Serum Contactin-1 in CIDP A Cross-Sectional Study
Por:
Wieske, L, Martin-Aguilar, L, Fehmi, J, Lleixa, C, Koel-Simmelink, MJA, Chatterjee, M, van Lierop, Z, Killestein, J, Verhamme, C, Querol, L, Rinaldi, S, Teunissen, CE, Eftimov, F
Publicada:
1 sep 2021
Ahead of Print:
20 jul 2021
Resumen:
Objective To investigate whether serum levels of contactin-1, a paranodal protein, correlate with paranodal injury as seen in patients with CIDP with antibodies targeting the paranodal region. Methods Serum contactin-1 levels were measured in 187 patients with CIDP and 222 healthy controls. Paranodal antibodies were investigated in all patients. Results Serum contactin-1 levels were lower in patients (N = 41) with paranodal antibodies compared with patients (N = 146) without paranodal antibodies (p < 0.01) and showed good discrimination between these groups (area under the curve 0.84; 95% CI: 0.76-0.93). Conclusions These findings suggest that serum contactin-1 levels have the potential to serve as a possible diagnostic biomarker of paranodal injury in CIDP. Classification of Evidence This study provides class II evidence that serum contactin-1 levels can discriminate between patients with CIDP with or without paranodal antibodies with a sensitivity of 71% (95% CI: 56%-85%) and a specificity of 97% (95% CI: 83%-100%).
Filiaciones:
Wieske, L:
Amsterdam UMC, Locat AMC, Amsterdam Neurosci, Dept Neurol & Neurophysiol, Amsterdam, Netherlands
Martin-Aguilar, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Neuromuscular Dis Unit, Barcelona, Spain
Fehmi, J:
John Radcliffe Hosp, Dept Clin Neuroscim, West Wing, Oxford, England
Lleixa, C:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Neuromuscular Dis Unit, Barcelona, Spain
Koel-Simmelink, MJA:
Vrije Univ, Dept Clin Chem, Amsterdam UMC, Amsterdam Neurosci,Neurochem Lab, Amsterdam, Netherlands
Chatterjee, M:
Amsterdam UMC, Locat VU Med Ctr, Amsterdam Neurosci, Dept Neurol, Amsterdam, Netherlands
van Lierop, Z:
Amsterdam UMC, Locat VU Med Ctr, Amsterdam Neurosci, Dept Neurol, Amsterdam, Netherlands
Killestein, J:
Amsterdam UMC, Locat VU Med Ctr, Amsterdam Neurosci, Dept Neurol, Amsterdam, Netherlands
Verhamme, C:
Amsterdam UMC, Locat AMC, Amsterdam Neurosci, Dept Neurol & Neurophysiol, Amsterdam, Netherlands
Querol, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Neuromuscular Dis Unit, Barcelona, Spain
Rinaldi, S:
John Radcliffe Hosp, Dept Clin Neuroscim, West Wing, Oxford, England
Teunissen, CE:
Vrije Univ, Dept Clin Chem, Amsterdam UMC, Amsterdam Neurosci,Neurochem Lab, Amsterdam, Netherlands
Eftimov, F:
Amsterdam UMC, Locat AMC, Amsterdam Neurosci, Dept Neurol & Neurophysiol, Amsterdam, Netherlands
gold, Green Published
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