Divergent connectomic organization delineates genetic evolutionary traits in the human brain
Por:
Bueicheku, E, Gonzalez-de-Echavarri, JM, Ortiz-Teran, L, Montal, V, Uquillas, FD, De Marcos, L, Orwig, W, Kim, CM, Ortiz-Teran, E, Basaia, S, Diez, I, Sepulcre, J
Publicada:
4 oct 2021
Resumen:
The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insights are provided about the relationship between connectomics, gene expression and divergent evolutionary pathways from non-human primates to humans. Using in vivo human brain resting-state data, we detected two co-existing idiosyncratic functional systems: the segregation network, in charge of module specialization, and the integration network, responsible for information flow. Their topology was approximated to whole-brain genetic expression (Allen Human Brain Atlas) and the co-localization patterns yielded that neuron communication functionalities-linked to Neuron Projection-were overrepresented cell traits. Homologue-orthologue comparisons using dN/dS-ratios bridged the gap between neurogenetic outcomes and biological data, summarizing the known evolutionary divergent pathways within the Homo Sapiens lineage. Evidence suggests that a crosstalk between functional specialization and information flow reflects putative biological qualities of brain architecture, such as neurite cellular functions like axonal or dendrite processes, hypothesized to have been selectively conserved in the species through positive selection. These findings expand our understanding of human brain function and unveil aspects of our cognitive trajectory in relation to our simian ancestors previously left unexplored.
Filiaciones:
Bueicheku, E:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Gonzalez-de-Echavarri, JM:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Barcelona Seta Brain Res Ctr, Barcelona, Spain
Ortiz-Teran, L:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Harvard Med Sch, Brigham & Womens Hosp, Div Nucl Med & Mol Imaging, Dept Radiol, Boston, MA 02115 USA
Montal, V:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Univ Autonoma Barcelona, Biomed Res Inst Sant Pau, Hosp Santa Creu Sant Pau, Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Uquillas, FD:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA
De Marcos, L:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Univ Navarra, Sch Med, Pamplona, Spain
Orwig, W:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Kim, CM:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Ortiz-Teran, E:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Univ Rey Juan Carlos, Fac Ciencias Jurid & Sociales, Madrid, Spain
Basaia, S:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Neuroimaging Res Unit, Milan, Italy
Diez, I:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Sepulcre, J:
Harvard Med Sch, Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Dept Radiol, Boston, MA 02115 USA
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Green Published, gold
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