Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey
Por:
Fine, SW, Trpkov, K, Amin, MB, Algaba, F, Aron, M, Baydar, DE, Beltran, AL, Brimo, F, Cheville, JC, Colecchia, M, Comperat, E, Costello, T, da Cunha, IW, Delprado, W, DeMarzo, AM, Giannico, GA, Gordetsky, JB, Guo, CC, Hansel, DE, Hirsch, MS, Huang, JT, Humphrey, PA, Jimenez, RE, Khani, F, Kong, MX, Kryvenko, ON, Kunju, LP, Lal, P, Latour, M, Lotan, T, Maclean, F, Magi-Galluzzi, C, Mehra, R, Menon, S, Miyamoto, H, Montironi, R, Netto, GJ, Nguyen, JK, Osunkoya, AO, Parwani, A, Pavlovich, CP, Robinson, BD, Rubin, MA, Shah, RB, So, JS, Takahashi, H, Tavora, F, Tretiakova, MS, True, L, Wobker, SE, Yang, XMJ, Zhou, M, Zynger, DL, Epstein, JI
Publicada:
1 may 2021
Ahead of Print:
1 may 2021
Resumen:
Purpose: To survey urologic clinicians regarding interpretation of and practice patterns in relation to emerging aspects of prostate cancer grading, including quantification of high-grade disease, cribriform/intraductal carcinoma, and impact of magnetic resonance imaging-targeted needle biopsy.
Materials and methods: The Genitourinary Pathology Society distributed a survey to urology and urologic oncology-focused societies and hospital departments. Eight hundred and thirty four responses were collected and analyzed using descriptive statistics.
Results: Eighty percent of survey participants use quantity of Gleason pattern 4 on needle biopsy for clinical decisions, less frequently with higher Grade Groups. Fifty percent interpret "tertiary" grade as a minor/< 5% component. Seventy percent of respondents would prefer per core grading as well as a global/overall score per set of biopsies, but 70% would consider highest Gleason score in any single core as the grade for management. Seventy five percent utilize Grade Group terminology in patient discussions. For 45%, cribriform pattern would affect management, while for 70% the presence of intraductal carcinoma would preclude active surveillance.
Conclusion: This survey of practice patterns in relationship to prostate cancer grading highlights similarities and differences between contemporary pathology reporting and its clinical application. As utilization of Gleason pattern 4 quantification, minor tertiary pattern, cribriform/intraductal carcinoma, and the incorporation of magnetic resonance imaging-based strategies evolve, these findings may serve as a basis for more nuanced communication and guide research efforts involving pathologists and clinicians. (C) 2020 Elsevier Inc. All rights reserved.
Filiaciones:
Fine, SW:
Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA
Trpkov, K:
Univ Calgary, Dept Pathol & Lab Med, Calgary, AB, Canada
Alberta Precis Labs, Calgary, AB, Canada
Amin, MB:
Univ Tennessee Hlth Sci, Dept Pathol & Lab Med & Urol, Memphis, TN USA
Algaba, F:
Fundacio Puigvert, Dept Pathol, Barcelona, Spain
Aron, M:
Univ Southern Calif, Dept Pathol, Los Angeles, CA 90007 USA
Baydar, DE:
Koc Univ, Fac Med, Dept Pathol, Istanbul, Turkey
Beltran, AL:
Champalimaud Ctr Unknown, Dept Pathol, Lisbon, Portugal
Brimo, F:
McGill Univ Hlth Ctr, Dept Pathol, Montreal, PQ, Canada
Cheville, JC:
Mayo Clin, Dept Pathol, Rochester, MN USA
Colecchia, M:
Fdn IRCCS Ist Nazl Tumori, Dept Pathol & Lab Med, Milan, Italy
Comperat, E:
Sorbonne Univ, Dept Pathol, Hop Tenon, Paris, France
Costello, T:
Royal Melbourne Hosp, Dept Urol, Melbourne, Vic, Australia
da Cunha, IW:
Rede DOR Sao Luiz Sao Paulo, Pathol Dept, Sao Paulo, SP, Brazil
Delprado, W:
Douglass Hanly Moir Pathol, Sydney, NSW, Australia
DeMarzo, AM:
Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
Giannico, GA:
Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Nashville, TN USA
Gordetsky, JB:
Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Nashville, TN USA
Guo, CC:
Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
Hansel, DE:
Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA
Hirsch, MS:
Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
Huang, JT:
Duke Univ, Sch Med, Dept Pathol, Durham, NC 27706 USA
Humphrey, PA:
Yale Sch Med, Dept Pathol, New Haven, CT USA
Jimenez, RE:
Mayo Clin, Dept Pathol, Rochester, MN USA
Khani, F:
Weill Cornell Med, Dept Pathol & Lab Med, New York, NY USA
Weill Cornell Med, Dept Urol, New York, NY USA
Kong, MX:
Kaiser Permanente Sacramento Med Ctr, Dept Pathol, Sacramento, CA USA
Kryvenko, ON:
Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33136 USA
Univ Miami, Miller Sch Med, Dept Lab Med, Miami, FL 33136 USA
Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
Kunju, LP:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA
Lal, P:
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
Latour, M:
Univ Montreal, Dept Pathol, CHUM, Montreal, PQ, Canada
Lotan, T:
Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
Maclean, F:
Douglass Hanly Moir Pathol, Sydney, NSW, Australia
Magi-Galluzzi, C:
Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA
Mehra, R:
Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA
Menon, S:
Tata Mem Hosp, Dept Surg Pathol, Mumbai, Maharashtra, India
Miyamoto, H:
Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Urol, Rochester, NY 14642 USA
Montironi, R:
Polytech Univ Marche Reg, United Hosp, Sch Med, Sect Pathol Anat, Ancona, Italy
Netto, GJ:
Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA
Nguyen, JK:
Cleveland Clin, Robert J Tomsich Pathol & Lab Med Inst, Cleveland, OH 44106 USA
Osunkoya, AO:
Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA
Parwani, A:
Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
Pavlovich, CP:
Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA
Robinson, BD:
Weill Cornell Med, Dept Pathol & Lab Med, New York, NY USA
Weill Cornell Med, Dept Urol, New York, NY USA
Rubin, MA:
Univ Bern, Dept BioMed Res, Bern, Switzerland
Shah, RB:
Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX USA
So, JS:
St Lukes Med Ctr, Inst Pathol, Quezon City, Philippines
St Lukes Med Ctr, Inst Pathol, Global City, Philippines
Takahashi, H:
Jikei Univ, Dept Pathol, Sch Med, Tokyo, Japan
Tavora, F:
Univ Fed Ceara, Argos Lab, Fortaleza, Ceara, Brazil
Tretiakova, MS:
Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA
True, L:
Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA
Wobker, SE:
Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA
Univ N Carolina, Dept Urol, Chapel Hill, NC USA
Yang, XMJ:
Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA
Zhou, M:
Tufts Med Ctr, Dept Pathol, Boston, MA 02111 USA
Zynger, DL:
Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
Epstein, JI:
Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA
Open Access
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