The Parkinson's Disease-Cognitive Rating Scale: Greek Normative Data, Clinical Utility and Cultural Considerations
Por:
Aretouli, E, Chondrogiorgi, M, Dede, O, Koutsonida, M, Lafi, C, Konstantinopoulou, E, Kulisevsky, J, Kosmidis, MH, Konitsiotis, S
Publicada:
1 ene 2022
Ahead of Print:
1 oct 2021
Resumen:
Background: The Parkinson's Disease-Cognitive Rating Scale (PD-CRS) is a comprehensive screening procedure for the evaluation of cognitive impairment in patients with Parkinson's disease (PD). Objectives: In the present study we adjusted the PD-CRS for the Greek population, developed normative data and examined its clinical utility for the assessment of cognitive functioning in Greek PD patients. In addition, the correlation of clinical characteristics with cognitive performance in PD patients was examined. Methods: Three hundred four community-dwelling healthy adults and 59 patients with PD, completed the adapted PD-CRS. Results: Healthy adults outperformed the PD patients on the total, the cortical and subcortical scores of the PD-CRS. Normative data indicated effects of both education and age on the PD-CRS. The optimal total PD-CRS cutoff score for the identification of cognitive impairment in a heterogeneous sample of PD patients, with regard to the severity of cognitive difficulties, was 79, yielding a modest sensitivity and specificity. Clinical characteristics of the patients (i.e., disease duration and functional disease burden) were related to poor performance on the PD-CRS. Conclusions: The Greek version of the PD-CRS is a useful instrument for the assessment of cognition in PD. Future prospective studies should examine its clinical utility to identify PD-cognitive subtypes (i.e., PD patients with mild cognitive impairment), to monitor cognitive changes, as well as its predictive accuracy for subsequent dementia.
Filiaciones:
Aretouli, E:
Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Central Macedon, Greece
Univ Ioannina, Sch Social Sci, Ioannina, Epirus, Greece
Chondrogiorgi, M:
Univ Ioannina, Med Sch, Dept Neurol, Ioannina, Epirus, Greece
Dede, O:
Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Central Macedon, Greece
Koutsonida, M:
Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Central Macedon, Greece
Lafi, C:
Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Central Macedon, Greece
Konstantinopoulou, E:
Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Central Macedon, Greece
Aristotle Univ Thessaloniki, Sch Med, Dept Neurol 2, Thessaloniki, Central Macedon, Greece
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona, Spain
Kosmidis, MH:
Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Central Macedon, Greece
Konitsiotis, S:
Univ Ioannina, Med Sch, Dept Neurol, Ioannina, Epirus, Greece
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