Line-field confocal optical coherence tomography of basal cell carcinoma: a descriptive study
Por:
Suppa, M, Fontaine, M, Dejonckheere, G, Cinotti, E, Yelamos, O, Diet, G, Tognetti, L, Miyamoto, M, Cano, CO, Perez-Anker, J, Panagiotou, V, Trepant, AL, Monnier, J, Berot, V, Puig, S, Rubegni, P, Malvehy, J, Perrot, JL, del Marmol, V
Publicada:
1 may 2021
Ahead of Print:
1 dic 2020
Resumen:
Background Early diagnosis and subtype classification of basal cell carcinoma (BCC) are crucial to reduce morbidity and optimize treatment. Good accuracy in differentiating BCC from clinical imitators has been achieved with existing diagnostic strategies but lower performance in discriminating BCC subtypes. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to combine the technical advantages of reflectance confocal microscopy and OCT.
Objectives To identify and describe LC-OCT criteria associated with BCC and explore their association with BCC subtypes.
Methods Basal cell carcinoma were imaged with a handheld LC-OCT device before surgical excision. LC-OCT images were retrospectively evaluated by three observers for presence/absence of criteria for BCC. Multivariate logistic regression models were used to find independent predictors of BCC subtypes.
Results Eighty-nine histopathologically proven BCCs were included, of which 66 (74.2%) were pure subtypes [superficial BCC (sBCC): 19/66 (28.8%); nodular BCC (nBCC): 31/66 (47.0%); infiltrative BCC (iBCC): 16/66 (24.2%)]. Lobules, blood vessels and small bright cells within epidermis/lobules were the most frequent criteria for BCC. LC-OCT criteria independently associated with sBCC were presence of hemispheric lobules, absence of lobule separation from the epidermis, absence of stretching of the stroma; with nBCC were presence of macrolobules, absence of lobule connection to the epidermis; and with iBCC were presence of branched lobules.
Conclusions This was the first study describing the characteristics of BCC under LC-OCT examination. We proposed morphologic criteria, which could be potentially useful for diagnosis and subtype classification of BCC, as well as for its therapeutic management. Future studies are needed to assess these hypotheses.
Filiaciones:
Suppa, M:
Univ Libre Bruxelles, Dept Dermatol, Hop Erasme, Brussels, Belgium
Univ Libre Bruxelles, Inst Jules Bordet, Dept Dermatol, Brussels, Belgium
Fontaine, M:
Univ Libre Bruxelles, Dept Dermatol, Hop Erasme, Brussels, Belgium
Dejonckheere, G:
Univ Libre Bruxelles, Dept Dermatol, Hop Erasme, Brussels, Belgium
Cinotti, E:
Univ Siena, Dept Med Surg & Neurol Sci, Dermatol Unit, Siena, Italy
Yelamos, O:
Univ Barcelona, Hosp Clin Barcelona, Melanoma Unit, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dermatol Dept, Barcelona, Spain
Diet, G:
Univ Libre Bruxelles, Dept Dermatol, Hop Erasme, Brussels, Belgium
Tognetti, L:
Univ Siena, Dept Med Surg & Neurol Sci, Dermatol Unit, Siena, Italy
Miyamoto, M:
Univ Libre Bruxelles, Dept Dermatol, Hop Erasme, Brussels, Belgium
Cano, CO:
Univ Libre Bruxelles, Dept Dermatol, Hop Erasme, Brussels, Belgium
Perez-Anker, J:
Univ Barcelona, Hosp Clin Barcelona, Melanoma Unit, Barcelona, Spain
Inst Salud Carlos III, CIBER Enfermedades Raras, Barcelona, Spain
Panagiotou, V:
Univ Libre Bruxelles, Dept Pathol, Hop Erasme, Brussels, Belgium
Trepant, AL:
Univ Libre Bruxelles, Dept Pathol, Hop Erasme, Brussels, Belgium
Monnier, J:
Aix Marseille Univ, AP HM, Dept Dermatol, Marseille, France
Berot, V:
Univ Hosp St Etienne, Dept Dermatol, St Etienne, France
Puig, S:
Univ Barcelona, Hosp Clin Barcelona, Melanoma Unit, Barcelona, Spain
Inst Salud Carlos III, CIBER Enfermedades Raras, Barcelona, Spain
Rubegni, P:
Univ Siena, Dept Med Surg & Neurol Sci, Dermatol Unit, Siena, Italy
Malvehy, J:
Univ Barcelona, Hosp Clin Barcelona, Melanoma Unit, Barcelona, Spain
Inst Salud Carlos III, CIBER Enfermedades Raras, Barcelona, Spain
Perrot, JL:
Univ Hosp St Etienne, Dept Dermatol, St Etienne, France
del Marmol, V:
Univ Libre Bruxelles, Dept Dermatol, Hop Erasme, Brussels, Belgium
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