(r)HDL in theranostics: how do we apply HDL's biology for precision medicine in atherosclerosis management?dagger
Por:
Uribe, KB, Benito-Vicente, A, Martin, C, Blanco-Vaca, F, Rotllan, N
Publicada:
7 may 2021
Ahead of Print:
1 mar 2021
Resumen:
High-density lipoproteins (HDL) are key players in cholesterol metabolism homeostasis since they are responsible for transporting excess cholesterol from peripheral tissues to the liver. Imbalance in this process, due to either excessive accumulation or impaired clearance, results in net cholesterol accumulation and increases the risk of cardiovascular disease (CVD). Therefore, significant effort has been focused on the development of therapeutic tools capable of either directly or indirectly enhancing HDL-guided reverse cholesterol transport (RCT). More recently, in light of the emergence of precision nanomedicine, there has been renewed research interest in attempting to take advantage of the development of advanced recombinant HDL (rHDL) for both therapeutic and diagnostic purposes. In this review, we provide an update on the different approaches that have been developed using rHDL, focusing on the rHDL production methodology and rHDL applications in theranostics. We also compile a series of examples highlighting potential future perspectives in the field.
Filiaciones:
Uribe, KB:
Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biomat CIC BiomaGUNE, Paseo Miramon 182, Donostia San Sebastian 20014, Spain
Benito-Vicente, A:
CSIC, Inst Biofis UPV EHU, Apdo 644, Bilbao 48080, Spain
Univ Basque Country, Dept Bioquim, Apdo 644, Bilbao 48080, Spain
Martin, C:
CSIC, Inst Biofis UPV EHU, Apdo 644, Bilbao 48080, Spain
Univ Basque Country, Dept Bioquim, Apdo 644, Bilbao 48080, Spain
Blanco-Vaca, F:
Hosp Santa Creu & St Pau Inst Invest Biomed IIB S, Serv Bioquim, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Barcelona, Spain
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Barcelona, Spain
Inst Invest Biomed IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Barcelona 08025, Spain
Rotllan, N:
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Barcelona, Spain
Inst Invest Biomed IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Barcelona 08025, Spain
Green Published, hybrid
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