Structure and Dynamics of Large-Scale Cognitive Networks in Huntington's Disease
Por:
Aracil-Bolanos, I, Martinez-Horta, S, Gonzalez-de-Echavarri, JM, Sampedro, F, Perez-Perez, J, Horta, A, Campolongo, A, Izquierdo, C, Gomez-Anson, B, Pagonabarraga, J, Kulisevsky, J
Publicada:
1 feb 2022
Ahead of Print:
1 nov 2021
Resumen:
Background Huntington's disease is a neurodegenerative disorder characterized by clinical alterations in the motor, behavioral, and cognitive domains. However, the structure and disruptions to large-scale brain cognitive networks have not yet been established. Objective We aimed to profile changes in large-scale cognitive networks in premanifest and symptomatic patients with Huntington's disease. Methods We prospectively recruited premanifest and symptomatic Huntington's disease mutation carriers as well as healthy controls. Clinical and sociodemographic data were obtained from all participants, and resting-state functional connectivity data, using both time-averaged and dynamic functional connectivity, was acquired from whole-brain and cognitively oriented brain parcellations. Results A total of 64 gene mutation carriers and 23 healthy controls were included; 21 patients with Huntington's disease were classified as premanifest and 43 as symptomatic Huntington's disease. Compared with healthy controls, patients with Huntington's disease showed decreased network connectivity within the posterior hubs of the default-mode network and the medial prefrontal cortex, changes that correlated with cognitive (t = 2.25, P = 0.01) and disease burden scores (t = -2.42, P = 0.009). The salience network showed decreased functional connectivity between insular and supramarginal cortices and also correlated with cognitive (t = 2.11, P = 0.02) and disease burden scores (t = -2.35, P = 0.01). Dynamic analyses showed that network variability was decreased for default-central executive networks, a feature already present in premanifest mutation carriers (dynamic factor 8, P = 0.02). Conclusions Huntington's disease shows an early and widespread disruption of large-scale cognitive networks. Importantly, these changes are related to cognitive and disease burden scores, and novel dynamic functional analyses uncovered subtler network changes even in the premanifest stages.
Filiaciones:
Aracil-Bolanos, I:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
Martinez-Horta, S:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
Gonzalez-de-Echavarri, JM:
Pasqual Maragall Fdn, Barcelonasseta Brain Res Ctr, Barcelona, Spain
Hosp Mar Med Res Inst, Barcelona, Spain
Sampedro, F:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
Perez-Perez, J:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
Horta, A:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
Campolongo, A:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
Izquierdo, C:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
Gomez-Anson, B:
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
St Pau Hosp, Neuroradiol Unit, Barcelona, Spain
Pagonabarraga, J:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
Kulisevsky, J:
St Pau Hosp, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Inst Invest Biomed St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat, Madrid, Spain
hybrid, All Open Access, Hybrid Gold
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