Food groups associated with immune-mediated inflammatory diseases: a Mendelian randomization and disease severity study
Por:
Julia, A, Martinez-Mateu, SH, Domenech, E, Canete, JD, Ferrandiz, C, Tornero, J, Gisbert, JP, Fernandez-Nebro, A, Dauden, E, Barreiro-de Acosta, M, Perez, C, Queiro, R, Lopez-Longo, FJ, Carazo, JLS, Mendoza, JL, Alperi, M, Montilla, C, Venegas, JJP, Munoz, F, Castaneda, S, Lasanta, ML, Marsal, S, Fonseca, E, Rodriguez, J, Carreira, P, Garcia, V, Pinto-Tasende, JA, Puig, L, Ricart, E, Blanco, F, Gratacos, J, Blanco, R, Taboada, VM, Fernandez, E, Unamuno, P, Gonzalez, I, Garcia, FG, Sanmarti, R, Gutierrez, A, Olive, A, Estebaranz, JLL, Garcia-Planella, E, Torre-Alonso, JC, Andreu, JL, Ramirez, DM, Fernandez, B, Zamorano, MAA, de la Cueva, P, Mateu, PN, Vela, P, Vanaclocha, F, Coromines, H, Munoz, S, Nolla, JM, Herrera, E, Gonzalez, C, de la Fuente, JLM, Vera, M, Erra, A, Roig, D, Zea, A, Comas, ME, Tomas, C, Zarco, P, Pego, JM, Saro, C, Gonzalez, A, Freire, M, Garcia, A, Diez, E, Salvador, G, Diaz, C, Sanchez, S, Dominguez, AW, Mosquera, JA, Ramirez, J, Almaraz, ER, Palau, N, Tortosa, R, Lopez, M, Pluma, A, Aterido, A
Publicada:
1 sep 2021
Ahead of Print:
1 abr 2021
Resumen:
Background/Objectives Immune-mediated inflammatory diseases (IMIDs) are prevalent diseases. There is, however, a lack of understanding of the link between diet and IMIDs, how much dietary patterns vary between them and if there are food groups associated with a worsening of the disease. Subjects/Methods To answer these questions we analyzed a nation-wide cohort of n = 11,308 patients from six prevalent IMIDs and 2050 healthy controls. We compared their weekly intake of the major food categories, and used a Mendelian randomization approach to determine which dietary changes are caused by disease. Within each IMID, we analyzed the association between food frequency and disease severity. Results After quality control, n = 11,230 recruited individuals were used in this study. We found that diet is profoundly altered in all IMIDs: at least three food categories are significantly altered in each disease (P < 0.05). Inflammatory bowel diseases showed the largest differences compared to controls (n >= 8 categories, P < 0.05). Mendelian randomization analysis supported that some of these dietary changes, like vegetable reduction in Crohn's Disease (P = 2.5 x 10(-10), OR(95% CI) = 0.73(0.65, 0.80)), are caused by the disease. Except for Psoriatic Arthritis and Systemic Lupus Erythematosus, we have found >= 2 food groups significantly associated with disease severity in the other IMIDs (P < 0.05). Conclusions This cross-disease study demonstrates that prevalent IMIDs are associated to a significant change in the normal dietary patterns. This variation is highly disease-specific and, in some cases, it is caused by the disease itself. Severity in IMIDs is also associated with specific food groups. The results of this study underscore the importance of studying diet in IMIDs.
Filiaciones:
Julia, A:
Vall dHebron Hosp Res Inst, Rheumatol Res Grp, Barcelona, Spain
Martinez-Mateu, SH:
Vall dHebron Hosp Res Inst, Rheumatol Res Grp, Barcelona, Spain
Domenech, E:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
CIBEREHD, Madrid, Spain
Canete, JD:
Hosp Clin Barcelona, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Ferrandiz, C:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Tornero, J:
Hosp Univ Guadalajara, Guadalajara, Spain
Gisbert, JP:
CIBEREHD, Madrid, Spain
Hosp Univ Princesa & IIS IP, Madrid, Spain
Fernandez-Nebro, A:
Univ Malaga, Hosp Reg Univ Malaga, Inst Invest Biomed IBIMA, UGC Reumatol, Malaga, Spain
Dauden, E:
Hosp Univ Princesa & IIS IP, Madrid, Spain
Barreiro-de Acosta, M:
Hosp Clin Univ Santiago, Santiago De Compostela, Spain
Perez, C:
Hosp Mar, Barcelona, Spain
Queiro, R:
Hosp Univ Cent Asturias, Oviedo, Spain
Lopez-Longo, FJ:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Carazo, JLS:
Consorcio Hosp Gen Univ Valencia, Valencia, Spain
Mendoza, JL:
Hosp Clin San Carlos, Madrid, Spain
Alperi, M:
Hosp Univ Cent Asturias, Oviedo, Spain
Montilla, C:
Hosp Virgen Vega, Salamanca, Spain
Venegas, JJP:
Hosp Univ Virgen Macarena, Seville, Spain
Munoz, F:
Complejo Asistencial Univ Leon, Leon, Spain
Castaneda, S:
Hosp Univ Princesa & IIS IP, Madrid, Spain
Lasanta, ML:
Vall dHebron Hosp Res Inst, Rheumatol Res Grp, Barcelona, Spain
Marsal, S:
Vall dHebron Hosp Res Inst, Rheumatol Res Grp, Barcelona, Spain
Fonseca, E:
Complejo Hosp Univ A Coruna, Dermatol Dept, La Coruna, Spain
Rodriguez, J:
Hosp Univ Bellvitge, Rheumatol Dept, Barcelona, Spain
Carreira, P:
Hosp Univ 12 Octubre, Rheumatol Dept, Madrid, Spain
Garcia, V:
Hosp Univ Reina Sofia, Gastroenterol Dept, Cordoba, Spain
Pinto-Tasende, JA:
Complejo Hosp Univ A Coruna, Rheumatol Dept, La Coruna, Spain
Puig, L:
Hosp Santa Creu & Sant Pau, Dermatol Dept, Barcelona, Spain
Ricart, E:
Fundacio Clin Recerca Biomed, Gastroenterol Dept, Barcelona, Spain
Blanco, F:
Complejo Hosp Univ Coruna, Rheumatol Dept, La Coruna, Spain
Gratacos, J:
Hosp Univ Parc Tauli, Rheumatol Dept, Sabadell, Spain
Blanco, R:
Hosp Univ Marques Valdecilla, Rheumatol Dept, Santander, Spain
Taboada, VM:
Hosp Univ Marques Valdecilla, Rheumatol Dept, Santander, Spain
Fernandez, E:
Hosp Univ Salamanca, Dermatol Dept, Salamanca, Spain
Unamuno, P:
Hosp Univ Salamanca, Dermatol Dept, Salamanca, Spain
Gonzalez, I:
Hosp Univ La Princesa, Rheumatol Dept, Madrid, Spain
Garcia, FG:
Hosp Clin Univ Lozano Blesa, Gastroenterol Dept, Zaragoza, Spain
Sanmarti, R:
Fundacio Clin Recerca Biomed, Rheumatol Dept, Barcelona, Spain
Gutierrez, A:
Hosp Gen Univ Alicante, Gastroenterol Dept, Alicante, Spain
Olive, A:
Hosp Badalona Germans Trias & Pujol, Rheumatol Dept, Badalona, Spain
Estebaranz, JLL:
Hosp Univ Fdn Alcorcon, Dermatol Dept, Madrid, Spain
Garcia-Planella, E:
Hosp Santa Creu & Sant Pau, Gastroenterol Dept, Barcelona, Spain
Torre-Alonso, JC:
Hosp Monte Naranco, Rheumatol Dept, Oviedo, Spain
Andreu, JL:
Hosp Univ Puerta Hierro, Rheumatol Dept, Madrid, Spain
Ramirez, DM:
Hosp Univ Virgen Macarena, Dermatol Dept, Seville, Spain
Fernandez, B:
Hosp Clin San Carlos, Rheumatol Dept, Madrid, Spain
Zamorano, MAA:
Hosp Univ Reina Sofia, Rheumatol Dept, Cordoba, Spain
de la Cueva, P:
Hosp Univ Infanta Leonor, Dermatol Dept, Madrid, Spain
Mateu, PN:
Hosp Clin Politecn, Gastroenterol Dept, Valencia, Spain
Vela, P:
Hosp Gen Univ Alicante, Rheumatol Dept, Alicante, Spain
Vanaclocha, F:
Hosp Univ 12 Octubre, Dermatol Dept, Madrid, Spain
Coromines, H:
Hosp Santa Creu & Sant Pau, Rheumatol Dept, Barcelona, Spain
Munoz, S:
Hosp Univ Infanta Sofia, Rheumatol Dept, Madrid, Spain
Nolla, JM:
Hosp Univ Bellvitge, Rheumatol Dept, Barcelona, Spain
Herrera, E:
Hosp Univ Virgen Victoria, Dermatol Dept, Malaga, Spain
Gonzalez, C:
Hosp Gen Univ Gregorio Maranon, Rheumatol Dept, Madrid, Spain
de la Fuente, JLM:
Hosp Univ Virgen Valme, Rheumatol Dept, Seville, Spain
Vera, M:
Hosp Univ Puerta Hierro, Gastroenterol Dept, Madrid, Spain
Erra, A:
Hosp Univ Vall Hebron, Rheumatol Dept, Barcelona, Spain
Roig, D:
Ctr Atencio Especialitzada Cornella Llobregat, Rheumatol Dept, Barcelona, Spain
Zea, A:
Hosp Univ Ramon & Cajal, Rheumatol Dept, Madrid, Spain
Comas, ME:
Hosp Univ MutuaTerrassa, Gastroenterol Dept, Barcelona, Spain
Tomas, C:
Hosp Comarcal d'Amposta, Rheumatol Dept, Amposta, Spain
Zarco, P:
Hosp Univ Fdn Alcorcon, Rheumatol Dept, Madrid, Spain
Pego, JM:
Hosp Meixoeiro, Rheumatol Dept, Vigo, Spain
Saro, C:
Hosp Univ Cabuenes, Internal Med Dept, Gijon, Spain
Gonzalez, A:
Hosp Clin Univ Santiago, Rheumatol Dept, Santiago De Compostela, Spain
Freire, M:
Complejo Hosp Univ Coruna, Rheumatol Dept, La Coruna, Spain
Garcia, A:
Ctr Perifer Especialidades Virgen Reyes, Rheumatol Dept, Seville, Spain
Diez, E:
Complejo Asistencial Univ Leon, Rheumatol Dept, Leon, Spain
Salvador, G:
Hosp Univ MutuaTerrassa, Rheumatol Dept, Terrassa, Spain
Diaz, C:
Hosp Santa Creu & Sant Pau, Rheumatol Dept, Barcelona, Spain
Sanchez, S:
Hosp Gen Mancha Centro, Rheumatol Dept, Ciudad Real, Spain
Dominguez, AW:
Complexo Hosp Univ Ourense, Rheumatol Dept, Orense, Spain
Mosquera, JA:
Complejo Hosp Univ Pontevedra, Rheumatol Dept, Pontevedra, Spain
Ramirez, J:
Hosp Clin Barcelona, Rheumatol Dept, Barcelona, Spain
Almaraz, ER:
Hosp Univ 12 Octubre, Rheumatol Dept, Madrid, Spain
Palau, N:
Hosp Univ Vall Hebron, Rheumatol Dept, Barcelona, Spain
Tortosa, R:
Hosp Univ Vall Hebron, Rheumatol Dept, Barcelona, Spain
Lopez, M:
Hosp Univ Vall Hebron, Rheumatol Dept, Barcelona, Spain
Pluma, A:
Hosp Univ Vall Hebron, Rheumatol Dept, Barcelona, Spain
Aterido, A:
Vall dHebron Hosp Res Inst, Rheumatol Res Grp, Barcelona, Spain
Hosp Univ Vall Hebron, Rheumatol Dept, Barcelona, Spain
|