Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment, a latent class analysis
Por:
Roberto, N, Portella, MJ, Marquie, M, Alegret, M, Hernandez, I, Mauleon, A, Rosende-Roca, M, Abdelnour, C, de Antonio, EE, Gil, S, Tartari, JP, Vargas, L, Espinosa, A, Ortega, G, Perez-Cordon, A, Sanabria, A, Orellana, A, de Rojas, I, Moreno-Grau, S, Montrreal, L, Alarcon-Martin, E, Ruiz, A, Tarraga, L, Boada, M, Valero, S
Publicada:
19 mar 2021
Resumen:
Neuropsychiatric symptoms (NPS) have been recently addressed as risk factors of conversion to Alzheimer's disease (AD) and other dementia types in patients diagnosed with Mild Cognitive Impairment (MCI). Our aim was to determine profiles based on the prominent NPS in MCI patients and to explore the predictive value of these profiles on conversion to specific types of dementia. A total of 2137 MCI patients monitored in a memory clinic were included in the study. Four NPS profiles emerged (classes), which were defined by preeminent symptoms: Irritability, Apathy, Anxiety/Depression and Asymptomatic. Irritability and Apathy were predictors of conversion to dementia (HR =1.43 and 1.56, respectively). Anxiety/depression class showed no risk effect of conversion when compared to Asymptomatic class. Irritability class appeared as the most discriminant neuropsychiatric condition to identify non-AD converters (i.e., frontotemporal dementia, vascular dementia, Parkinson's disease and dementia with Lewy Bodies). The findings revealed that consistent subgroups of MCI patients could be identified among comorbid basal NPS. The preeminent NPS showed to behave differentially on conversion to dementia, beyond AD. Therefore, NPS should be used as early diagnosis facilitators, and should also guide clinicians to detect patients with different illness trajectories in the progression of MCI.
Filiaciones:
Roberto, N:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Univ Autnoma Barcelona UAB, Dept Psychiat & Forens Med, Barcelona, Spain
Portella, MJ:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Univ Autnoma Barcelona UAB, Dept Psychiat & Forens Med, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIBSant Pau, Dept Psychiat, St Antoni M Claret 167, Barcelona 08025, Catalonia, Spain
Networking Res Ctr Mental Hlth CIBERSAM, Madrid, Spain
Marquie, M:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Alegret, M:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Hernandez, I:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Mauleon, A:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Rosende-Roca, M:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Abdelnour, C:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
de Antonio, EE:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Gil, S:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Tartari, JP:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Vargas, L:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Espinosa, A:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Ortega, G:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Perez-Cordon, A:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Sanabria, A:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Orellana, A:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Univ Autnoma Barcelona UAB, Dept Psychiat & Forens Med, Barcelona, Spain
de Rojas, I:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Moreno-Grau, S:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Montrreal, L:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Alarcon-Martin, E:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Ruiz, A:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Tarraga, L:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Boada, M:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Valero, S:
Univ Internac Catalunya UIC, Inst Catala Neurociencies Aplicades, Barcelona Alzheimer Treatment & Res Ctr, Res Ctr & Memory Clin,Fundacio ACE, Gran Via Carles III,85 Bis, Barcelona 08028, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
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