Cognitive clusters in first-episode psychosis
Por:
Amoretti, S, Rabelo-da-Ponte, FD, Rosa, AR, Mezquida, G, Sanchez-Torres, AM, Fraguas, D, Cabrera, B, Lobo, A, Gonzalez-Pinto, A, Pina-Camacho, L, Corripio, I, Vieta, E, Torrent, C, de la Serna, E, Berge, D, Bioque, M, Garriga, M, Serra, M, Cuesta, MJ, Bernardo, M
Publicada:
1 nov 2021
Ahead of Print:
1 sep 2021
Resumen:
Impairments in a broad range of cognitive domains have been consistently reported in some individuals with first-episode psychosis (FEP). Cognitive deficits can be observed during the prodromal stage. However, the course of cognitive deficits is still unclear. The aim of this study was to identify cognitive subgroups over time and to compare their sociodemographic, clinical and functional profiles. A total of 114 patients with Schizo-phrenia Spectrum Disorders were included in the present study. We assessed subjects through psychiatric scales and eight neuropsychological tests at baseline and at two-year follow-up visit. We performed the Partition Around Medoids algorithm with all cognitive variables. Furthermore, we performed a logistic regression to identify the predictors related to the different cognitive clusters at follow-up. Two distinct subgroups were found: the first cluster characterized by cognitive impairment and a second cluster had relatively intact cognition in comparison with norms. Up to 54.7% of patients with cognitive deficits at baseline tended to improve during the first two years of treatment. Patients with intact cognition at follow-up had a higher socioeconomic status, later age of onset, lower negative symptoms and a higher cognitive reserve (CR) at baseline. CR and age of onset were the baseline variables that predicted cognitive impairment. This research allows us to obtain a better under-standing of the heterogeneous profile of psychotic disorders. Identifying the characteristics of patients who will present a cognitive impairment could improve early detection and intervention. These results suggest that enhancing CR could contribute to improving the course of the illness.
Filiaciones:
Amoretti, S:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst,Schizophrenia Unit,Dept Med, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Bar, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Hosp Univ Vall dHebron, Vall dHebron Res Inst VHIR, Grp Psychiat Mental Hlth & Addict, Psychiat Genet Unit,Dept Psychiat, Barcelona, Spain
Rabelo-da-Ponte, FD:
Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Lab Mol Psychiat, Porto Alegre, RS, Brazil
Rosa, AR:
Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Lab Mol Psychiat, Porto Alegre, RS, Brazil
Univ Fed Rio Grande do Sul UFRGS, Dept Pharmacol, Postgrad Program Psychiat & Behav Sci, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
Mezquida, G:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst,Schizophrenia Unit,Dept Med, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Bar, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Sanchez-Torres, AM:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Fraguas, D:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Complutense Madrid, Hosp Gen Univ Gregorio Maranon, Sch Med, Inst Invest Sanitaria Gregorio Maranon,Dept Child, Madrid, Spain
Cabrera, B:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst,Schizophrenia Unit,Dept Med, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Bar, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Lobo, A:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Zaragoza Univ, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, A:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Basque Country, Araba Univ Hosp, Bioaraba Res Inst, Dept Psychiat,Dept Neurociences, Vitoria, Spain
Pina-Camacho, L:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Complutense Madrid, Hosp Gen Univ Gregorio Maranon, Sch Med, Inst Invest Sanitaria Gregorio Maranon,Dept Child, Madrid, Spain
Corripio, I:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Autonoma Barcelona UAB, Psychiat Dept, Inst Invest Biomed St Pau IIB ST PAU, Hosp Santa Creu & St Pau, Barcelona, Spain
Vieta, E:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Torrent, C:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
de la Serna, E:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Clin Inst Neurosci,IDIBAPS,Dept Med, Dept Child & Adolescent Psychiat & Psychol,20175G, Barcelona, Spain
Berge, D:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Hosp del Mar Med Res Inst IMIM, Barcelona, Spain
Autonomous Univ Barcelona UAB, Barcelona, Spain
Bioque, M:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst,Schizophrenia Unit,Dept Med, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Bar, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Garriga, M:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Serra, M:
Univ Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Cuesta, MJ:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Bernardo, M:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst,Schizophrenia Unit,Dept Med, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Bar, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Barcelona, Spain
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