Registered trials address questions already answered with high-certainty evidence: A sample of current redundant research
Por:
Vergara-Merino, L, Verdejo, C, Franco, JVA, Liquitay, CE, Urrutia, G, Klabunde, R, Perez, P, Sanchez, L, Madrid, E
Publicada:
1 jun 2021
Ahead of Print:
1 mar 2021
Resumen:
Objective: To identify clinical trials registered later than 2015, that study the effect of an intervention on a primary outcome whose "Certainty of Evidence" (CoE) has already been rated "high" in a Cochrane SR.
Study Design and Setting: We searched the Cochrane Library for all SRs from 2015. We analyzed SRs of interventions and excluded withdrawn reviews or those with no Summary of Findings (SoF) table. We retrieved the GRADE CoE ratings of each SR's primary outcomes in the SoF tables and identified those rated "high." We searched the World Health Organization International Clinical Trials Registry Platform and ClinicalTrials to identify records of clinical studies that tackled those outcomes and were registered after the date of publication of the respective 2015 SR.
Results: We selected 602 SRs. Eighty-one contained a "high" CoE rating on at least one primary outcome, totaling 152 primary outcomes rated "high." We found 39 clinical trials registered for primary outcomes with evidence already rated as "high" in a 2015 Cochrane SR.
Conclusion: This study shows the existence of clinical trials registered to study primary outcomes whose CoE has already been rated "high" in a Cochrane SR. (c) 2021 Elsevier Inc. All rights reserved.
Filiaciones:
Vergara-Merino, L:
Univ Valparaiso, Associate Ctr, Cochrane Chile, Angamos 655,Room 1111, Vina Del Mar, Chile
Univ Valparaiso, Interdisciplinary Ctr Hlth Studies CIESAL, Vina Del Mar, Chile
Univ Valparaiso, Sch Med, Angamos 655, Vina Del Mar, Chile
Verdejo, C:
Univ Valparaiso, Sch Med, Angamos 655, Vina Del Mar, Chile
Franco, JVA:
Inst Univ Hosp Italiano, Biblioteca Cent, Ctr Cochrane Asociado, Potosi 4265,C1199, Buenos Aires, DF, Argentina
Liquitay, CE:
Inst Univ Hosp Italiano, Biblioteca Cent, Ctr Cochrane Asociado, Potosi 4265,C1199, Buenos Aires, DF, Argentina
Urrutia, G:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, CIBERESP, Ctr Cochrane Iberoamer, 167 Pavello 18,Planta 0, Barcelona 08025, Spain
Klabunde, R:
Univ Valparaiso, Associate Ctr, Cochrane Chile, Angamos 655,Room 1111, Vina Del Mar, Chile
Perez, P:
Univ Valparaiso, Associate Ctr, Cochrane Chile, Angamos 655,Room 1111, Vina Del Mar, Chile
Univ Valparaiso, Sch Med, Angamos 655, Vina Del Mar, Chile
Sanchez, L:
Univ Valparaiso, Sch Med, Angamos 655, Vina Del Mar, Chile
Madrid, E:
Univ Valparaiso, Associate Ctr, Cochrane Chile, Angamos 655,Room 1111, Vina Del Mar, Chile
Univ Valparaiso, Interdisciplinary Ctr Hlth Studies CIESAL, Vina Del Mar, Chile
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