In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study
Por:
Grothe, MJ, Labrador-Espinosa, MA, Jesus, S, Macias-Garcia, D, Adarmes-Gomez, A, Carrillo, F, Camacho, EI, Franco-Rosado, P, Lora, FR, Martin-Rodriguez, JF, Barbera, MA, Pastor, P, Arroyo, SE, Vila, BS, Foraster, AC, Martinez, JR, Padilla, FC, Morlans, MP, Aramburu, IG, Ceberio, JI, Vara, JH, de Fabregues-Boixar, O, Fonticoba, TD, Pascual-Sedano, B, Kulisevsky, J, Martinez-Martin, P, Santos-Garcia, D, Mir, P
Publicada:
1 jul 2021
Ahead of Print:
1 jun 2021
Resumen:
Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia.
Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models.
Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r = 0.37, p < 0.001), and this association remained significant after controlling for several potential confounding variables (p = 0.004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p = 0.02).
Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD.
Filiaciones:
Grothe, MJ:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Labrador-Espinosa, MA:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Jesus, S:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Macias-Garcia, D:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Adarmes-Gomez, A:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Carrillo, F:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Camacho, EI:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Franco-Rosado, P:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Lora, FR:
Hosp Univ Virgen Rocio, Unidad Radiodiagnost, Seville, Spain
Martin-Rodriguez, JF:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Barbera, MA:
Hosp Univ Mutua Terrassa, Barcelona, Spain
Pastor, P:
Hosp Univ Mutua Terrassa, Barcelona, Spain
Arroyo, SE:
Hosp Tortosa Verge Cinta HTVC, Tarragona, Spain
Vila, BS:
Inst Catala Salud Girona, Inst Assistencia Sanitaria IAS, Girona, Spain
Foraster, AC:
Inst Catala Salud Girona, Inst Assistencia Sanitaria IAS, Girona, Spain
Martinez, JR:
Hosp Univ Donostia, Inst Invest Biodonostia, San Sebastian, Spain
Padilla, FC:
Hosp Univ Canarias, Santa Cruz De Tenerife, Spain
Morlans, MP:
Hosp Univ Canarias, Santa Cruz De Tenerife, Spain
Aramburu, IG:
Hosp Univ Marques Valdecilla, Serv Neurol, Unidad Trastornos Movimiento, Santander, Spain
Ceberio, JI:
Hosp Univ Marques Valdecilla, Serv Neurol, Unidad Trastornos Movimiento, Santander, Spain
Vara, JH:
Vall DHebron Univ Campus, Neurol Dept, Barcelona, Spain
Vall DHebron Univ Campus, Neurodegenerat Dis Res Grp, Barcelona, Spain
de Fabregues-Boixar, O:
Vall DHebron Univ Campus, Neurol Dept, Barcelona, Spain
Vall DHebron Univ Campus, Neurodegenerat Dis Res Grp, Barcelona, Spain
Fonticoba, TD:
Complejo Hosp Univ Ferrol CHUF, Hosp Arquitecto Marcide, Ferrol, Spain
Pascual-Sedano, B:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Santa Creu & Sant Pau, Serv Neurol, Unidad Trastornos Movimiento, Barcelona, Spain
Univ Oberta Catalunya UOC, Fac Hlth Sci, Barcelona, Spain
Kulisevsky, J:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Santa Creu & Sant Pau, Serv Neurol, Unidad Trastornos Movimiento, Barcelona, Spain
Martinez-Martin, P:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Santos-Garcia, D:
Complejo Hosp Univ A Coruna CHUAC, La Coruna, Spain
Mir, P:
Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin, Inst Biomed Sevilla IBiS,Hosp Univ Virgen Rocio,C, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
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