Dopamine modulations of reward-driven music memory consolidation
Por:
Ferreri, L, Mas-Herrero, E, Cardona, G, Zatorre, RJ, Antonijoan, RM, Valle, M, Riba, J, Ripolles, P, Rodriguez-Fornells, A
Publicada:
1 oct 2021
Ahead of Print:
1 jul 2021
Resumen:
Music listening provides one of the most significant abstract rewards for humans because hearing music activates the dopaminergic mesolimbic system. Given the strong link between reward, dopamine, and memory, we aimed here to investigate the hypothesis that dopamine-dependent musical reward can drive memory improvements. Twenty-nine healthy participants of both sexes provided reward ratings of unfamiliar musical excerpts that had to be remembered following a consolidation period under three separate conditions: after the ingestion of a dopaminergic antagonist, a dopaminergic precursor, or a placebo. Linear mixed modeling of the intervention data showed that the effect of reward on memory-i.e., the greater the reward experienced while listening to the musical excerpts, the better the memory recollection performance-was modulated by both dopaminergic signaling and individual differences in reward processing. Greater pleasure was consistently associated with better memory outcomes in participants with high sensitivity to musical reward, but this effect was lost when dopaminergic signaling was disrupted in participants with average or low musical hedonia. Our work highlights the flexibility of the human dopaminergic system, which can enhance memory formation not only through explicit and/or primary reinforcers but also via abstract and aesthetic rewards such as music.
Filiaciones:
Ferreri, L:
Univ Lumiere Lyon 2, Lab Etud Mecanismes Cognitifs, Lyon, France
Mas-Herrero, E:
Bellvitge Biomed Res Inst, Cognit & Brain Plastic Unit, Barcelona 08097, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Cardona, G:
Bellvitge Biomed Res Inst, Cognit & Brain Plastic Unit, Barcelona 08097, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Zatorre, RJ:
McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada
Int Lab Brain Mus & Sound Res, Montreal, PQ, Canada
Antonijoan, RM:
Univ Autonoma Barcelona, Dept Farmacol & Terapeut, Barcelona, Spain
Valle, M:
Univ Autonoma Barcelona, Dept Farmacol & Terapeut, Barcelona, Spain
St Pau Inst Biomed Res, Pharmacokinet Pharmacodynam Modeling & Simulat, Barcelona, Spain
Riba, J:
Maastricht Univ, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands
Ripolles, P:
NYU, Dept Psychol, 6 Washington Pl, New York, NY 10003 USA
NYU, Mus & Auditory Res Lab MARL, New York, NY USA
NYU, Ctr Language Mus & Emot CLaME, Max Planck Inst, New York, NY USA
Rodriguez-Fornells, A:
Bellvitge Biomed Res Inst, Cognit & Brain Plastic Unit, Barcelona 08097, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain
|