Reduced striato-cortical and inhibitory transcallosal connectivity in the motor circuit of Huntington's disease patients
Por:
Garcia-Gorro, C, de Diego-Balaguer, R, Martinez-Horta, S, Perez-Perez, J, Kulisevsky, J, Rodriguez-Dechicha, N, Vaquer, I, Subira, S, Calopa, M, Munoz, E, Santacruz, P, Ruiz-Idiago, J, Mareca, C, Caballol, N, Camara, E
Publicada:
1 ene 2018
Resumen:
Huntington's disease (HD) is a neurodegenerative disorder which is primarily associated with striatal degeneration. However, the alterations in connectivity of this structure in HD have been underinvestigated. In this study, we analyzed the functional and structural connectivity of the left putamen, while participants performed a finger-tapping task. Using fMRI and DW-MRI, 30 HD gene expansion carriers (HDGEC) and 29 healthy participants were scanned. Psychophysiological interaction analysis and DTI-based tractography were employed to examine functional and structural connectivity, respectively. Manifest HDGEC exhibited a reduced functional connectivity of the left putamen with the left and the right primary sensorimotor areas (SM1). Based on this result, the inhibitory functional connectivity between the left SM1 and the right SM1 was explored, appearing to be also decreased. In addition, the tract connecting these areas (motor corpus callosum), and the tract connecting the left putamen with the left SM1 appeared disrupted in HDGEC compared to controls. Significant correlations were found between measures of functional and structural connectivity of the motor corpus callosum, showing a coupling of both types of alterations in this tract. The observed reduction of functional and structural connectivity was associated with worse motor scores, which highlights the clinical relevance of these results. Hum Brain Mapp 39:54-71, 2018. (c) 2017 Wiley Periodicals, Inc.
Filiaciones:
Garcia-Gorro, C:
IDIBELL Inst Invest Biomed Bellvitge, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
de Diego-Balaguer, R:
IDIBELL Inst Invest Biomed Bellvitge, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Barcelona, Spain
ICREA Catalan Inst Res & Adv Studies, Barcelona, Spain
Martinez-Horta, S:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Movement Disorders Unit, Dept Neurol, Barcelona, Spain
Carlos III Inst, CIBERNED Ctr Networked Biomed Res Neurodegenerat, Madrid, Spain
Perez-Perez, J:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Movement Disorders Unit, Dept Neurol, Barcelona, Spain
Carlos III Inst, CIBERNED Ctr Networked Biomed Res Neurodegenerat, Madrid, Spain
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Movement Disorders Unit, Dept Neurol, Barcelona, Spain
Carlos III Inst, CIBERNED Ctr Networked Biomed Res Neurodegenerat, Madrid, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Rodriguez-Dechicha, N:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Vaquer, I:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Subira, S:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Univ Autonoma Barcelona, Dept Clin & Hlth Psychol, Barcelona, Spain
Calopa, M:
Hosp Univ Bellvitge, Movement Disorders Unit, Neurol Serv, Barcelona, Spain
Munoz, E:
Hosp Clin Barcelona, Neurol Serv, Movement Disorders Unit, Barcelona, Spain
IDIBAPS Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Univ Barcelona, Fac Med, Barcelona, Spain
Santacruz, P:
Hosp Clin Barcelona, Neurol Serv, Movement Disorders Unit, Barcelona, Spain
Ruiz-Idiago, J:
Hosp Mare Deu Merce, Barcelona, Spain
Mareca, C:
Hosp Mare Deu Merce, Barcelona, Spain
Caballol, N:
Hosp St Joan Despi Moises Broggi, Barcelona, Spain
Camara, E:
IDIBELL Inst Invest Biomed Bellvitge, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Green Published
|