Mapping IPF helps identify geographic regions at higher risk for disease development and potential triggers
Por:
Shull, JG, Pay, MT, Compte, CL, Olid, M, Bermudo, G, Portillo, K, Sellares, J, Balcells, E, Vicens-Zygmunt, V, Planas-Cerezales, L, Badenes-Bonet, D, Blavia, R, Rivera-Ortega, P, Moreno, A, Sans, J, Perich, D, Barril, S, Esteban, L, Garcia-Bellmunt, L, Esplugas, J, Suarez-Cuartin, G, Bordas-Martinez, J, Castillo, D, Jolis, R, Salvador, I, Anton, SE, Villar, A, Robles-Perez, A, Cardona, MJ, Barbeta, E, Silveira, MG, Guevara, C, Dorca, J, Rosell, A, Luburich, P, Llatjos, R, Jorba, O, Molina-Molina, M
Publicada:
1 abr 2021
Ahead of Print:
1 nov 2020
Resumen:
Background and objective The relationship between IPF development and environmental factors has not been completely elucidated. Analysing geographic regions of idiopathic pulmonary fibrosis (IPF) cases could help identify those areas with higher aggregation and investigate potential triggers. We hypothesize that cross-analysing location of IPF cases and areas of consistently high air pollution concentration could lead to recognition of environmental risk factors for IPF development.
Methods This retrospective study analysed epidemiological and clinical data from 503 patients registered in the Observatory IPF.cat from January 2017 to June 2019. Incident and prevalent IPF cases from the Catalan region of Spain were graphed based on their postal address. We generated maps of the most relevant air pollutant PM2.5 from the last 10 years using data from the CALIOPE air quality forecast system and observational data.
Results In 2018, the prevalence of IPF differed across provinces; from 8.1 cases per 100 000 habitants in Barcelona to 2.0 cases per 100 000 in Girona. The ratio of IPF was higher in some areas. Mapping PM2.5 levels illustrated that certain areas with more industry, traffic and shipping maintained markedly higher PM2.5 concentrations. Most of these locations correlated with higher aggregation of IPF cases. Compared with other risk factors, PM2.5 exposure was the most frequent.
Conclusion In this retrospective study, prevalence of IPF is higher in areas of elevated PM2.5 concentration. Prospective studies with targeted pollution mapping need to be done in specific geographies to compile a broader profile of environmental factors involved in the development of pulmonary fibrosis.
Filiaciones:
Shull, JG:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Pay, MT:
Barcelona Supercomp Ctr BSC, Barcelona, Spain
Compte, CL:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Olid, M:
Barcelona Supercomp Ctr BSC, Barcelona, Spain
Bermudo, G:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Portillo, K:
Univ Hosp Trias & Pujol, ILD Multidisciplinary Unit, Badalona, Spain
Sellares, J:
Hosp Clin Barcelona, ILD Multidisciplinary Unit, IDIBAPS, Barcelona, Spain
Balcells, E:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Resp Med, Barcelona, Spain
Vicens-Zygmunt, V:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Planas-Cerezales, L:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Badenes-Bonet, D:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Resp Med, Barcelona, Spain
Pompeu Fabra Univ UPF, Sch Hlth & Life Sci, Barcelona, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Blavia, R:
Hosp Moises Broggi, Resp Dept, San Joan Despi, Spain
Rivera-Ortega, P:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Moreno, A:
Hosp Parc Tauli, Resp Dept, Sabadell, Spain
Sans, J:
Consorci Sanitari Terrassa, Resp Dept, Terrassa, Spain
Perich, D:
Consorci Sanitari Terrassa, Resp Dept, Terrassa, Spain
Barril, S:
Hosp Arnau Vilanova, Resp Dept, Lleida, Spain
Esteban, L:
Hosp Joan 23, Resp Dept, Tarragona, Spain
Garcia-Bellmunt, L:
Hosp St Joan, Resp Dept, Reus, Spain
Esplugas, J:
Hosp Martorell, Resp Dept, Barcelones, Spain
Suarez-Cuartin, G:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Bordas-Martinez, J:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Castillo, D:
Hosp St Pau & Santa Creu, ILD Multidisciplinary Unit, Barcelona, Spain
Jolis, R:
Hosp Figueres, Resp Dept, Figueres, Spain
Salvador, I:
Hosp Tortosa, Resp Dept, Tortosa, Spain
Anton, SE:
Hosp Trueta Girona, Resp Dept, Girona, Spain
Villar, A:
Hosp Valle De Hebron, ILD Multidisciplinary Unit, Barcelona, Spain
Robles-Perez, A:
Hosp Mataro, Resp Dept, Mataro, Spain
Cardona, MJ:
Hosp Igualada, Resp Dept, Igualada, Spain
Barbeta, E:
Hosp Granollers, Resp Dept, Granollers, Spain
Silveira, MG:
Parc Sanitari St Joan de Deu, Resp Dept, St Boi, Spain
Guevara, C:
Hosp St Camil, Resp Dept, Vilanova I La Geltru, Spain
Dorca, J:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Rosell, A:
Univ Hosp Trias & Pujol, ILD Multidisciplinary Unit, Badalona, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Inst Recerca Germans Trias & Pujol IGTP, Translat Resp Res Grp, Badalona, Spain
Luburich, P:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Llatjos, R:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
Jorba, O:
Barcelona Supercomp Ctr BSC, Barcelona, Spain
Molina-Molina, M:
Bellvitge Univ Hosp, IDIBELL, ILD Multidisciplinary Unit, Lhospitalet De Llobregat, Spain
CIBER Enfermedades Resp CIBERES, Madrid, Spain
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