Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging
Por:
Kim, CM, Montal, V, Diez, I, Orwig, W, Sepulcre, J, Alzheimer's Dis Neuroimaging
Publicada:
1 jul 2021
Ahead of Print:
1 may 2021
Resumen:
Amyloid-beta (A beta) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to A beta and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined graph theory-based positron emission tomography (PET) analytical approaches, within and between tau and A beta PET modalities, and tested the effects on cognitive changes in cognitively normal older adults (CN). Particularly, we focused on the network interdigitations of A beta and tau deposits, along with cognitive test scores in CN at both baseline and 2-year follow-up (FU). We found highly significant A beta-tau network integrations in AD vulnerable areas, as well as significant associations between those A beta-tau interdigitations and general cognitive impairment in CN at baseline and FU. Our findings suggest a distinctive contribution of interlinking network relationships between A beta and tau deposits in heteromodal areas of the human brain. They support a network-based interaction between A beta and tau accumulations as a key factor for cognitive deterioration in CN prior to dementia.
Filiaciones:
Kim, CM:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Gordon Ctr Med Imaging, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Montal, V:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Gordon Ctr Med Imaging, Boston, MA 02115 USA
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Diez, I:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Gordon Ctr Med Imaging, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Orwig, W:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Gordon Ctr Med Imaging, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Sepulcre, J:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Gordon Ctr Med Imaging, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
gold, Green Published
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