Sarilumab (IL-6R antagonist) in critically ill patients with cytokine release syndrome by SARS-CoV2


Por: Corominas, H, Castellvi, I, Diaz-Torne, C, Matas, L, de la Rosa, D, Mangues, MA, Moya, P, Pomar, V, Benito, N, Moga, E, Hernandez-de Sosa, N, Casademont, J, Domingo, P

Publicada: 14 may 2021
Resumen:
Blocking IL-6 pathways with sarilumab, a fully human anti-IL-6R antagonist may potentially curb the inflammatory storm of SARS-CoV2. In the present emergency scenario, we used "off-label" sarilumab in 5 elderly patients in life-threatening condition not candidates to further active measures. We suggest that sarilumab can modulate severe COVID-19-associated Cytokine Release Syndrome.

Filiaciones:
Corominas, H:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Reumatol, Barcelona, Catalonia, Spain

Castellvi, I:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Reumatol, Barcelona, Catalonia, Spain

Diaz-Torne, C:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Reumatol, Barcelona, Catalonia, Spain

Matas, L:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Med Interna, Barcelona, Catalonia, Spain

de la Rosa, D:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Pneumol, Barcelona, Catalonia, Spain

Mangues, MA:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Farm Hosp, Barcelona, Catalonia, Spain

Moya, P:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Reumatol, Barcelona, Catalonia, Spain

Pomar, V:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Unitat Malalties Infeccioses, Barcelona, Catalonia, Spain

Benito, N:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Unitat Malalties Infeccioses, Barcelona, Catalonia, Spain

Moga, E:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Immunol, Barcelona, Catalonia, Spain

Hernandez-de Sosa, N:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Med Interna, Barcelona, Catalonia, Spain

Casademont, J:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Serv Med Interna, Barcelona, Catalonia, Spain

Domingo, P:
 Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Unitat Malalties Infeccioses, Barcelona, Catalonia, Spain
ISSN: 00257974





MEDICINE
Editorial
LIPPINCOTT WILLIAMS & WILKINS, TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 100 Número: 19
Páginas:
WOS Id: 000658910800078
ID de PubMed: 34106658
imagen Green Published, gold

MÉTRICAS