Gray Matter Vulnerabilities Predict Longitudinal Development of Apathy in Huntington's Disease
Por:
De Paepe, AE, Ara, A, Garcia-Gorro, C, Martinez-Horta, S, Perez-Perez, J, Kulisevsky, J, Rodriguez-Dechicha, N, Vaquer, I, Subira, S, Calopa, M, Munoz, E, Santacruz, P, Ruiz-Idiago, J, Mareca, C, de Diego-Balaguer, R, Camara, E
Publicada:
1 sep 2021
Ahead of Print:
1 may 2021
Resumen:
Background Apathy, a common neuropsychiatric disturbance in Huntington's disease (HD), is subserved by a complex neurobiological network. However, no study has yet employed a whole-brain approach to examine underlying regional vulnerabilities that may precipitate apathy changes over time.
Objectives To identify whole-brain gray matter volume (GMV) vulnerabilities that may predict longitudinal apathy development in HD.
Methods Forty-five HD individuals (31 female) were scanned and evaluated for apathy and other neuropsychiatric features using the short-Problem Behavior Assessment for a maximum total of six longitudinal visits (including baseline). In order to identify regions where changes in GMV may describe changes in apathy, we performed longitudinal voxel-based morphometry (VBM) on those 33 participants with a magnetic resonance imaging (MRI) scan on their second visit at 18 +/- 6 months follow-up (78 MRI datasets). We next employed a generalized linear mixed-effects model (N = 45) to elucidate whether initial and specific GMV may predict apathy development over time.
Results Utilizing longitudinal VBM, we revealed a relationship between increases in apathy and specific GMV atrophy in the right middle cingulate cortex (MCC). Furthermore, vulnerability in the right MCC volume at baseline successfully predicted the severity and progression of apathy over time.
Conclusions This study highlights that individual differences in apathy in HD may be explained by variability in atrophy and initial vulnerabilities in the right MCC, a region implicated in action-initiation. These findings thus serve to facilitate the prediction of an apathetic profile, permitting targeted, time-sensitive interventions in neurodegenerative disease with potential implications in otherwise healthy populations. (c) 2021 International Parkinson and Movement Disorder Society
Filiaciones:
De Paepe, AE:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Ara, A:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Barcelona, Spain
Garcia-Gorro, C:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Martinez-Horta, S:
European Huntingtons Dis Network, Ulm, Germany
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Dept Neurol, Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Carlos III Inst, CIBERNED Ctr Networked Biomed Res Neurodegenerat, Madrid, Spain
Perez-Perez, J:
European Huntingtons Dis Network, Ulm, Germany
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Dept Neurol, Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Carlos III Inst, CIBERNED Ctr Networked Biomed Res Neurodegenerat, Madrid, Spain
Kulisevsky, J:
European Huntingtons Dis Network, Ulm, Germany
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Dept Neurol, Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Carlos III Inst, CIBERNED Ctr Networked Biomed Res Neurodegenerat, Madrid, Spain
Rodriguez-Dechicha, N:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Vaquer, I:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Subira, S:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Univ Autonoma Barcelona, Dept Psicol Clin & Salut, Barcelona, Spain
Calopa, M:
Hosp Univ Bellvitge, Neurol Serv, Movement Disorders Unit, Barcelona, Spain
Munoz, E:
European Huntingtons Dis Network, Ulm, Germany
Hosp Clin Barcelona, Neurol Serv, Movement Disorders Unit, Barcelona, Spain
IDIBAPS Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Univ Barcelona, Fac Med, Barcelona, Spain
Santacruz, P:
Hosp Clin Barcelona, Neurol Serv, Movement Disorders Unit, Barcelona, Spain
Ruiz-Idiago, J:
Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Barcelona, Spain
Hosp Mare de Deu de la Merce, Barcelona, Spain
Mareca, C:
Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Barcelona, Spain
de Diego-Balaguer, R:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Barcelona, Spain
European Huntingtons Dis Network, Ulm, Germany
ICREA Catalan Inst Res & Adv Studies, Barcelona, Spain
Camara, E:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
European Huntingtons Dis Network, Ulm, Germany
Green Accepted
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