Defective involuntary attention to novelty in type 1 diabetes and impaired awareness of hypoglycaemia
Por:
Stantonyonge, N, Martinez-Horta, S, Sampedro, F, Sanchez-Saudinos, MB, Chico, A
Publicada:
1 jul 2021
Ahead of Print:
1 jun 2021
Resumen:
Aim: To determine if there are differences in terms of neurophysiology and neurocognitive functioning in a group of type 1 diabetes (T1D) patients regarding hypoglycaemia awareness. Methods: 27 patients with T1D were classified according to Clarke score as having impaired awareness of hypoglycaemia (IAH; n = 11) or normal awareness to hypoglycaemia (NAH; n = 16). We measured several clinical and sociodemographic variables and cognitive performance using neuropsychological tests. Electroencephalography was assessed during an auditory oddball task. We compared the groups in terms of clinical/sociodemographic variables as well as two event-related brain potentials (ERPs): The P3a which is associated with automatic orientation of attention to novelty, and the P3b which is associated with target detection and processing. Results: The IAH group performed significantly worse on the Trail Making Test part A (TMTA) (p = 0.05). Compared to the NAH group, P3a and P3b amplitudes in the frontal-central sites were significantly lower in the IAH group (p < 0.05). The P3a was strongly associated with worse performance on the TMT-A in the IAH group (r = 0.540; p < 0.005) Conclusion: IAH is accompanied by decreased neurophysiological activity in ERPs associated with information processing and with the automatic orientation of attention to novelty and environmental changes. These findings suggest a possible framework to better understand the cognitive origin of IAH in this patient population. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Filiaciones:
Stantonyonge, N:
Hosp Santa Creu & Sant Pau, Dept Endocrinol & Nutr, Mas Casanovas 90, Barcelona 08041, Spain
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Martinez-Horta, S:
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Barcelona, Spain
Sampedro, F:
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Barcelona, Spain
Sanchez-Saudinos, MB:
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Santa Creu & Sant Pau, Memory Unit, Neurol Dept, Barcelona, Spain
Chico, A:
Hosp Santa Creu & Sant Pau, Dept Endocrinol & Nutr, Mas Casanovas 90, Barcelona 08041, Spain
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Inst Salud Carlos III, CIBER Bioengn Biomat & Nanotechnol CIBER BBN, Madrid, Spain
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