Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis
Por:
Gonzalez-Blanco, L, Garcia-Portilla, MP, Gutierrez, M, Mezquida, G, Cuesta, MJ, Urbiola, E, Amoretti, S, Barcones, F, Gonzalez-Pinto, A, Pina-Camacho, L, Corripio, I, Vieta, E, Baeza, I, Toll, A, Saiz, PA, Bobes, J, Bernardo, M
Publicada:
1 oct 2021
Ahead of Print:
1 ago 2021
Resumen:
Objective: There is high prevalence of cigarette smoking in individuals with first-episode psychosis (FEP) prior to psychosis onset. The purpose of the study was to determine the impact of previous tobacco use with or without cannabis on first psychotic experiences in FEP and the impact of this use on age of onset of symptoms, including prodromes.
Methods: Retrospective analyses from the naturalistic, longitudinal, multicentre, "Phenotype-Genotype and Environmental Interaction. Application of a Predictive Model in First Psychotic Episodes (PEPs)" Study. The authors analysed sociodemographic/clinical data of 284 FEP patients and 231 matched healthy controls, and evaluated first psychotic experiences of patients using the Symptom Onset in Schizophrenia Inventory.
Results: FEP patients had significantly higher prevalence of tobacco, cannabis, and cocaine use than controls. The FEP group with tobacco use only prior to onset (N = 56) had more sleep disturbances (42.9% vs 18.8%, P = 0.003) and lower prevalence of negative symptoms, specifically social withdrawal (33.9% vs 58%, P = 0.007) than FEP with no substance use (N = 70), as well as lower prevalence of ideas of reference (80.4% vs 92.4%, P = 0.015), perceptual abnormalities (46.4% vs 67.4%, P = 0.006), hallucinations (55.4% vs 71.5%, P = 0.029), and disorganised thinking (41.1% vs 61.1%, P = 0.010) than FEP group with previous tobacco and cannabis use (N = 144). FEP patients with cannabis and tobacco use had lower age at first prodromal or psychotic symptom (mean = 23.73 years [SD = 5.09]) versus those with tobacco use only (mean = 26.21 [SD = 4.80]) (P = 0.011).
Conclusions: The use of tobacco alone was not related to earlier age of onset of a first psychotic experience, but the clinical profile of FEP patients is different depending on previous tobacco use with or without cannabis.
Filiaciones:
Gonzalez-Blanco, L:
Univ Oviedo, Biomed Res Networking Ctr Mental Hlth Network CIB, Inst Invest Sanitaria Principado Asturias ISPA, Inst Neurociencias Principado Asturias INEUROPA, Oviedo, Spain
Garcia-Portilla, MP:
Univ Oviedo, Biomed Res Networking Ctr Mental Hlth Network CIB, Inst Invest Sanitaria Principado Asturias ISPA, Inst Neurociencias Principado Asturias INEUROPA, Oviedo, Spain
Gutierrez, M:
Univ Basque Country, Araba Univ Hosp, Bioaraba Res Inst, Dept Psychiat,Dept Neurosci,CIBERSAM, Alava, Spain
Mezquida, G:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst,Barcelona Clin Schizophrenia Unit, August Pi I Sunyer Biomed Res Inst IDIBAPS,CIBERS, Barcelona, Spain
Cuesta, MJ:
Navarre Inst Hlth Res, Dept Psychiat, IdiSNA, Navarre Hosp Complex, Pamplona, Spain
Urbiola, E:
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med,IiSGM, Inst Psychiat & Mental Hlth,Dept Child & Adolesce, Madrid, Spain
Amoretti, S:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst,Barcelona Clin Schizophrenia Unit, August Pi I Sunyer Biomed Res Inst IDIBAPS,CIBERS, Barcelona, Spain
Barcones, F:
Univ Zaragoza, Hosp Univ Miguel Servet, Inst Invest Sanitaria Aragon IIS Aragon, Dept Family Med,Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, A:
Univ Basque Country, Araba Univ Hosp, Bioaraba Res Inst, Dept Psychiat,Dept Neurosci,CIBERSAM, Alava, Spain
Pina-Camacho, L:
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med,IiSGM, Inst Psychiat & Mental Hlth,Dept Child & Adolesce, Madrid, Spain
Corripio, I:
Univ Autonoma Barcelona UAB, Psychiat Dept, CIBERSAM, Inst Invest Biomed St Pau IIB SANT PAU,Hosp Sant, Barcelona, Spain
Vieta, E:
Univ Barcelona, Hosp Clin, Bipolar Disorders Unit, CIBERSAM,IDIBAPS, Barcelona, Spain
Baeza, I:
Hosp Clin Barcelona, Child & Adolescent Psychiat Serv, CIBERSAM, Barcelona, Spain
Toll, A:
CIBERSAM, Hosp Mar Med Res Inst IMIM, Barcelona, Spain
Saiz, PA:
Univ Oviedo, Biomed Res Networking Ctr Mental Hlth Network CIB, Inst Invest Sanitaria Principado Asturias ISPA, Inst Neurociencias Principado Asturias INEUROPA, Oviedo, Spain
Bobes, J:
Univ Oviedo, Biomed Res Networking Ctr Mental Hlth Network CIB, Inst Invest Sanitaria Principado Asturias ISPA, Inst Neurociencias Principado Asturias INEUROPA, Oviedo, Spain
Bernardo, M:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst,Barcelona Clin Schizophrenia Unit, August Pi I Sunyer Biomed Res Inst IDIBAPS,CIBERS, Barcelona, Spain
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