Oral submucous fibrosis presenting with histopathological lichenoid changes as predominant feature: Report of five cases and review of the literature
Por:
Campos, MC, Tubau, C, Segura, S, Gonzalez-Farre, M, Iglesias-Sancho, M, Fernandez-Figueras, MT, Garcia-Muret, MP, Mozos, A
Publicada:
1 nov 2021
Ahead of Print:
1 jul 2021
Resumen:
Oral submucous fibrosis (OSF) is a precancerous condition of the oral cavity associated with habitual chewing of quid, with a high incidence among populations of the Indian subcontinent and Southeast Asia. Clinically, its initial manifestation may mimic oral lichen planus or lichen sclerosus. If the habit is not halted, the mucosa gets leathery and thickened, and fibrous bands form causing significant morbidity. Microscopically, it is characterized by atrophic epithelium, loss of rete ridges, and hyalinization of lamina propria. Of note, these hallmark histopathological features may be overlooked in the unusual presence of lichenoid interface changes, which may lead to the wrong diagnosis. We present herein five cases in which the rare joint appearance of OSF and lichenoid reaction features posed a diagnostic challenge. Due to its progressive nature and malignant potential, the presence of oral lichenoid changes overlying submucous hyalinization, in the right clinical and demographic setting, should raise suspicion of OSF and prompt actions directed at quid-chewing discontinuation.
Filiaciones:
Campos, MC:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Pathol, Barcelona, Spain
Tubau, C:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Dermatol, Barcelona, Spain
Segura, S:
Univ Autonoma Barcelona, Hosp Mar, Dept Dermatol, Barcelona, Spain
Gonzalez-Farre, M:
Univ Autonoma Barcelona, Hosp Mar, Dept Pathol, Barcelona, Spain
Iglesias-Sancho, M:
Hosp Univ Sagrat Cor, Grp Quironsalud, Dept Dermatol, Barcelona, Spain
Fernandez-Figueras, MT:
Hosp Univ Gen Catalunya, Grp Quironsalud, Dept Pathol, Barcelona, Spain
Garcia-Muret, MP:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Dermatol, Barcelona, Spain
Mozos, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Pathol, Barcelona, Spain
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