NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
Por:
Delaby, C, Julian, A, Page, G, Ragot, S, Lehmann, S, Paccalin, M
Publicada:
13 may 2021
Resumen:
Peripheral inflammation mechanisms involved in Alzheimer's disease (AD) have yet to be accurately characterized and the identification of blood biomarker profiles could help predict cognitive decline and optimize patient care. Blood biomarkers described to date have failed to provide a consensus signature, which is mainly due to the heterogeneity of the methods used or the cohort. The present work aims to describe the potential informativity of peripheral inflammation in AD, focusing in particular on the potential association between the level of plasma neurofilament light (NFL), peripheral inflammation (by quantifying IL-1 beta, IL-6, TNF alpha, CCL5, TNF-R1, sIL-6R, TIMP-1, IL-8 in blood) and cognitive decline (assessed by the MMSE and ADAScog scales) through a 2-year follow-up of 40 AD patients from the Cytocogma cohort (CHU Poitiers, Pr M. Paccalin). Our results show for the first time a strong correlation between plasma NFL and TNF-R1 at each time of follow-up (baseline, 12 and 24 months), thus opening an interesting perspective for the prognosis of AD patients.
Filiaciones:
Delaby, C:
Univ Montpellier, CHU Montpellier, INSERM, Lab Biochim Proteom,INM,IRMB, Montpellier, France
Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Julian, A:
Univ Poitiers, EA3808 NEUVACOD Neurovasc Unit, Poitiers, France
Univ Poitiers, Cognit Disorders, Poitiers, France
Univ Poitiers Hosp, Memory Ctr Resources, Poitiers, France
Univ Poitiers Hosp, Memory Ctr Res, Poitiers, France
Univ Poitiers Hosp, Ctr Invest Clin CIC1402, INSERM, Poitiers, France
Page, G:
Univ Poitiers, EA3808 NEUVACOD Neurovasc Unit, Poitiers, France
Univ Poitiers, Cognit Disorders, Poitiers, France
Ragot, S:
Univ Poitiers Hosp, Ctr Invest Clin CIC1402, INSERM, Poitiers, France
Lehmann, S:
Univ Montpellier, CHU Montpellier, INSERM, Lab Biochim Proteom,INM,IRMB, Montpellier, France
Paccalin, M:
Univ Poitiers, EA3808 NEUVACOD Neurovasc Unit, Poitiers, France
Univ Poitiers, Cognit Disorders, Poitiers, France
Univ Poitiers Hosp, Memory Ctr Resources, Poitiers, France
Univ Poitiers Hosp, Memory Ctr Res, Poitiers, France
Univ Poitiers Hosp, Ctr Invest Clin CIC1402, INSERM, Poitiers, France
gold, Green Published, All Open Access, Gold, Green
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