Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia
Por:
Escola-Gil, JC, Rotllan, N, Julve, J, Blanco-Vaca, F
Publicada:
1 jun 2021
Resumen:
Purpose of Review We seek to establish whether high-density lipoprotein HDL metabolism and reverse cholesterol transport (RCT) impairment is an intrinsic feature of familial hypercholesterolemia (FH). Recent Findings RCT from macrophages (m-RCT), a vascular cell type of major influence on atherosclerosis, is impaired in FH due to defective low-density lipoprotein receptor (LDLR) function via both the HDL- and LDL-mediated pathways. Potential mechanisms include impaired HDL metabolism, which is linked to increased LDL levels, as well as the increased transport of cellular unesterified cholesterol to LDL, which presents a defective catabolism. RCT dysfunction is consistently associated with mutation-positive FH linked to decreased HDL levels as well as impaired HDL remodeling and LDLR function. It remains to be explored whether these alterations are also present in less well-characterized forms of FH, such as cases with no identified mutations, and whether they are fully corrected by current standard treatments.
Filiaciones:
Escola-Gil, JC:
Inst Invest Biomed IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Barcelona, Spain
CIBERDEM, CIBER Diabet & Enfermedades Metabol Asociadas, Madrid, Spain
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Barcelona, Spain
Rotllan, N:
Inst Invest Biomed IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Barcelona, Spain
CIBERDEM, CIBER Diabet & Enfermedades Metabol Asociadas, Madrid, Spain
Julve, J:
Inst Invest Biomed IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Barcelona, Spain
CIBERDEM, CIBER Diabet & Enfermedades Metabol Asociadas, Madrid, Spain
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Barcelona, Spain
Blanco-Vaca, F:
CIBERDEM, CIBER Diabet & Enfermedades Metabol Asociadas, Madrid, Spain
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Barcelona, Spain
Inst Invest Biomed IIB St Pau, Serv Bioquim, Hosp Santa Creu & St Pau, IIB, Barcelona, Spain
Open Access
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