Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity
Por:
Genua, I, Puig, N, Minambres, I, Benitez, S, Gil, P, Grau-Agramunt, M, Rivas-Urbina, A, Balague, C, Fernandez-Alanin, S, Garcia-Osuna, A, Perez, A, Sanchez-Quesada, JL
Publicada:
1 abr 2021
Resumen:
The effect of bariatric surgery on lipid profile and the qualitative characteristics of lipoproteins was analyzed in morbidly obese subjects. Thirteen obese patients underwent bariatric surgery. Plasma samples were obtained before surgery and at 6 and 12 months after the intervention. Thirteen healthy subjects comprised the control group. Lipid profile, hsCRP, and the composition and functional characteristics of VLDL, LDL, and HDL were assessed. At baseline, plasma from subjects with obesity had more triglycerides, VLDLc, and hsCRP, and less HDLc than the control group. These levels progressively normalized after surgery, although triglyceride and hsCRP levels remained higher than those in the controls. The main differences in lipoprotein composition between the obese subjects and the controls were increased apoE in VLDL, and decreased cholesterol and apoJ and increased apoC-III content in HDL. The pro-/anti-atherogenic properties of LDL and HDL were altered in the subjects with obesity at baseline compared with the controls, presenting smaller LDL particles that are more susceptible to modification and smaller HDL particles with decreased antioxidant capacity. Bariatric surgery normalized the composition of lipoproteins and improved the qualitative characteristics of LDL and HDL. In summary, patients with obesity present multiple alterations in the qualitative properties of lipoproteins compared with healthy subjects. Bariatric surgery reverted most of these alterations.
Filiaciones:
Genua, I:
Hosp Santa Creu St & Pau, Endocrinol & Nutr Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra Campus, Barcelona 08041, Spain
Puig, N:
Univ Autonoma Barcelona, Bellaterra Campus, Barcelona 08041, Spain
Hosp Santa Creu & St Pau IIB St Pau, Res Inst, Cardiovasc Biochem Grp, Barcelona 08041, Spain
Minambres, I:
Hosp Santa Creu St & Pau, Endocrinol & Nutr Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra Campus, Barcelona 08041, Spain
Inst Salud Carlos III ISCIII, CIBER Diabet & Metab Dis CIBERDEM, Madrid 28029, Spain
Benitez, S:
Hosp Santa Creu & St Pau IIB St Pau, Res Inst, Cardiovasc Biochem Grp, Barcelona 08041, Spain
Gil, P:
Hosp Santa Creu St & Pau, Endocrinol & Nutr Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra Campus, Barcelona 08041, Spain
Grau-Agramunt, M:
Hosp Santa Creu & St Pau IIB St Pau, Res Inst, Cardiovasc Biochem Grp, Barcelona 08041, Spain
Rivas-Urbina, A:
Univ Autonoma Barcelona, Bellaterra Campus, Barcelona 08041, Spain
Hosp Santa Creu & St Pau IIB St Pau, Res Inst, Cardiovasc Biochem Grp, Barcelona 08041, Spain
Balague, C:
Univ Autonoma Barcelona, Bellaterra Campus, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Metab & Bariatr Surg Unit, Gen & Digest Surg Dept, Barcelona 08041, Spain
Fernandez-Alanin, S:
Hosp Santa Creu & Sant Pau, Metab & Bariatr Surg Unit, Gen & Digest Surg Dept, Barcelona 08041, Spain
Garcia-Osuna, A:
Hosp Santa Creu & St Pau IIB St Pau, Res Inst, Cardiovasc Biochem Grp, Barcelona 08041, Spain
Perez, A:
Hosp Santa Creu St & Pau, Endocrinol & Nutr Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra Campus, Barcelona 08041, Spain
Inst Salud Carlos III ISCIII, CIBER Diabet & Metab Dis CIBERDEM, Madrid 28029, Spain
Sanchez-Quesada, JL:
Hosp Santa Creu & St Pau IIB St Pau, Res Inst, Cardiovasc Biochem Grp, Barcelona 08041, Spain
Inst Salud Carlos III ISCIII, CIBER Diabet & Metab Dis CIBERDEM, Madrid 28029, Spain
Green Published, gold
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