Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
Por:
Lleo, A, Zetterberg, H, Pegueroles, J, Karikari, TK, Carmona-Iragui, M, Ashton, NJ, Montal, V, Barroeta, I, Lantero-Rodriguez, J, Videla, L, Altuna, M, Benejam, B, Fernandez, S, Valldeneu, S, Garzon, D, Bejanin, A, Iulita, MF, Camacho, V, Medrano-Martorell, S, Belbin, O, Clarimon, J, Lehmann, S, Alcolea, D, Blesa, R, Blennow, K, Fortea, J
Publicada:
14 jul 2021
Resumen:
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 asymptomatic, 43 prodromal AD, 83 AD dementia) and 44 euploid cognitively normal controls. We measured plasma p-tau181 with a Single molecule array (Simoa) assay. We examined the diagnostic performance of p-tau181 for the detection of AD and the relationship with other fluid and imaging biomarkers. Plasma p-tau181 concentration showed an area under the curve of 0.80 [95% CI 0.73-0.87] and 0.92 [95% CI 0.89-0.95] for the discrimination between asymptomatic individuals versus those in the prodromal and dementia groups, respectively. Plasma p-tau181 correlated with atrophy and hypometabolism in temporoparietal regions. Our findings indicate that plasma p-tau181 concentration can be useful to detect AD in DS. Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology. Here, the authors investigated whether plasma ptau181 could be a potential biomarker of AD in individuals with Down syndrome (DS) and find plasma p-tau181 can detect AD in DS adults.
Filiaciones:
Lleo, A:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Zetterberg, H:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
UK Dementia Res Inst UCL, London, England
UCL Inst Neurol, Dept Neurodegenerat Dis, London, England
Pegueroles, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Karikari, TK:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Carmona-Iragui, M:
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Ashton, NJ:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden
Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Old Age Psychiat, London, England
South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr, Mental Hlth & Biomed Res Unit Dementia, London, England
Montal, V:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Barroeta, I:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Lantero-Rodriguez, J:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Videla, L:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Altuna, M:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Benejam, B:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Fernandez, S:
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Valldeneu, S:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Garzon, D:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Bejanin, A:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Iulita, MF:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Camacho, V:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Medrano-Martorell, S:
Univ Autonoma Barcelona UAB, Hosp del Mar, Barcelona, Spain
Belbin, O:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Clarimon, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Lehmann, S:
Univ Montpellier, CHU Montpellier, Inst Neurosci Montpellier, INSERM, Montpellier, France
Alcolea, D:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Blesa, R:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Blennow, K:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Fortea, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu St Pau, Dept Neurol,Memory Unit, Barcelona, Spain
Centro Invest Biomed Red Enfermedades Neurodegene, Madrid, Spain
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
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