A Novel NFIX-STAT6 Gene Fusion in Solitary Fibrous Tumor: A Case Report


Por: Moura, DS, Diaz-Martin, J, Bague, S, Orellana-Fernandez, R, Sebio, A, Mondaza-Hernandez, JL, Salguero-Aranda, C, Rojo, F, Hindi, N, Fletcher, CDM, Martin-Broto, J

Publicada: 1 jul 2021
Resumen:
Solitary fibrous tumor is a rare subtype of soft-tissue sarcoma with a wide spectrum of histopathological features and clinical behaviors, ranging from mildly to highly aggressive tumors. The defining genetic driver alteration is the gene fusion NAB2-STAT6, resulting from a paracentric inversion within chromosome 12q, and involving several different exons in each gene. STAT6 (signal transducer and activator of transcription 6) nuclear immunostaining and/or the identification of NAB2-STAT6 gene fusion is required for the diagnostic confirmation of solitary fibrous tumor. In the present study, a new gene fusion consisting of Nuclear Factor I X (NFIX), mapping to 19p13.2 and STAT6, mapping to 12q13.3 was identified by targeted RNA-Seq in a 74-year-old female patient diagnosed with a deep-seated solitary fibrous tumor in the pelvis. Histopathologically, the neoplasm did not display nuclear pleomorphism or tumor necrosis and had a low proliferative index. A total of 378 unique reads spanning the NFIXexon8-STAT6exon2 breakpoint with 55 different start sites were detected in the bioinformatic analysis, which represented 59.5% of the reads intersecting the genomic location on either side of the breakpoint. Targeted RNA-Seq results were validated by RT-PCR/ Sanger sequencing. The identification of a new gene fusion partner for STAT6 in solitary fibrous tumor opens intriguing new hypotheses to refine the role of STAT6 in the sarcomatogenesis of this entity.

Filiaciones:
Moura, DS:
 US, Inst Biomed Seville, IBiS, HUVR,CSIC, Seville 41013, Spain

Diaz-Martin, J:
 US, Inst Biomed Seville, IBiS, HUVR,CSIC, Seville 41013, Spain

 Hosp Virgen del Rocio, Pathol Dept, Seville 41013, Spain

 Ctr Invest Bionand Red Canc CIBERONC, Madrid 28029, Spain

Bague, S:
 St Pau Hosp, Pathol Dept CIBERONC, Barcelona 08041, Spain

Orellana-Fernandez, R:
 St Pau Hosp, Pathol Dept CIBERONC, Barcelona 08041, Spain

Sebio, A:
 St Pau Hosp, Med Oncol Dept, Barcelona 08041, Spain

Mondaza-Hernandez, JL:
 Fdn Jimenez Diaz Univ Hosp Hlth Res Inst IIS FJD, Madrid 28015, Spain

Salguero-Aranda, C:
 US, Inst Biomed Seville, IBiS, HUVR,CSIC, Seville 41013, Spain

 Hosp Virgen del Rocio, Pathol Dept, Seville 41013, Spain

 Ctr Invest Bionand Red Canc CIBERONC, Madrid 28029, Spain

Rojo, F:
 Fdn Jimenez Diaz Univ Hosp, Pathol Dept, Madrid 28040, Spain

Hindi, N:
 Fdn Jimenez Diaz Univ Hosp Hlth Res Inst IIS FJD, Madrid 28015, Spain

 Fdn Jimenez Diaz Univ Hosp, Med Oncol Dept, Madrid 28040, Spain

 Gen de Villalba Univ Hosp, Madrid 28400, Spain

Fletcher, CDM:
 Brigham & Womens Hosp, Dept Pathol, Boston, MA 02215 USA

 Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA

Martin-Broto, J:
 Fdn Jimenez Diaz Univ Hosp Hlth Res Inst IIS FJD, Madrid 28015, Spain

 Fdn Jimenez Diaz Univ Hosp, Med Oncol Dept, Madrid 28040, Spain

 Gen de Villalba Univ Hosp, Madrid 28400, Spain
ISSN: 16616596
Editorial
MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 22 Número: 14
Páginas:
WOS Id: 000676209200001
ID de PubMed: 34299133
imagen gold, Green Published

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