Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies
Por:
Papotti, B, Escola-Gil, JC, Julve, J, Poti, F, Zanotti, I
Publicada:
1 ago 2021
Resumen:
Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease.
Filiaciones:
Papotti, B:
Univ Parma, Dipartimento Sci Alimenti & Farmaco, Parco Area Sci 27-A, I-43124 Parma, Italy
Escola-Gil, JC:
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona 08041, Spain
Inst Invest Biomed IIB St Pau, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid 28029, Spain
Julve, J:
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona 08041, Spain
Inst Invest Biomed IIB St Pau, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid 28029, Spain
Poti, F:
Univ Parma, Dipartimento Med & Chirurg, Unita Neurosci, Via Volturno 39-F, I-43125 Parma, Italy
Zanotti, I:
Univ Parma, Dipartimento Sci Alimenti & Farmaco, Parco Area Sci 27-A, I-43124 Parma, Italy
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