Incidence, clinical, risk factors and outcomes of Guillain-Barre in Covid-19
Por:
Fragiel, M, Miro, O, Llorens, P, Jimenez, S, Pinera, P, Burillo, G, Martin, A, Martin-Sanchez, FJ, Garcia-Lamberechts, EJ, Jacob, J, Alquezar-Arbe, A, Juarez, R, Jimenez, B, Del Rio, R, Roca, MM, Garcia, AH, Laguna, NL, Diez, MPL, Garcia, JP, Almela, AFD, Diaz, JJL, Hernandez, PE, de Lobera, NR, Porta-Etessam, J, Perez, CF, CaIvo, E, del Castillo, JG
Publicada:
1 mar 2021
Ahead of Print:
1 dic 2020
Resumen:
We diagnosed 11 Guillain-Barre syndrome (GBS) cases among 71,904 COVID patients attended at 61 Spanish emergency departments (EDs) during the 2-month pandemic peak. The relative frequency of GBS among ED patients was higher in COVID (0.15 parts per thousand) than non-COVID (0.02 parts per thousand) patients (odds ratio [OR] = 6.30, 95% confidence interval [CI] = 3.18-12.5), as was the standardized incidence (9.44 and 0.69 cases/100,000 inhabitant-years, respectively, OR = 13.5, 95% CI = 9.87-18.4). Regarding clinical characteristics, olfactory-gustatory disorders were more frequent in COVID-GBS than non-COVID-GBS (OR = 27.59, 95% CI = 1.296-587) and COVID-non-GBS (OR = 7.875, 95% CI = 1.587-39.09) patients. Although COVID-GBS patients were more frequently admitted to intensive care, mortality was not increased versus control groups. Our results suggest SARS-CoV-2 could be another viral infection causing GBS. ANN NEUROL 2020
Filiaciones:
Fragiel, M:
Univ Complutense Madrid, San Carlos Clin Hosp, Inst Invest Sanitaria San Carlos, Emergency Dept, Madrid, Spain
Miro, O:
Univ Barcelona, Clin Hosp, Inst Invest Biomed August Pi i Sunyer, Emergency Dept, Barcelona, Spain
Llorens, P:
Miguel Hernandez Univ, Alicante Gen Hosp, Emergency Dept, Alicante, Spain
Jimenez, S:
Univ Barcelona, Clin Hosp, Inst Invest Biomed August Pi i Sunyer, Emergency Dept, Barcelona, Spain
Pinera, P:
Reina Sofia Hosp, Emergency Dept, Murcia, Spain
Burillo, G:
Univ Hosp Canary Isl, Emergency Dept, Tenerife, Spain
Martin, A:
Severo Ochoa Hosp, Emergency Dept, Madrid, Spain
Martin-Sanchez, FJ:
Univ Complutense Madrid, San Carlos Clin Hosp, Inst Invest Sanitaria San Carlos, Emergency Dept, Madrid, Spain
Garcia-Lamberechts, EJ:
Univ Complutense Madrid, San Carlos Clin Hosp, Inst Invest Sanitaria San Carlos, Emergency Dept, Madrid, Spain
Jacob, J:
Bellvitge Univ Hosp, Emergency Dept, Barcelona, Spain
Alquezar-Arbe, A:
Hosp Holy Cross & St Paul, Emergency Dept, Barcelona, Spain
Juarez, R:
Our Lady Prado Hosp Talavera de la Reina, Emergency Dept, Toledo, Spain
Jimenez, B:
Vinalopo Elche Univ Hosp, Emergency Dept, Alicante, Spain
Del Rio, R:
Univ Hosp Torrevieja Alicante, Emergency Dept, Alicante, Spain
Roca, MM:
Hosp Holy Cross & St Paul, Emergency Dept, Barcelona, Spain
Garcia, AH:
Sacred Family Clin, Emergency Dept, Barcelona, Spain
Laguna, NL:
Navarra Univ Clin Madrid, Emergency Dept, Madrid, Spain
Diez, MPL:
Burgos Univ Hosp, Emergency Dept, Burgos, Spain
Garcia, JP:
Los Pedroches Valley Reg Hosp, Emergency Dept, Cordoba, Spain
Almela, AFD:
Virgin Rocio Hosp Seville, Emergency Dept, Seville, Spain
Diaz, JJL:
Lucus Augusti Lugo Univ Hosp, Emergency Dept, Lugo, Spain
Hernandez, PE:
Canary Isl Univ Hosp, Emergency Dept, Tenerife, Spain
de Lobera, NR:
San Pedro Hosp Logrono, Emergency Dept, Logrono, Spain
Porta-Etessam, J:
San Carlos Clin Hosp, Neurol Dept, Madrid, Spain
Perez, CF:
Santiago de Compostela Hosp Complex, Prevent Med Dept, La Coruna, Spain
CaIvo, E:
Univ Complutense Madrid, San Carlos Clin Hosp, Inst Invest Sanitaria San Carlos, Internal Med Dept, Madrid, Spain
del Castillo, JG:
Univ Complutense Madrid, San Carlos Clin Hosp, Inst Invest Sanitaria San Carlos, Emergency Dept, Madrid, Spain
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