International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery
Por:
Lindgren, AG, Braun, RG, Majersik, JJ, Clatworthy, P, Mainali, S, Derdeyn, CP, Maguire, J, Jern, C, Rosand, J, Cole, JW, Lee, JM, Khatri, P, Nyquist, P, Debette, S, Wei, LK, Rundek, T, Leifer, D, Thijs, V, Lemmens, R, Heitsch, L, Prasad, K, Conde, JJ, Dichgans, M, Rost, NS, Cramer, SC, Bernhardt, J, Worrall, BB, Fernandez-Cadenas, I
Publicada:
1 mar 2022
Ahead of Print:
1 abr 2021
Resumen:
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.
Filiaciones:
Lindgren, AG:
Lund Univ, Dept Clin Sci Lund, Neurol, Lund, Sweden
Skane Univ Hosp, Dept Neurol, SE-22185 Lund, Sweden
Braun, RG:
Univ Maryland, Dept Neurol, Baltimore, MD 21201 USA
Majersik, JJ:
Univ Utah, Dept Neurol, Salt Lake City, UT USA
Clatworthy, P:
North Bristol NHS Trust, Dept Neurol, Bristol, Avon, England
Mainali, S:
Ohio State Univ, Dept Neurol, Columbus, OH 43210 USA
Derdeyn, CP:
Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA
Maguire, J:
Univ Technol Sydney, Fac Hlth, Ultimo, NSW, Australia
Jern, C:
Univ Gothenburg, Inst Biomed, Dept Lab Med, Gothenburg, Sweden
Sahlgrens Univ Hosp, Dept Clin Genet & Genom, Gothenburg, Sweden
Rosand, J:
Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
Cole, JW:
Baltimore Vet Affairs Med Ctr, Neurol Serv, Baltimore, MD USA
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
Lee, JM:
Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
Khatri, P:
Univ Cincinnati, Dept Neurol & Rehabil Sci, Cincinnati, OH USA
Nyquist, P:
Johns Hopkins Sch Med, Neurol Anesthesiol Crit Care Med Neurosurg & Gen, Baltimore, MD USA
Debette, S:
Univ Bordeaux, Bordeaux Populat Hlth, INSERM, U1219, Bordeaux, France
Bordeaux Univ Hosp, Neurol Dept, Bordeaux, France
Wei, LK:
Univ Tunku Abdul Rahman, Fac Sci, Dept Biol Sci, Kampar, Perak, Malaysia
Rundek, T:
Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA
Leifer, D:
Weill Cornell Med, Dept Neurol, New York, NY USA
Thijs, V:
Florey Inst Neurosci & Mental Hlth, Stroke Theme, Melbourne, Vic, Australia
Lemmens, R:
Univ Leuven, Dept Neurosci, Leuven, Belgium
Univ Hosp Leuven, Dept Neurol, Leuven, Belgium
Heitsch, L:
Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
Prasad, K:
Rajendra Inst Med Sci, Ranchi, Jharkhand, India
Conde, JJ:
Inst Hosp Mar Invest Med, Neurovasc Res Grp, Neurol Dept, Barcelona, Spain
Univ Autonoma Barcelona, Neurol, Barcelona, Spain
Dichgans, M:
LMU, Univ Hosp, Inst Stroke & Dementia Res, Munich, Germany
Rost, NS:
Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
Cramer, SC:
Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA
Calif Rehabil Inst, Los Angeles, CA USA
Bernhardt, J:
Florey Inst Neurosci & Mental Hlth, Stroke Theme, Melbourne, Vic, Australia
LMU, Univ Hosp, Inst Stroke & Dementia Res, Munich, Germany
Worrall, BB:
Univ Virginia, Dept Neurol, Charlottesville, VA USA
Fernandez-Cadenas, I:
St Pau Biomed Res Inst, Stroke Pharmacogen & Genet Grp, Barcelona, Spain
Green Submitted, Green Published, hybrid, All Open Access, Hybrid Gold, Green
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