Mood in Parkinson's disease: From early- to late-stage disease
Por:
Santos-Garcia, D, De Deus, FT, Cores, BC, Valdes, AL, Suarez, CE, Aneiros, A, Jesus, S, Aguilar, M, Pastor, P, Planellas, L, Cosgaya, M, Garcia, CJ, Caballol, N, Legarda, I, Hernandez, VJ, Cabo, I, Lopez, ML, Gonzalez, AI, Avila, RMA, Jose, CM, Nogueira, V, Puente, V, Garcia, MJM, Borrue, C, Solano, VB, Alvarez, SM, Vela, L, Escalante, S, Cubo, E, Carrillo, PF, Martinez, CJC, Sanchez, AP, Alonso, LMG, Lopez, AN, Gaston, I, Kulisevsky, J, Blazquez, EM, Seijo, M, Ruiz, MJ, Valero, C, Kurtis, M, de Fabregues-Boixar, O, Gonzalez, AJ, Prieto, JC, Lopez, DL, McAfee, D, Mir, P
Publicada:
1 may 2021
Ahead of Print:
1 nov 2020
Resumen:
Background Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration.
Methods PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined: <5 years (Group A); from 5 to <10 years (Group B); >= 10 years (Group C). Analysis with well-planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory-II [BDI-II] as dependent variable), to health-related QoL (39-item Parkinson's Disease Questionnaire [PDQ-39SI] as dependent variable) and to global QoL (European Health Interview Survey - Quality of Life Eight-Item Index [EUROHIS-QOL8] as dependent variable).
Results Six hundred and sixty-three PD patients (62.6 +/- 8.9 years old, 59.6% males) were included: Group A, 50.1% (n = 332); Group B, 33.3% (n = 221) and Group C, 16.6% (n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) (p = 0.729). However, the unique percent variance of PDQ-39SI and EUROHIS-QOL8 explained by BDI-II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS-QOL8 total score provided the highest unique contribution to mood (16.8%).
Conclusions Although depression-type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.
Filiaciones:
Santos-Garcia, D:
Complejo Hosp Univ A Coruna CHUAC, La Coruna, Spain
De Deus, FT:
Complejo Hosp Univ Ferrol CHUF, La Coruna, Spain
Cores, BC:
Complejo Hosp Univ A Coruna CHUAC, La Coruna, Spain
Valdes, AL:
Complejo Hosp Univ A Coruna CHUAC, La Coruna, Spain
Suarez, CE:
Complejo Hosp Univ Ferrol CHUF, La Coruna, Spain
Aneiros, A:
Complejo Hosp Univ Ferrol CHUF, La Coruna, Spain
Jesus, S:
Hosp Univ Virgen Rocio, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Aguilar, M:
Hosp Univ Mutua Terrassa, Barcelona, Spain
Pastor, P:
Hosp Univ Mutua Terrassa, Barcelona, Spain
Planellas, L:
Hosp Clin Barcelona, Barcelona, Spain
Cosgaya, M:
Hosp Clin Barcelona, Barcelona, Spain
Garcia, CJ:
Ctr Neurol Oms 42, Palma de Mallorca, Spain
Caballol, N:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Legarda, I:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Hernandez, VJ:
Hosp Univ Vall dHebron, Barcelona, Spain
Cabo, I:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Lopez, ML:
Hosp Univ La Princesa, Madrid, Spain
Gonzalez, AI:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Univ Marques Valdecilla, Santander, Spain
Avila, RMA:
Hosp Gen LHospitalet, Consorci Sanitari Integral, Barcelona, Spain
Jose, CM:
Hosp Univ Clin San Carlos, Madrid, Spain
Nogueira, V:
Hosp Da Costa, Lugo, Spain
Puente, V:
Hosp del Mar, Barcelona, Spain
Garcia, MJM:
Hosp Univ Virgen Macarena, Seville, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid, Spain
Solano, VB:
Inst Catala Salut, Inst Assistencia Sanitaria IAS, Girona, Spain
Alvarez, SM:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Escalante, S:
Hosp Tortosa Verge Cinta HTVC, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Carrillo, PF:
Hosp Univ Canarias, San Cristobal De La Lagu, Santa Cruz De T, Spain
Martinez, CJC:
Hosp Univ Ramon y Cajal, Madrid, Spain
Sanchez, AP:
Hosp Univ Puerta Hierro, Madrid, Spain
Alonso, LMG:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain
Lopez, AN:
Complejo Hosp Toledo, Toledo, Spain
Gaston, I:
Complejo Hosp Navarra, Pamplona, Spain
Kulisevsky, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Sant Pau, Barcelona, Spain
Blazquez, EM:
Hosp Univ Cent Asturias, Oviedo, Spain
Seijo, M:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Ruiz, MJ:
Hosp Univ Donostia, San Sebastian, Spain
Valero, C:
Hosp Arnau Vilanova, Valencia, Spain
Kurtis, M:
Hosp Ruber Int, Madrid, Spain
de Fabregues-Boixar, O:
Hosp Univ Vall dHebron, Barcelona, Spain
Gonzalez, AJ:
Hosp Univ Lucus Augusti HULA, Lugo, Spain
Prieto, JC:
Hosp Rey Juan Carlos, Madrid, Spain
Lopez, DL:
Complejo Hosp Univ Orense CHUO, Orense, Spain
McAfee, D:
Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
Mir, P:
Hosp Univ Virgen Rocio, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
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