Quantitative evaluation of oculomotor disturbances in progressive supranuclear palsy
Por:
Pagonabarraga, J, Horta-Barba, A, Busteed, L, Bejr-Kasem, H, Illan-Gala, I, Aracil-Bolanos, I, Marin-Lahoz, J, Pascual-Sedano, B, Perez, J, Campolongo, A, Izquierdo, C, Martinez-Horta, S, Sampedro, F, Kulisevsky, J
Publicada:
1 abr 2021
Ahead of Print:
1 mar 2021
Resumen:
Objectives: To explore and quantify systematically the ocular abnormal movements present in progressive supranuclear palsy (PSP) from the early stages, to assess the ability of this standardized examination in the differential diagnosis of PSP from Parkinson's disease (PD), and to compare in more detail oculomotor disturbances between PSP variants.
Methods: Sixty-five consecutive PSP patients with <5 years of disease duration diagnosed according to MDS-PSP criteria, 25 PD patients and 25 controls comparable in age, education and disease duration were explored using a bedside battery of tests for the quantitative evaluation of oculomotor dysfunction in clinical practice. Other accepted scales were used for measurement of motor (PSPRS), cognitive (FAB) and behavioral (FBI) impairment.
Results: Measurement of oculomotor dysfunction significantly differentiated PSP from PD and controls (p < 0.001) and showed high accuracy in the differential diagnosis of early-to-mid stage PSP from PD. PSPParkinsonism and PSP-Progressive Gait Freezing phenotypes showed more preserved ocular motor function compared to PSP-Richardson Syndrome, although no differences were found between PSP subtypes in the number of square wave jerks, optokinetic nystagmus defects, degree of apraxia of eyelid opening, or presence of the "Round the Houses" sign.
Conclusions: Using a bedside clinical instrument for quantifying oculomotor disturbances in PSP shows promising potential at differentiating PSP from PD, and it seems able to provide a qualitative and quantitative description of ocular motor function in parkinsonian disorders.
Filiaciones:
Pagonabarraga, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Horta-Barba, A:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Busteed, L:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Bejr-Kasem, H:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Illan-Gala, I:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Hosp Santa Creu & Sant Pau, Neurol Dept, St Pau Memory Unit, Barcelona, Spain
Aracil-Bolanos, I:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Marin-Lahoz, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Pascual-Sedano, B:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Perez, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Campolongo, A:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Izquierdo, C:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Martinez-Horta, S:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Sampedro, F:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Bellaterra, Spain
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