Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study
Por:
Fernandez-Cidon, B, Candas-Estebanez, B, Gil-Serret, M, Amigo, N, Corbella, E, Rodriguez-Sanchez, MA, Padro-Miquel, A, Brotons, C, Hernandez-Mijares, A, Calmarza, P, Jarauta, E, Brea, AJ, Mauri, M, Guijarro, C, Vila, A, Valdivielso, P, Corbella, X, Pinto, X
Publicada:
1 abr 2021
Resumen:
Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.
Filiaciones:
Fernandez-Cidon, B:
Hosp Univ Bellvitge, Lab Clin, Bioquim Especial & Biol Mol, Lhospitalet De Ll 08907, Spain
Candas-Estebanez, B:
Hosp Univ Bellvitge, Lab Clin, Bioquim Especial & Biol Mol, Lhospitalet De Ll 08907, Spain
SCIAS Hosp Barcelona, Clin Lab, Barcelona 08034, Spain
Gil-Serret, M:
Biosfer Teslab, Reus 43204, Spain
Amigo, N:
Biosfer Teslab, Reus 43204, Spain
Univ Rovira & Virgili, CIBERDEM, Tarragona 43002, Spain
Corbella, E:
Hosp Univ Bellvitge IDIBELL, Serv Med Interna, Unidad Lipidos & Riesgo Vasc, Barcelona 08907, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
Rodriguez-Sanchez, MA:
Hosp Univ Bellvitge IDIBELL, Serv Med Interna, Unidad Lipidos & Riesgo Vasc, Barcelona 08907, Spain
Padro-Miquel, A:
Hosp Univ Bellvitge, Lab Clin, Bioquim Especial & Biol Mol, Lhospitalet De Ll 08907, Spain
Brotons, C:
Inst Invest Biomed St Pau, EAP Sardenya, Barcelona 08025, Spain
Hernandez-Mijares, A:
Hosp Univ Dr Peset, Valencia 46017, Spain
Calmarza, P:
Univ Zaragoza, CIBERCV IIS Aragon, Hosp Univ Miguel Servet, Serv Bioquim Clin, Zaragoza 50009, Spain
Jarauta, E:
Univ Zaragoza, CIBERCV IIS Aragon, Hosp Univ Miguel Servet, Serv Bioquim Clin, Zaragoza 50009, Spain
Brea, AJ:
Hosp Gen San Pedro, Logrono 26006, Spain
Mauri, M:
Hosp Terrassa Consorci Sanitari Terrassa, Terrassa 08227, Spain
Guijarro, C:
Univ Rey Juan Carlos, Hosp Univ Fdn Alcorcon, Unidad Med Interna, Dept Esepecialidades Med & Salud Publ, Alcorcon 28922, Spain
Vila, A:
Fundacio Salut Emporda, Hosp Figueres, Figueres 17600, Spain
Valdivielso, P:
Univ Malaga, IBIMA, Hosp Univ Virgen de la Victoria, Malaga 29010, Spain
Corbella, X:
Hosp Univ Bellvitge IDIBELL, Serv Med Interna, Unidad Lipidos & Riesgo Vasc, Barcelona 08907, Spain
Univ Int Catalunya, Fac Med & Ciencias Salud, Barcelona 08017, Spain
Pinto, X:
Hosp Univ Bellvitge IDIBELL, Serv Med Interna, Unidad Lipidos & Riesgo Vasc, Barcelona 08907, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
Univ Barcelona, Dept Med, Campus Bellvitge, Lhospitalet De Ll 08907, Spain
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