlation was found between indices and HbA1c in both sexes (r <= 0.182 and p <= 0.026 for all). None of the measures achieved acceptable levels of discrimination in ROC analysis (area under the ROC <= 0.63 for all). Assessing BMI, the prevalence of prediabetes among men increased from 20.4% to 36.2% around the cutoff of 28.2 kg/m(2), with similar data among women (from 29.3 to 44.8% with a cutoff of 28.6 kg/m(2)). No lonely obesity index appears to be the perfect biomarker to use in clinical practice to detect individuals with prediabetes.
Filiaciones:
Sanchez, M:
Univ Lleida, IRBLleida, Obes Diabet & Metab ODIM Res Grp, Endocrinol & Nutr Dept,Univ Hosp Arnau de Vilanov, Rovira Roure 80, Lleida 25198, Spain
Sanchez, E:
Univ Lleida, IRBLleida, Obes Diabet & Metab ODIM Res Grp, Endocrinol & Nutr Dept,Univ Hosp Arnau de Vilanov, Rovira Roure 80, Lleida 25198, Spain
Bermudez-Lopez, M:
Univ Lleida, RedinRen ISCIII, IRBLleida, Vasc & Renal Translat Res Grp, Lleida 25198, Spain
Torres, G:
Univ Lleida, IRBLleida, Translat Res Resp Med, Resp Dept,Univ Hosp Arnau de Vilanova Santa Maria, Lleida 25198, Spain
Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid 28029, Spain
Farras-Salles, C:
IRBLleida, Appl Epidemiol Res Grp, Lleida 25007, Spain
Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Lleida, Inst Catala Salut, Lleida 25007, Spain
Pamplona, R:
Univ Lleida, Expt Med Dept, IRBLleida, Lleida 25198, Spain
Castro-Boque, E:
Univ Lleida, RedinRen ISCIII, IRBLleida, Vasc & Renal Translat Res Grp, Lleida 25198, Spain
Valdivielso, JM:
Univ Lleida, RedinRen ISCIII, IRBLleida, Vasc & Renal Translat Res Grp, Lleida 25198, Spain
Purroy, F:
Univ Lleida, Univ Hosp Arnau de Vilanova, Stroke Unit, IRBLleida,Clin Neurosci Grp, Lleida 25198, Spain
Martinez-Alonso, M:
Univ Lleida, Biostat Unit, IRBLleida, Syst Biol & Stat Methods Biomed Res Grp, Lleida 25198, Spain
Godoy, P:
IRBLleida, Appl Epidemiol Res Grp, Lleida 25007, Spain
Mauricio, D:
Hosp Santa Creu & Sant Pau, Dept Endocrinol & Nutr, Barcelona 08041, Spain
Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain
Fernandez, E:
Univ Lleida, RedinRen ISCIII, IRBLleida, Vasc & Renal Translat Res Grp, Lleida 25198, Spain
Hernandez, M:
Univ Lleida, IRBLleida, Obes Diabet & Metab ODIM Res Grp, Endocrinol & Nutr Dept,Univ Hosp Arnau de Vilanov, Rovira Roure 80, Lleida 25198, Spain
Rius, F:
Univ Lleida, IRBLleida, Obes Diabet & Metab ODIM Res Grp, Endocrinol & Nutr Dept,Univ Hosp Arnau de Vilanov, Rovira Roure 80, Lleida 25198, Spain
Lecube, A:
Univ Lleida, IRBLleida, Obes Diabet & Metab ODIM Res Grp, Endocrinol & Nutr Dept,Univ Hosp Arnau de Vilanov, Rovira Roure 80, Lleida 25198, Spain
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