Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015
Por:
Perez-Nadales, E, Alastruey-Izquierdo, A, Linares-Sicilia, MJ, Soto-Debran, JC, Abdala, E, Garcia-Rodriguez, J, Montejo, M, Munoz, P, Lleti, MS, Rezusta, A, de Pipaon, MRP, Yanez, L, Merino, E, Campos-Herrero, MI, Costa-Mateo, JM, Fortun, J, Garcia-Lozano, T, Garcia-Vidal, C, Fernandez-Ruiz, M, Sanchez-Reus, F, Castro-Mendez, C, Guerrero-Lozano, I, Soler-Palacin, P, Aguado, JM, Martinez-Martinez, L, Torre-Cisneros, J, Nucci, M
Publicada:
1 ene 2021
Resumen:
Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.
Filiaciones:
Perez-Nadales, E:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba, Cordoba, Spain
Alastruey-Izquierdo, A:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain
Linares-Sicilia, MJ:
Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba, Cordoba, Spain
Soto-Debran, JC:
Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain
Abdala, E:
Univ Sao Paulo, Hosp Clin, Sao Paulo, Brazil
Garcia-Rodriguez, J:
Hosp Univ La Paz, Madrid, Spain
Montejo, M:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Hosp Univ Cruces, Baracaldo, Spain
Munoz, P:
Univ Complutense Madrid, Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Hosp Gregorio Maranon, Madrid, Spain
Lleti, MS:
Hosp Univ & Politecn La Fe, Valencia, Spain
Rezusta, A:
Univ Zaragoza, Hosp Univ Miguel Servet, Inst Invest Sanitaria Aragon, Zaragoza, Spain
de Pipaon, MRP:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Hosp Univ Virgen Rocio, Seville, Spain
Yanez, L:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Hosp Univ Marques Valdecilla, Inst Invest Sanitaria Valdecilla, Santander, Spain
Merino, E:
Hosp Gen Univ Alicante, Alicante, Spain
Campos-Herrero, MI:
Hosp Univ Gran Canaria Doctor Negrin, Las Palmas Gran Canaria, Spain
Costa-Mateo, JM:
Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba, Cordoba, Spain
Fortun, J:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Hosp Ramon & Cajal, Madrid, Spain
Garcia-Lozano, T:
Fdn Inst Valenciano Oncol, Valencia, Spain
Garcia-Vidal, C:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Hosp Univ Bellvitge, Barcelona, Spain
Fernandez-Ruiz, M:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Univ Complutense, Hosp Univ 12 Octubre, Inst Invest Hosp 12 Octubre, Madrid, Spain
Sanchez-Reus, F:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Castro-Mendez, C:
Hosp Univ Virgen Valme, Seville, Spain
Guerrero-Lozano, I:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Hosp Univ Puerta Mar, Cadiz, Spain
Soler-Palacin, P:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Hosp Univ Vali Hebron, Barcelona, Spain
Aguado, JM:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Univ Complutense, Hosp Univ 12 Octubre, Inst Invest Hosp 12 Octubre, Madrid, Spain
Martinez-Martinez, L:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba, Cordoba, Spain
Torre-Cisneros, J:
Inst Salud Carlos III, Spanish Network Res Infect Dis, Madrid, Spain
Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba, Cordoba, Spain
Nucci, M:
Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil
Green Published, Green Submitted, gold
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