Bone Fragility Fractures in CKD Patients
Por:
Pimentel, A, Urena-Torres, P, Bover, J, Fernandez-Martin, JL, Cohen-Solal, M
Publicada:
1 abr 2021
Ahead of Print:
1 nov 2020
Resumen:
Chronic kidney diseases (CKD) are associated with mineral and bone diseases (MBD), including pain, bone loss, and fractures. Bone fragility related to CKD includes the risk factors observed in osteoporosis in addition to those related to CKD, resulting in a higher risk of mortality related to fractures. Unawareness of such complications led to a poor management of fractures and a lack of preventive approaches. The current guidelines of the Kidney Disease Improving Global Outcomes (KDIGO) recommend the assessment of bone mineral density if results will impact treatment decision. In addition to bone density, circulating biomarkers of mineral, serum bone turnover markers, and imaging techniques are currently available to evaluate the fracture risk. The purpose of this review is to provide an overview of the epidemiology and pathogenesis of CKD-associated bone loss. The contribution of the current tools and other techniques in development are discussed. We here propose a current view of how to better predict bone fragility and the therapeutic options in CKD.
Filiaciones:
Pimentel, A:
AURA Paris Nord, St Ouen, France
Urena-Torres, P:
AURA Paris Nord, St Ouen, France
Univ Paris 05, Necker Hosp, Dept Renal Physiol, Paris, France
Bover, J:
Univ Autonoma Barcelona, IIB St Pau, Fundacio Puigvert, REDinREN,Nephrol Dept, Barcelona, Catalonia, Spain
Fernandez-Martin, JL:
Univ Oviedo, Inst Invest Sanitaria Principado Asturias ISPA, Hosp Univ Cent Asturias, REDinREN ISCIII,Bone & Mineral Res Unit, Oviedo, Asturias, Spain
Cohen-Solal, M:
INSERM U1132, Paris, France
Univ Paris, Hop Lariboisiere, Dept Rheumatol, Paris, France
Green Published, hybrid
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