Robot-induced hallucinations in Parkinson's disease depend on altered sensorimotor processing in fronto-temporal network
Por:
Bernasconi, F, Blondiaux, E, Potheegadoo, J, Stripeikyte, G, Pagonabarraga, J, Bejr-Kasem, H, Bassolino, M, Akselrod, M, Martinez-Horta, S, Sampedro, F, Hara, M, Horvath, J, Franza, M, Konik, S, Bereau, M, Ghika, JA, Burkhard, PR, Van de Ville, D, Faivre, N, Rognini, G, Krack, P, Kulisevsky, J, Blanke, O
Publicada:
28 abr 2021
Resumen:
Hallucinations in Parkinson's disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the induction of presence hallucinations ( PHs) and the characterization of a subgroup of patients with PD with enhanced sensitivity for conflicting sensorimotor stimulation and robot-induced PH. We next identify the fronto-temporal network of PH by combining MR-compatible robotics (and sensorimotor stimulation in healthy participants) and lesion network mapping (neurological patients without PD). This PH-network was selectively disrupted in an additional and independent cohort of patients with PD, predicted the presence of symptomatic PH, and associated with cognitive decline. These robotics-neuroimaging findings extend existing sensorimotor hallucination models to PD and reveal the pathological cortical sensorimotor processes of PH in PD, potentially indicating a more severe form of PD that has been associated with psychosis and cognitive decline.
Filiaciones:
Bernasconi, F:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Blondiaux, E:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Potheegadoo, J:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Stripeikyte, G:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Pagonabarraga, J:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Barcelona 08193, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid 28031, Spain
Biomed Res Inst IIB St Pau, Barcelona 08041, Spain
Bejr-Kasem, H:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Barcelona 08193, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid 28031, Spain
Biomed Res Inst IIB St Pau, Barcelona 08041, Spain
Bassolino, M:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Akselrod, M:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Lausanne Univ UNIL, MySpace Lab, CH-1011 Lausanne, Switzerland
Univ Hosp Lausanne, CHUV, CH-1011 Lausanne, Switzerland
Martinez-Horta, S:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Barcelona 08193, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid 28031, Spain
Biomed Res Inst IIB St Pau, Barcelona 08041, Spain
Sampedro, F:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Barcelona 08193, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid 28031, Spain
Biomed Res Inst IIB St Pau, Barcelona 08041, Spain
Hara, M:
Saitama Univ, Grad Sch Sci & Engn, Saitama 3388570, Japan
Horvath, J:
Geneva Univ Hosp, Dept Neurol, CH-1205 Geneva, Switzerland
Franza, M:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Konik, S:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Lausanne Univ UNIL, MySpace Lab, CH-1011 Lausanne, Switzerland
Univ Hosp Lausanne, CHUV, CH-1011 Lausanne, Switzerland
Bereau, M:
Geneva Univ Hosp, Dept Neurol, CH-1205 Geneva, Switzerland
Besancon Univ Hosp, Dept Neurol, F-25056 Besancon, France
Ghika, JA:
Hop Valais, Dept Neurol, CH-1951 Sion, Switzerland
Burkhard, PR:
Geneva Univ Hosp, Dept Neurol, CH-1205 Geneva, Switzerland
Van de Ville, D:
Ecole Polytech Fed Lausanne EPFL, Med Image Proc Lab, Inst Bioengn, CH-1202 Geneva, Switzerland
Univ Geneva, Dept Radiol & Med Informat, CH-1206 Geneva, Switzerland
Faivre, N:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Univ Grenoble Alpes, Univ Savoie Mt Blanc, LPNC, CNRS, F-38000 Grenoble, France
Rognini, G:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Krack, P:
Univ Hosp, Dept Neurol, Inselspital, CH-3010 Bern, Switzerland
Univ Bern, CH-3010 Bern, Switzerland
Kulisevsky, J:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Barcelona 08193, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid 28031, Spain
Biomed Res Inst IIB St Pau, Barcelona 08041, Spain
Blanke, O:
Ecole Polytech Fed Lausanne EPFL, Lab Cognit Neurosci, Ctr Neuroprosthet & Brain Mind Inst, CH-1202 Geneva, Switzerland
Geneva Univ Hosp, Dept Neurol, CH-1205 Geneva, Switzerland
Green Submitted
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