Advantages of plasmatic CXCL-10 as a prognostic and diagnostic biomarker for the risk of rejection and subclinical rejection in kidney transplantation
Por:
Millan, O, Rovira, J, Guirado, L, Espinosa, C, Budde, K, Sommerer, C, Pineiro, GJ, Diekmann, F, Brunet, M
Publicada:
1 ago 2021
Ahead of Print:
1 jul 2021
Resumen:
This study evaluate the potential of plasmatic CXCL-10 (pCXCL-10) as a pre&post transplantation prognostic and diagnostic biomarker of T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR) and subclinical rejection (SCR) risk in adult kidney recipients considering BKV and CMV infections as possible clinical confounder factors. Twenty-eight of 100 patients included experienced rejection (TCMR:14; ABMR:14); 8 SCR; 13 and 16 were diagnosed with BKV and CMV infection, respectively. Pre-transplantation pCXCL-10 was significantly increased in TCMR and ABMR and post-transplantation in TCMR, ABMR and SCR compared with nonrejectors. All CMV+ patients showed pCXCL-10 levels above the cutoff values established for rejection whereas the 80% of BKV+ patients showed pCXCL-10 concentration < 100 pg/mL. pCXCL-10 could improve pre-transplantation patient stratification and immunosuppressive treatment selection according to rejection risk; and after kidney transplantation could be a potential early prognostic biomarker for rejection. Clinical confounding factor in BKV+ and particularly in CMV+ patients must be discarded.
Filiaciones:
Millan, O:
Univ Barcelona, Hosp Clin Barcelona, Pharmacol & Toxicol Sect, CDB,IDIBAPS, C Villarroel 170, Barcelona 08036, Spain
Inst Salud Carlos III, Biomed Res Ctr Hepat & Digest Dis CIBERehd, C Sinesio Delgado 4, Madrid 28029, Spain
Rovira, J:
IDIBAPS, Lab Expt Nefrol & Trasplantament LENIT, Barcelona, Spain
Red Invest Renal REDINREN, Plaza Cortes 11, Madrid 28014, Spain
Guirado, L:
Fundacio Puigvert, Dept Nephrol, Renal Transplant Unit, Carrer Cartagena 340, Barcelona 08025, Spain
Espinosa, C:
Univ Barcelona, Hosp Clin Barcelona, Pharmacol & Toxicol Sect, CDB,IDIBAPS, C Villarroel 170, Barcelona 08036, Spain
Budde, K:
Charite Univ Med Berlin, Med Klin Schwerpunkt Nephrol, Campus Charite Mitte Luisenstr 13, D-10117 Berlin, Germany
Sommerer, C:
Heidelberg Univ, Dept Nephrol, Univ Hosp Heidelberg & Mannheim, Neuenheimer Feld 672, D-69120 Heidelberg, Germany
Pineiro, GJ:
Hosp Clin Barcelona, Dept Nephrol & Kidney Transplantat, ICNU, C Villarroel 170, Barcelona 08036, Spain
Diekmann, F:
IDIBAPS, Lab Expt Nefrol & Trasplantament LENIT, Barcelona, Spain
Red Invest Renal REDINREN, Plaza Cortes 11, Madrid 28014, Spain
Hosp Clin Barcelona, Dept Nephrol & Kidney Transplantat, ICNU, C Villarroel 170, Barcelona 08036, Spain
Brunet, M:
Univ Barcelona, Hosp Clin Barcelona, Pharmacol & Toxicol Sect, CDB,IDIBAPS, C Villarroel 170, Barcelona 08036, Spain
Inst Salud Carlos III, Biomed Res Ctr Hepat & Digest Dis CIBERehd, C Sinesio Delgado 4, Madrid 28029, Spain
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