Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study
Por:
Fernandez-Castillejo, S, Pedret, A, Catalan, U, Valls, RM, Farras, M, Rubio, L, Castaner, O, Macia, A, Fito, M, Motilva, MJ, Covas, MI, Giera, M, Remaley, AT, Sola, R
Publicada:
1 may 2021
Ahead of Print:
1 mar 2021
Resumen:
Scope The lipidomic analysis of high-density lipoprotein (HDL) could be useful to identify new biomarkers of HDL function.
Methods and results A randomized, controlled, double-blind, crossover trial (33 hypercholesterolaemic subjects) is performed with a control virgin olive oil (VOO), VOO enriched with its own phenolic compounds (FVOO), or VOO enriched with additional phenolic compounds from thyme (FVOOT) for 3 weeks. HDL lipidomic analyses are performed using the Lipidyzer platform. VOO and FVOO intake increase monounsaturated-fatty acids (FAs) and decrease saturated and polyunsaturated FAs in triacylglyceride (TAG) species, among others species. In contrast, FVOOT intake does not induce these FAs changes. The decrease in TAG52:3(FA16:0) after VOO intake and the decrease in TAG52:5(FA18:2) after FVOO intake are inversely associated with changes in HDL resistance to oxidation. After FVOO intake, the decrease in TAG54:6(FA18:2) in HDL is inversely associated with changes in HDL cholesterol efflux capacity.
Conclusion VOO and FVOO consumption has an impact on the HDL lipidome, in particular TAG species. Although TAGs are minor components of HDL mass, the observed changes in TAG modulated HDL functionality towards a cardioprotective mode. The assessment of the HDL lipidome is a valuable approach to identify and characterize new biomarkers of HDL function.
Filiaciones:
Fernandez-Castillejo, S:
Univ Rovira & Virgili, Dept Medicina & Cirurgia, Fac Med & Ciencies Salut, Oxidacio Malalties Cardiovasc NFOC Salut,Grup Nut, Reus 43201, Spain
Unitat Nutricio & Salut, Ctr Tecnol Catalunya, Eurecat, Reus 43204, Spain
Pedret, A:
Univ Rovira & Virgili, Dept Medicina & Cirurgia, Fac Med & Ciencies Salut, Oxidacio Malalties Cardiovasc NFOC Salut,Grup Nut, Reus 43201, Spain
Unitat Nutricio & Salut, Ctr Tecnol Catalunya, Eurecat, Reus 43204, Spain
Catalan, U:
Univ Rovira & Virgili, Dept Medicina & Cirurgia, Fac Med & Ciencies Salut, Oxidacio Malalties Cardiovasc NFOC Salut,Grup Nut, Reus 43201, Spain
Unitat Nutricio & Salut, Ctr Tecnol Catalunya, Eurecat, Reus 43204, Spain
Valls, RM:
Univ Rovira & Virgili, Dept Medicina & Cirurgia, Fac Med & Ciencies Salut, Oxidacio Malalties Cardiovasc NFOC Salut,Grup Nut, Reus 43201, Spain
Farras, M:
Inst Recerca Hosp Santa Creu & Sant Pau, Inst dInvest Biomed IIB, Barcelona 08041, Spain
Inst Salud Carlos III, CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid 28029, Spain
Rubio, L:
Univ Lleida, Dept Food Technol, XaRTA TPV, Escola Tecn Super Enginyeria Agraria,Agrotecnio C, Avda Alcalde Rovira Roure 191, Catalonia 25198, Lleida, Spain
Castaner, O:
Hosp Mar Med Res Inst, Cardiovasc Risk & Nutr Res Grp, IMIM, Barcelona 08003, Spain
Univ Pompeu Fabra, PhD Program Biomed, Barcelona 08005, Spain
Inst Salud Carlos III, Consorcio CIBER MP Fisiopatol Obesidad & Nutr CIB, Madrid 28029, Spain
Macia, A:
Univ Lleida, Dept Food Technol, XaRTA TPV, Escola Tecn Super Enginyeria Agraria,Agrotecnio C, Avda Alcalde Rovira Roure 191, Catalonia 25198, Lleida, Spain
Fito, M:
Hosp Mar Med Res Inst, Cardiovasc Risk & Nutr Res Grp, IMIM, Barcelona 08003, Spain
Univ Pompeu Fabra, PhD Program Biomed, Barcelona 08005, Spain
Inst Salud Carlos III, Consorcio CIBER MP Fisiopatol Obesidad & Nutr CIB, Madrid 28029, Spain
Motilva, MJ:
Univ La Rioja, Inst Ciencias Vid & Vino ICVV, Consejo Super Invest Cient CSIC, Burgos Km 6,LO-20 Salida 13, Logrono 26007, La Rioja, Spain
Covas, MI:
Hosp Mar Med Res Inst, Cardiovasc Risk & Nutr Res Grp, IMIM, Barcelona 08003, Spain
NUPROAS Handelsbolag, NUPROAS HB, Nacka, Sweden
Giera, M:
Leiden Univ, Ctr Prote & Metabol, Med Ctr, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
Remaley, AT:
NIH, Dept Lab Med Clin Ctr, Bethesda, MD 20814 USA
Lung & Blood Inst Natl Inst Hlth, Pulm Branch Natl Heart, Lipoprotein Metab Sect Cardio, Bethesda, MD 20814 USA
Sola, R:
Univ Rovira & Virgili, Dept Medicina & Cirurgia, Fac Med & Ciencies Salut, Oxidacio Malalties Cardiovasc NFOC Salut,Grup Nut, Reus 43201, Spain
Inst Invest Sanitaria Pere Virgili IISPV, IISPV, Reus 43204, Spain
Hosp Univ Sant Joan Reus, Reus 43204, Spain
Green Published, hybrid
|