Expert opinion paper on the treatment of hemophilia B with albutrepenonacog alfa
Por:
Roman, MTA, Benitez, O, Canaro, MI, Fernandez, MFL, Jaime, FLJ, Arranz, JM, Nunez, R, Lopez, MR, Aisa, CS, Jimenez-Yuste, V
Publicada:
2 sep 2021
Ahead of Print:
1 jul 2021
Resumen:
Introduction: Current guidelines recommend prophylactic treatment of hemophilia B with the missing coagulation factor IX, either with standard half-life or extended half-life products. Extended half-life products have half-lives three to six times longer than the former, allowing a reduction in the number of weekly injections and therefore, potentially impacting on treatment adherence and quality of life. Albutrepenonacog alfa is an extended half-life fusion protein of coagulation factor IX with recombinant human albumin, indicated for both on-demand and prophylactic treatment for bleeding in patients with hemophilia B of all ages. Areas covered: The authors review the clinical and pharmacokinetic characteristics of albutrepenonacog alfa, as well as the available information regarding trough levels and real-world evidence. Given the availability of other factor IX products in the market, indirect comparisons of clinical and pharmacokinetic characteristics are presented. Expert opinion: The authors exhibit their expert opinion on which patient profiles are candidates for prophylactic treatment with albutrepenonacog alfa, and on the management of patients in terms of dosing, regimens of administration and protocols for switching the treatment.
Filiaciones:
Roman, MTA:
Hosp Univ La Paz Idipaz, Hematol Dept, Haemophilia Unit, Paseo Castellana 261, Madrid 28046, Spain
Benitez, O:
Hosp Valle De Hebron, Hematol Dept, Haemophilia Unit, Barcelona, Spain
Canaro, MI:
Hosp Univ Son Espases, Hematol Serv, Palma De Mallorca, Spain
Fernandez, MFL:
Hosp Materno Infantil INIBIC CHUAC, Hematol & Hemotherapy Serv, A Couna, Spain
Jaime, FLJ:
Hosp Univ Reg Malaga, Hematol Dept, Malaga, Spain
Arranz, JM:
Hosp Santa Creu & Sant Pau, Thrombosis & Hemostasis Unit, Barcelona, Spain
Nunez, R:
Hosp Univ Virgen Rocio, Hematol Serv, Seville, Spain
Lopez, MR:
Hosp Alvaro Conqueiro, Hematol & Hemotherapy Serv, Vigo, Spain
Aisa, CS:
Hosp Univ Cruces, Hematol & Hemotherapy Serv, Hemostasis & Thrombosis Sect, Baracaldo, Spain
Jimenez-Yuste, V:
Hosp Univ La Paz IdiPaz, Hematololy Dept, Madrid, Spain
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