Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
Por:
de Rojas, I, Moreno-Grau, S, Tesi, N, Grenier-Boley, B, Andrade, V, Pedersen, NL, Stringa, N, Zettergren, A, Hernandez, I, Montrreal, L, Antunez, C, Antonell, A, Tankard, RM, Bis, JC, Sims, R, Bellenguez, C, Quintela, I, Gonzalez-Perez, A, Calero, M, Franco-Macias, E, Macias, J, Blesa, R, Cervera-Carles, L, Menendez-Gonzalez, M, Frank-Garcia, A, Royo, JL, Moreno, F, Vilas, RH, Baquero, M, Diez-Fairen, M, Lage, C, Garcia-Madrona, S, Garcia-Gonzalez, P, Alarcon-Martin, E, Valero, S, Sotolongo-Grau, O, Ullgren, A, Naj, AC, Lemstra, AW, Benaque, A, Perez-Cordon, A, Benussi, A, Rabano, A, Padovani, A, Squassina, A, de Mendonca, A, Pastor, AA, Kok, AAL, Meggy, A, Pastor, AB, Espinosa, A, Corma-Gomez, A, Martin Montes, A, Sanabria, A, DeStefano, AL, Schneider, A, Haapasalo, A, Stahlbom, AK, Tybjaerg-Hansen, A, Hartmann, AM, Spottke, A, Corbaton-Anchuelo, A, Rongve, A, Borroni, B, Arosio, B, Nacmias, B, Nordestgaard, BG, Kunkle, BW, Charbonnier, C, Abdelnour, C, Masullo, C, Martinez Rodriguez, C, Munoz-Fernandez, C, Dufouil, C, Graff, C, Ferreira, CB, Chillotti, C, Reynolds, CA, Fenoglio, C, Van Broeckhoven, C, Clark, C, Pisanu, C, Satizabal, CL, Holmes, C, Buiza-Rueda, D, Aarsland, D, Rujescu, D, Alcolea, D, Galimberti, D, Wallon, D, Seripa, D, Grunblatt, E, Dardiotis, E, Duzel, E, Scarpini, E, Conti, E, Rubino, E, Gelpi, E, Rodriguez-Rodriguez, E, Duron, E, Boerwinkle, E, Ferri, E, Tagliavini, F, Kucukali, F, Pasquier, F, Sanchez-Garcia, F, Mangialasche, F, Jessen, F, Nicolas, G, Selbaek, G, Ortega, G, Chene, G, Hadjigeorgiou, G, Rossi, G, Spalletta, G, Giaccone, G, Grande, G, Binetti, G, Papenberg, G, Hampel, H, Bailly, H, Zetterberg, H, Soininen, H, Karlsson, IK, Alvarez, I, Appollonio, I, Giegling, I, Skoog, I, Saltvedt, I, Rainero, I, Allende, IR, Hort, J, Diehl-Schmid, J, Van Dongen, J, Vidal, JS, Lehtisalo, J, Wiltfang, J, Thomassen, JQ, Kornhuber, J, Haines, JL, Vogelgsang, J, Pineda, JA, Fortea, J, Popp, J, Deckert, J, Buerger, K, Morgan, K, Fliessbach, K, Sleegers, K, Molina-Porcel, L, Kilander, L, Weinhold, L, Farrer, LA, Wang, LS, Kleineidam, L, Farotti, L, Parnetti, L, Tremolizzo, L, Hausner, L, Benussi, L, Froelich, L, Ikram, MA, Deniz-Naranjo, MC, Tsolaki, M, Rosende-Roca, M, Lowenmark, M, Hulsman, M, Spallazzi, M, Pericak-Vance, MA, Esiri, M, Sanchez-Arjona, MB, Dalmasso, MC, Martinez-Larrad, MT, Arcaro, M, Nothen, MM, Fernandez-Fuertes, M, Dichgans, M, Ingelsson, M, Herrmann, MJ, Scherer, M, Vyhnalek, M, Kosmidis, MH, Yannakoulia, M, Schmid, M, Ewers, M, Heneka, MT, Wagner, M, Scamosci, M, Kivipelto, M, Hiltunen, M, Zulaica, M, Alegret, M, Fornage, M, Roberto, N, van Schoor, NM, Seidu, NM, Banaj, N, Armstrong, NJ, Scarmeas, N, Scherbaum, N, Goldhardt, O, Hanon, O, Peters, O, Skrobot, OA, Quenez, O, Lerch, O, Bossu, P, Caffarra, P, Rossi, PD, Sakka, P, Hoffmann, P, Holmans, PA, Fischer, P, Riederer, P, Yang, Q, Marshall, R, Kalaria, RN, Mayeux, R, Vandenberghe, R, Cecchetti, R, Ghidoni, R, Frikke-Schmidt, R, Sorbi, S, Hagg, S, Engelborghs, S, Helisalmi, S, Sando, SB, Kern, S, Archetti, S, Boschi, S, Fostinelli, S, Gil, S, Mendoza, S, Mead, S, Ciccone, S, Djurovic, S, Heilmann-Heimbach, S, Riedel-Heller, S, Kuulasmaa, T, del Ser, T, Lebouvier, T, Polak, T, Ngandu, T, Grimmer, T, Bessi, V, Escott-Price, V, Giedraitis, V, Deramecourt, V, Maier, W, Jian, XQ, Pijnenburg, YAL, Smith, AD, Abdelnour, C, Adarmes-Gomez, AD, Macleod, C, Jansen, IE, Kehoe, PG, Garcia-Ribas, G, Sanchez-Juan, P, Pastor, P, Perez-Tur, J, Pinol-Ripoll, G, de Munain, AL, Garcia-Alberca, JM, Bullido, MJ, Alvarez, V, Lleo, A, Real, LM, Mir, P, Medina, M, Scheltens, P, Holstege, H, Marquie, M, Saez, ME, Carracedo, A, Amouyel, P, Schellenberg, GD, Williams, J, Seshadri, S, van Duijn, CM, Mather, KA, Sanchez-Valle, R, Serrano-Rios, M, Orellana, A, Tarraga, L, Blennow, K, Huisman, M, Andreassen, OA, Posthuma, D, Clarimon, J, Boada, M, van der Flier, WM, Ramirez, A, Lambert, JC, van der Lee, SJ, Ruiz, A, EADB Contributors, GRAce Study Grp, DEGESCO Consortium, IGAP, PGC-ALZ Consortia
Publicada:
7 jun 2021
Resumen:
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n=409,435 and validation size n=58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE 4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease. Known genetic loci account for only a fraction of the genetic contribution to Alzheimer's disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer's disease polygenic risk score.
Filiaciones:
de Rojas, I:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Moreno-Grau, S:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Tesi, N:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Dept Clin Genet, Amsterdam UMC, Amsterdam, Netherlands
Delft Univ Technol, Delft Bioinformat Lab, Delft, Netherlands
Grenier-Boley, B:
Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,U1167 Labex DISTALZ RID AGE Risk Factor, Lille, France
Andrade, V:
Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany
Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Pedersen, NL:
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Stringa, N:
Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands
Zettergren, A:
Univ Gothenburg, Ctr Ageing & Hlth AgeCap, Neuropsychiat Epidemiol Unit,Sahlgrenska Acad, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Hernandez, I:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Montrreal, L:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Antunez, C:
Hosp Clin Univ Virgen Arrixaca, Unidad Demencias, Murcia, Spain
Antonell, A:
Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Tankard, RM:
Murdoch Univ, Math & Stat, Perth, WA, Australia
Bis, JC:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Sims, R:
Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Bellenguez, C:
Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,U1167 Labex DISTALZ RID AGE Risk Factor, Lille, France
Quintela, I:
Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Santiago De Compostela, Spain
Gonzalez-Perez, A:
Ctr Andaluz Estudios Bioinformat, Seville, Spain
Calero, M:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Inst Salud Carlos III, UFIEC, Madrid, Spain
Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain
Franco-Macias, E:
Univ Seville, CSIC, Inst Biomed Sevilla IBiS, Unidad Demencias,Serv Neurol & Neurofisiol,Hosp U, Seville, Spain
Macias, J:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Blesa, R:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain
Cervera-Carles, L:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain
Menendez-Gonzalez, M:
Hosp Univ Cent Asturias, Serv Neurol, Oviedo, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
Univ Oviedo, Dept Med, Oviedo, Spain
Frank-Garcia, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
La Paz Univ Hosp, Dept Neurol, Inst Invest Sanitaria Hosp Univ La Paz, IdiPAZ, Madrid, Spain
Hosp La Paz Inst Hlth Res, IdiPAZ, Madrid, Spain
Univ Autonoma Madrid, Madrid, Spain
Royo, JL:
Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Sch Med, Malaga, Spain
Moreno, F:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Univ Donostia, Dept Neurol, San Sebastian, Spain
Inst Biodonostia, Neurosci Area, San Sebastian, Spain
Vilas, RH:
Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain
Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
Baquero, M:
Hosp Univ & Politecn La Fe, Serv Neurol, Valencia, Spain
Diez-Fairen, M:
Fundacio Docencia & Recerca MutuaTerrassa, Barcelona, Spain
Hosp Univ Mutua Terrassa, Memory Disorders Unit, Dept Neurol, Barcelona, Spain
Lage, C:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Cantabria, Univ Hosp, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain
IDIVAL, Santander, Spain
Garcia-Madrona, S:
Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain
Garcia-Gonzalez, P:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Alarcon-Martin, E:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Sch Med, Malaga, Spain
Valero, S:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Sotolongo-Grau, O:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Ullgren, A:
Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden
Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Stockholm, Sweden
Naj, AC:
Univ Penn, Dept Biostat Epidemiol & Informat, Perelman Sch Med, Philadelphia, PA 19104 USA
Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA
Lemstra, AW:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Benaque, A:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Perez-Cordon, A:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Benussi, A:
Univ Brescia, Dept Clin & Expt Sci, Ctr Neurodegenerat Disorders, Brescia, Italy
Rabano, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain
BT CIEN, Madrid, Spain
Padovani, A:
Univ Brescia, Dept Clin & Expt Sci, Ctr Neurodegenerat Disorders, Brescia, Italy
Squassina, A:
Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, Cagliari, Italy
de Mendonca, A:
Univ Lisbon, Fac Med, Lisbon, Portugal
Pastor, AA:
Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain
Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
Kok, AAL:
Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam UMC, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
Meggy, A:
Cardiff Univ, UK Dementia Res Inst Cardiff, Cardiff, Wales
Pastor, AB:
Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain
BT CIEN, Madrid, Spain
Espinosa, A:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Corma-Gomez, A:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Martin Montes, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp La Paz Inst Hlth Res, IdiPAZ, Madrid, Spain
La Paz Univ Hosp, Dept Neurol, La Paz, Spain
Sanabria, A:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
DeStefano, AL:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Schneider, A:
Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Haapasalo, A:
Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland
Stahlbom, AK:
Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden
Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Stockholm, Sweden
Tybjaerg-Hansen, A:
Rigshosp, Dept Clin Biochem, Copenhagen, Denmark
Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
Hartmann, AM:
Martin Luther Univ Halle Wittenberg, Univ Clin & Outpatient Clin Psychiat Psychotherap, Halle, Saale, Germany
Spottke, A:
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Bonn, Dept Neurol, Bonn, Germany
Corbaton-Anchuelo, A:
Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Madrid, Spain
Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain
Rongve, A:
Haugesund Hosp, Helse Fonna, Dept Res & Innovat, Haugesund, Norway
Univ Bergen, Inst Clin Med K1, Bergen, Norway
Borroni, B:
Univ Brescia, Dept Clin & Expt Sci, Ctr Neurodegenerat Disorders, Brescia, Italy
Arosio, B:
Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy
IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Geriatr Unit, Milan, Italy
Nacmias, B:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
IRCCS Fdn Don Carlo Gnocchi, Florence, Italy
Nordestgaard, BG:
Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
Herlev Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark
Kunkle, BW:
Univ Miami, Miller Sch Med, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL 33136 USA
Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA
Charbonnier, C:
Normandie Univ, UNIROUEN, INSERM, CHU Rouen,Dept Genet,U1245, F-76000 Rouen, France
CNR MAJ, FHU G4 Genom, F-76000 Rouen, France
Abdelnour, C:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Masullo, C:
Univ Cattolica Sacro Cuore, Sch Med, Inst Neurol, Milan, Italy
Martinez Rodriguez, C:
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
Hosp Cabuenes, Gijon, Spain
Munoz-Fernandez, C:
Hosp Univ Gran Canaria Dr Negrin, Serv Neurol, Las Palmas Gran Canaria, Spain
Dufouil, C:
Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, UMR 1219,ISPED,CIC 1401 EC, Bordeaux, France
CHU Bordeaux, Pole Sante Publ, Bordeaux, France
Graff, C:
Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden
Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Stockholm, Sweden
Ferreira, CB:
Univ Lisbon, Inst Med Mol Joao Lobo Antunes, Fac Med, Lisbon, Portugal
Chillotti, C:
Univ Hosp Cagliari, Unit Clin Pharmacol, Cagliari, Italy
Reynolds, CA:
Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA
Fenoglio, C:
Univ Milan, Dino Ferrari Ctr, Milan, Italy
Van Broeckhoven, C:
VIB Ctr Mol Neurol, Antwerp, Belgium
Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Clark, C:
Univ Zurich, Inst Regenerat Med, Zurich, Switzerland
Pisanu, C:
Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, Cagliari, Italy
Satizabal, CL:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
UT Hlth San Antonio, Dept Populat Hlth Sci, San Antonio, TX USA
Holmes, C:
Univ Southampton, Sch Med, Div Clin Neurosci, Southampton, Hants, England
Buiza-Rueda, D:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Seville, CSIC, Inst Biomed Sevilla IBiS,Hosp Univ Virgen del Roc, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Aarsland, D:
Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Old Age Psychiat, London, England
Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway
Rujescu, D:
Martin Luther Univ Halle Wittenberg, Univ Clin & Outpatient Clin Psychiat Psychotherap, Halle, Saale, Germany
Alcolea, D:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain
Galimberti, D:
Univ Milan, Dino Ferrari Ctr, Milan, Italy
Fdn IRCCS Ca Granda Osped Policlin, Milan, Italy
Wallon, D:
Normandie Univ, UNIROUEN, INSERM, CHU Rouen,Dept Neurol,U1245, Rouen, France
Seripa, D:
Fdn IRCCS Casa Sollievo Sofferenza, Complex Struct Geriatr, Dept Med Sci, San Giovanni Rotondo, FG, Italy
Grunblatt, E:
Univ Zurich, Psychiat Univ Hosp Zurich PUK, Dept Child & Adolescent Psychiat & Psychothera, Zurich, Switzerland
Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland
Swiss Fed Inst Technol, Zurich, Switzerland
Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland
Dardiotis, E:
Univ Thessaly, Sch Med, Larisa, Greece
Duzel, E:
German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany
Otto Von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany
Scarpini, E:
Univ Milan, Dino Ferrari Ctr, Milan, Italy
Fdn IRCCS Ca Granda Osped Policlin, Milan, Italy
Conti, E:
Univ Milano Bicocca, Sch Med & Surg, Milan, Italy
Milan Ctr Neurosci, Milan, Italy
Rubino, E:
AOU Citta Salute & Sci Torino, Dept Neurosci & Mental Hlth, Turin, Italy
Gelpi, E:
Hosp Clin Barcelona, IDIBAPS, Neurol Tissue Bank Biobanc, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Med Univ Vienna, Div Neuropathol & Neurochem, Dept Neurol, Vienna, Austria
Rodriguez-Rodriguez, E:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Cantabria, Univ Hosp, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain
IDIVAL, Santander, Spain
Duron, E:
Hop Brousse, APHP, Equipe INSERM 1178, MOODS, Villejuif, France
Univ Paris Saclay, UVSQ, INSERM, CESP,Team MOODS, Le Kremlin Bicetre, France
Hop Broca, APHP, Paris, France
Boerwinkle, E:
Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA
Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
Ferri, E:
IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Geriatr Unit, Milan, Italy
Tagliavini, F:
Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy
Kucukali, F:
VIB Ctr Mol Neurol, Antwerp, Belgium
Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Pasquier, F:
Univ Lille, LiCEND, INSERM, CHU,DISTAlz,U1172, Lille, France
CHU CNR MAJ, Lille, France
Sanchez-Garcia, F:
Hosp Univ Gran Canaria Dr Negrin, Serv Inmunol, Las Palmas Gran Canaria, Spain
Mangialasche, F:
Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden
Jessen, F:
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne, Germany
Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany
Nicolas, G:
Hosp Cabuenes, Gijon, Spain
Selbaek, G:
Vestfold Hosp Trust, Norwegian Natl Advisory Unit Ageing & Hlth, Tonsberg, Norway
Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway
Univ Oslo, Inst Clin Med, Oslo, Norway
Ortega, G:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Chene, G:
Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, UMR 1219,ISPED,CIC 1401 EC, Bordeaux, France
CHU Bordeaux, Pole Sante Publ, Bordeaux, France
Hadjigeorgiou, G:
Univ Cyprus, Sch Med, Dept Neurol, Nicosia, Cyprus
Rossi, G:
Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy
Spalletta, G:
IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy
Baylor Coll Med, Dept Psychiat & Behav Sci, Beth K & Stuart C Yudofsky Div Neuropsychiat, Houston, TX 77030 USA
Giaccone, G:
Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy
Grande, G:
Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
Stockholm Univ, Stockholm, Sweden
Binetti, G:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, MAC Memory Clin, Brescia, Italy
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Papenberg, G:
Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
Stockholm Univ, Stockholm, Sweden
Hampel, H:
Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Alzheimer Precis Med,GRC 21, Paris, France
Bailly, H:
Hop Broca, APHP, Paris, France
Univ Paris 05, Sorbonne Paris Cite, EA 4468, Paris, France
Zetterberg, H:
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Univ Gothenburg, Dept Psychiat & Neurochemi, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
UCL Inst Neurol, Dept Neurodegenerat Dis, London, England
UCL, UK Dementia Res Inst, London, England
Soininen, H:
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
Kuopio Univ Hosp, Neurol, Neuroctr, Kuopio, Finland
Karlsson, IK:
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Jonkoping Univ, Inst Gerontol & Aging Res Network Jonkoping ARN J, Jonkoping, Sweden
Alvarez, I:
Fundacio Docencia & Recerca MutuaTerrassa, Barcelona, Spain
Hosp Univ Mutua Terrassa, Memory Disorders Unit, Dept Neurol, Barcelona, Spain
Appollonio, I:
Univ Milano Bicocca, Sch Med & Surg, Milan, Italy
Milan Ctr Neurosci, Milan, Italy
San Gerardo Hosp, Neurol Unit, Monza, Italy
Giegling, I:
Martin Luther Univ Halle Wittenberg, Univ Clin & Outpatient Clin Psychiat Psychotherap, Halle, Saale, Germany
Skoog, I:
Univ Gothenburg, Ctr Ageing & Hlth AgeCap, Neuropsychiat Epidemiol Unit,Sahlgrenska Acad, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Saltvedt, I:
Univ Hosp Trondheim, Dept Geriatr, Med Clin, St Olavs Hosp, Trondheim, Norway
Norwegian Univ Sci & Technhol NTNU, Dept Neuromed & Movement Sci, Trondheim, Norway
Rainero, I:
Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy
Allende, IR:
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain
Hort, J:
Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Prague, Czech Republic
Charles Univ Prague, Motol Univ Hosp, Prague, Czech Republic
St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic
Diehl-Schmid, J:
Tech Univ Munich, Klinikum Rechts Isar, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany
Van Dongen, J:
VIB Ctr Mol Neurol, Antwerp, Belgium
Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Vidal, JS:
Hop Broca, APHP, Paris, France
Univ Paris 05, Sorbonne Paris Cite, EA 4468, Paris, France
Lehtisalo, J:
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki, Finland
Wiltfang, J:
Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany
Univ Aveiro, Dept Med Sci, Neurosci & Signaling Grp, Inst Biomed iBiMED, Aveiro, Portugal
Thomassen, JQ:
Rigshosp, Dept Clin Biochem, Copenhagen, Denmark
Kornhuber, J:
Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
Haines, JL:
Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA
Case Western Reserve Univ, Cleveland Inst Computat Biol, Cleveland, OH 44106 USA
Vogelgsang, J:
Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
Harvard Med Sch, McLean Hosp, Translat Neurosci Lab, Belmont, MA USA
Pineda, JA:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Fortea, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain
Popp, J:
Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland
Univ Zurich, Zurich, Switzerland
Univ Hosp Lausanne, Old Age Psychiat, Lausanne, Switzerland
Deckert, J:
Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany
Buerger, K:
Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany
German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Morgan, K:
Univ Nottingham, Sch Life Sci, Nottingham, England
Univ Nottingham, Sch Med, Nottingham, England
Fliessbach, K:
Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Sleegers, K:
VIB Ctr Mol Neurol, Antwerp, Belgium
Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Molina-Porcel, L:
Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Hosp Clin Barcelona, IDIBAPS, Neurol Tissue Bank Biobanc, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Kilander, L:
Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Weinhold, L:
Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany
Farrer, LA:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Epidemiol, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Biostat, Boston, MA 02118 USA
Boston Univ, Sch Publ Hlth, Boston, MA USA
Wang, LS:
Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA
Kleineidam, L:
Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany
Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Farotti, L:
Univ Perugia, Lab Clin Neurochem, Ctr Memory Disturbances, Neurol Sect, Perugia, Italy
Parnetti, L:
Univ Perugia, Lab Clin Neurochem, Ctr Memory Disturbances, Neurol Sect, Perugia, Italy
Tremolizzo, L:
Univ Milano Bicocca, Sch Med & Surg, Milan, Italy
Milan Ctr Neurosci, Milan, Italy
San Gerardo Hosp, Neurol Unit, Monza, Italy
Hausner, L:
Heidelberg Univ, Med Fac Mannheim, Dept Geriatr Psychiat, Cent Inst Mental Hlth Mannheim, Heidelberg, Germany
Benussi, L:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Froelich, L:
Heidelberg Univ, Med Fac Mannheim, Dept Geriatr Psychiat, Cent Inst Mental Hlth Mannheim, Heidelberg, Germany
Ikram, MA:
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
Deniz-Naranjo, MC:
Hosp Univ Gran Canaria Dr Negrin, Serv Inmunol, Las Palmas Gran Canaria, Spain
Tsolaki, M:
Aristotle Univ Thessaloniki, Dept Neurol 1, Thessaloniki, Greece
Rosende-Roca, M:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Lowenmark, M:
Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Hulsman, M:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Dept Clin Genet, Amsterdam UMC, Amsterdam, Netherlands
Spallazzi, M:
Azienda Osped Univ, Parma, Italy
Pericak-Vance, MA:
Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA
Esiri, M:
Nuffield Dept Clin Neurosci, Oxford, England
Sanchez-Arjona, MB:
Univ Seville, CSIC, Inst Biomed Sevilla IBiS, Unidad Demencias,Serv Neurol & Neurofisiol,Hosp U, Seville, Spain
Dalmasso, MC:
Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany
Martinez-Larrad, MT:
Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Madrid, Spain
Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain
Arcaro, M:
Fdn IRCCS Ca Granda Osped Policlin, Milan, Italy
Nothen, MM:
Univ Bonn, Inst Human Genet, Sch Med, Bonn, Germany
Univ Hosp Bonn, Bonn, Germany
Fernandez-Fuertes, M:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Dichgans, M:
Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany
German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Munich Cluster Syst Neurol SyNergy, Munich, Germany
Ingelsson, M:
Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Herrmann, MJ:
Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany
Scherer, M:
Univ Med Ctr Hamburg Eppendorf, Dept Primary Med Care, Hamburg, Germany
Vyhnalek, M:
Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Prague, Czech Republic
Charles Univ Prague, Motol Univ Hosp, Prague, Czech Republic
St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic
Kosmidis, MH:
Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Greece
Yannakoulia, M:
Harokopio Univ, Dept Nutr & Dietet, Athens, Greece
Schmid, M:
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany
Ewers, M:
Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany
German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Heneka, MT:
Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Wagner, M:
Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Scamosci, M:
Univ Perugia, Inst Gerontol & Geriatr, Dept Med, Perugia, Italy
Kivipelto, M:
Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden
Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
Imperial Coll London, Neuroepidemiol & Ageing Res Unit, Sch Publ Hlth, London, England
Stockholms Sjukhem, Res & Dev Unit, Stockholm, Sweden
Hiltunen, M:
Univ Eastern Finland, Inst Biomed, Kuopio, Finland
Zulaica, M:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Inst Biodonostia, Neurosci Area, San Sebastian, Spain
Alegret, M:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Fornage, M:
Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Houston, TX 77030 USA
Roberto, N:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
van Schoor, NM:
Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands
Seidu, NM:
Univ Gothenburg, Ctr Ageing & Hlth AgeCap, Neuropsychiat Epidemiol Unit,Sahlgrenska Acad, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Banaj, N:
IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy
Armstrong, NJ:
Murdoch Univ, Math & Stat, Perth, WA, Australia
Scarmeas, N:
Natl & Kapodistrian Univ Athens, Dept Neurol 1, Aiginit Hosp, Sch Med, Athens, Greece
Columbia Univ, Gertrude H Sergievsky Ctr, Depatment Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA
Scherbaum, N:
Univ Duisburg Essen, LVR Hosp Essen, Dept Psychiat & Psychotherapy, Fac Med, Essen, Germany
Goldhardt, O:
Tech Univ Munich, Klinikum Rechts Isar, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany
Hanon, O:
Hop Broca, APHP, Paris, France
Univ Paris 05, Sorbonne Paris Cite, EA 4468, Paris, France
Peters, O:
Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany
Charite Univ Med Berlin, Expt & Clin Res Ctr ECRC, Berlin, Germany
German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
Skrobot, OA:
Univ Bristol, Southmead Hosp, Bristol Med Sch THS, Bristol, Avon, England
Quenez, O:
Normandie Univ, UNIROUEN, INSERM, CHU Rouen,Dept Genet,U1245, F-76000 Rouen, France
CNR MAJ, FHU G4 Genom, F-76000 Rouen, France
Lerch, O:
Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Prague, Czech Republic
Charles Univ Prague, Motol Univ Hosp, Prague, Czech Republic
St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic
Bossu, P:
IrCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Expt Neuropsychobiol Lab, Rome, Italy
Caffarra, P:
Univ Parma, DIMEC, Unit Neurosci, Parma, Italy
Rossi, PD:
IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Geriatr Unit, Milan, Italy
Sakka, P:
Athens Assoc Alzheimers Dis & Related Disorders, Athens, Greece
Hoffmann, P:
Univ Bonn, Inst Human Genet, Sch Med, Bonn, Germany
Univ Hosp Bonn, Bonn, Germany
Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland
Holmans, PA:
Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Fischer, P:
Social Med Ctr East Donauspital, Dept Psychiat, Vienna, Austria
Riederer, P:
Univ Hosp Wurzburg, Clin & Policlin Psychiat Psychosomat & Psychother, Ctr Mental Hlth, Wurzburg, Germany
Yang, Q:
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Marshall, R:
Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Kalaria, RN:
Newcastle Univ, Translat & Clincial Res Inst, Newcastle Upon Tyne, Tyne & Wear, England
Campus Ageing Anf Vital, Newcastle Upon Tyne, Tyne & Wear, England
Mayeux, R:
Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY USA
Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA
Columbia Univ, Dept Neurol, New York, NY USA
Vandenberghe, R:
Univ Leuven, Dept Neurosci, Lab Cognit Neurol, Leuven, Belgium
Univ Hosp Leuven, Dept Neurol, Leuven, Belgium
Cecchetti, R:
Univ Perugia, Inst Gerontol & Geriatr, Dept Med, Perugia, Italy
Ghidoni, R:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Frikke-Schmidt, R:
Rigshosp, Dept Clin Biochem, Copenhagen, Denmark
Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
Sorbi, S:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
IRCCS Fdn Don Carlo Gnocchi, Florence, Italy
Hagg, S:
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Engelborghs, S:
Vrije Univ Brussel, Ctr Neurosci, Brussels, Belgium
Univ Antwerp, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Antwerp, Belgium
VUB Univ Hosp Brussels UZ Brussel, Dept Neurol, Brussels, Belgium
Helisalmi, S:
Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland
Sando, SB:
Univ Hosp Trondheim, Dept Neurol & Clin Neurophysiol, Trondheim, Norway
Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway
Kern, S:
Univ Gothenburg, Ctr Ageing & Hlth AgeCap, Neuropsychiat Epidemiol Unit,Sahlgrenska Acad, Dept Psychiat & Neurochem,Inst Neurosci & Physiol, Gothenburg, Sweden
Archetti, S:
Brescia Hosp, Lab Anal 3, Dept Lab Diagnost, Brescia, Italy
Boschi, S:
Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy
Fostinelli, S:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Gil, S:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Mendoza, S:
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Mead, S:
UCL, Inst Prion Dis, MRC Prion Unit, London, England
Ciccone, S:
IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Geriatr Unit, Milan, Italy
Djurovic, S:
Oslo Univ Hosp, Dept Med Genet, Oslo, Norway
Univ Bergen, NORMENT, Dept Clin Sci, Bergen, Norway
Heilmann-Heimbach, S:
Univ Bonn, Inst Human Genet, Sch Med, Bonn, Germany
Univ Hosp Bonn, Bonn, Germany
Riedel-Heller, S:
Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, Leipzig, Germany
Kuulasmaa, T:
Univ Eastern Finland, Inst Biomed, Kuopio, Finland
del Ser, T:
Queen Sofia Fdn Alzheimer Ctr, Dept Neurol, CIEN Fdn, Madrid, Spain
Lebouvier, T:
Univ Lille, LiCEND, INSERM, CHU,DISTAlz,U1172, Lille, France
CHU CNR MAJ, Lille, France
Polak, T:
Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany
Ngandu, T:
Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Ctr Alzheimer Res, Stockholm, Sweden
Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki, Finland
Grimmer, T:
Tech Univ Munich, Klinikum Rechts Isar, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany
Bessi, V:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
Azienda Osped Univ Careggi Largo Brambilla, Florence, Italy
Escott-Price, V:
Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Cardiff Univ, UKDRI Cardiff, Cardiff, Wales
Giedraitis, V:
Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Deramecourt, V:
Univ Lille, LiCEND, INSERM, CHU,DISTAlz,U1172, Lille, France
CHU CNR MAJ, Lille, France
Maier, W:
Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Jian, XQ:
Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Pijnenburg, YAL:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Abdelnour, C:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Jansen, IE:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Complex Trait Genet, Amsterdam Neurosci, Amsterdam, Netherlands
Kehoe, PG:
German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
Garcia-Ribas, G:
Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain
Sanchez-Juan, P:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Cantabria, Univ Hosp, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain
IDIVAL, Santander, Spain
Pastor, P:
Fundacio Docencia & Recerca MutuaTerrassa, Barcelona, Spain
Hosp Univ Mutua Terrassa, Memory Disorders Unit, Dept Neurol, Barcelona, Spain
Perez-Tur, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
CSIC, Inst Biomed Valencia, Unitat Genet Mol, Valencia, Spain
Inst Invest Sanitaria La Fe, Unidad Mixta Neurol Genet, Valencia, Spain
Pinol-Ripoll, G:
Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain
Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
de Munain, AL:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Univ Donostia, Dept Neurol, San Sebastian, Spain
Inst Biodonostia, Neurosci Area, San Sebastian, Spain
Univ Basque Country, Dept Neurosci, Fac Med & Nursery, San Sebastian, Spain
Garcia-Alberca, JM:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Bullido, MJ:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Madrid, Madrid, Spain
UAM, Ctr Biol Mol Severo Ochoa, CSIC, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Alvarez, V:
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain
Lleo, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain
Real, LM:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Univ Malaga, Fac Med, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain
Mir, P:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Seville, CSIC, Inst Biomed Sevilla IBiS,Hosp Univ Virgen del Roc, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Medina, M:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain
Scheltens, P:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Holstege, H:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Dept Clin Genet, Amsterdam UMC, Amsterdam, Netherlands
Marquie, M:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Saez, ME:
Ctr Andaluz Estudios Bioinformat, Seville, Spain
Carracedo, A:
Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Santiago De Compostela, Spain
Fdn Publ Galega Med Xen CIBERER IDIS, Santiago De Compostela, Spain
Amouyel, P:
Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,U1167 Labex DISTALZ RID AGE Risk Factor, Lille, France
Schellenberg, GD:
Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA
Williams, J:
Cardiff Univ, Div Psychol Med & Clinial Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Cardiff Univ, UK Dementia Res Inst Cardiff, Cardiff, Wales
Seshadri, S:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
van Duijn, CM:
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Mather, KA:
Univ New South Wales, Fac Med, Sch Psychiat, Ctr Hlth Brain Ageing CHeBA, Sydney, NSW, Australia
Neurosci Res Australia, Sydney, NSW, Australia
Sanchez-Valle, R:
Univ Barcelona, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol,Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Serrano-Rios, M:
Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Madrid, Spain
Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain
Orellana, A:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Tarraga, L:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Blennow, K:
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Univ Gothenburg, Dept Psychiat & Neurochemi, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
Huisman, M:
Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands
Vrije Univ Amsterdam, Dept Sociol, Amsterdam, Netherlands
Andreassen, OA:
Univ Oslo, Inst Clin Med, NORMENT Ctr, Oslo, Norway
Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
Posthuma, D:
Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Complex Trait Genet, Amsterdam Neurosci, Amsterdam, Netherlands
Clarimon, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain
Boada, M:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
van der Flier, WM:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Ramirez, A:
Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany
Univ Clin Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, Dept Psychiat, San Antonio, TX USA
Lambert, JC:
Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,U1167 Labex DISTALZ RID AGE Risk Factor, Lille, France
van der Lee, SJ:
Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands
Vrije Univ Amsterdam, Sect Genom Neurodegenerat Dis & Aging, Dept Clin Genet, Amsterdam UMC, Amsterdam, Netherlands
Ruiz, A:
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Green Published, Green Accepted, gold, Green Submitted
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