21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans
Por:
Watkins, JC, Evans, RH, Bayes, A, Booker, SA, Gibb, A, Mabb, AM, Mayer, M, Mellor, JR, Molnar, E, Niu, L, Ortega, A, Pankratov, Y, Ramos-Vicente, D, Rodriguez-Campuzano, A, Rodriguez-Moreno, A, Wang, LY, Wang, YT, Wollmuth, L, Wyllie, DJA, Zhuo, M, Frenguelli, BG
Publicada:
15 oct 2021
Ahead of Print:
1 ago 2021
Resumen:
In 1981 Jeff Watkins and Dick Evans wrote what was to become a seminal review on excitatory amino acids (EAAs) and their receptors (Watkins and Evans, 1981). Bringing together various lines of evidence dating back over several decades on: the distribution in the nervous system of putative amino acid neurotransmitters; enzymes involved in their production and metabolism; the uptake and release of amino acids; binding of EAAs to membranes; the pharmacological action of endogenous excitatory amino acids and their synthetic analogues, and notably the actions of antagonists for the excitations caused by both nerve stimulation and exogenous agonists, often using pharmacological tools developed by Jeff and his colleagues, they provided a compelling account for EAAs, especially L-glutamate, as a bona fide neurotransmitter in the nervous system. The rest, as they say, is history, but far from being consigned to history, EAA research is in rude health well into the 21st Century as this series of Special Issues of Neuropharmacology exemplifies. With EAAs and their receptors flourishing across a wide range of disciplines and clinical conditions, we enter into a dialogue with two of the most prominent and influential figures in the early days of EAA research: Jeff Watkins and Dick Evans.
Filiaciones:
Bayes, A:
Biomed Res Inst St Pau, Mol Physiol Synapse Lab, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Booker, SA:
Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain, Edinburgh, Midlothian EH8 9XD, Scotland
Gibb, A:
UCL, Res Dept Neurosci Physiol & Pharmacol, Gower St, London WC1E 6BT, England
Mabb, AM:
Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA
Mayer, M:
NINDS, NIH, Bldg 35A,Room 3D-904,35A Convent Dr, Bethesda, MD 20892 USA
Mellor, JR:
Univ Bristol, Sch Physiol Pharmacol & Neurosci, Biomed Sci Bldg,Univ Walk, Bristol BS8 1TD, Avon, England
Molnar, E:
Univ Bristol, Sch Physiol Pharmacol & Neurosci, Biomed Sci Bldg,Univ Walk, Bristol BS8 1TD, Avon, England
Niu, L:
SUNY Albany, Chem Dept, 1400 Washington Ave, Albany, NY 12222 USA
Ortega, A:
CINVESTAV, Dept Toxicol, Mexico City, DF, Mexico
Pankratov, Y:
Univ Warwick, Sch Life Sci, Coventry CV4 7AL, W Midlands, England
Ramos-Vicente, D:
Biomed Res Inst St Pau, Mol Physiol Synapse Lab, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Rodriguez-Campuzano, A:
CINVESTAV, Dept Toxicol, Mexico City, DF, Mexico
Rodriguez-Moreno, A:
Univ Pablo de Olavide, ES-41013 Seville, Spain
Wang, LY:
Univ Toronto, SickKids Res Inst, Program Neurosci & Mental Hlth, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
Univ Toronto, Dept Physiol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
Wang, YT:
Univ British Columbia, Dept Med, Vancouver, BC V6T 2B5, Canada
Wollmuth, L:
SUNY Stony Brook, Dept Neurobiol & Behav, Ctr Nervous Syst Disorders, Stony Brook, NY 11794 USA
SUNY Stony Brook, Ctr Nervous Syst Disorders, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA
Wyllie, DJA:
Univ Edinburgh, Ctr Discovery Brain Sci, Simons Initiat Developing Brain, Edinburgh, Midlothian EH8 9XD, Scotland
Zhuo, M:
Qingdao Int Acad Pk, Inst Brain Res, Qingdao 266000, Peoples R China
Frenguelli, BG:
Univ Warwick, Sch Life Sci, Coventry CV4 7AL, W Midlands, England
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